Objective:To study the effects of oxycodone and fentanyl patient-controlled intravenous analgesia on pain, immune response and stress response after laparoscopic surgery.Methods:Patients undergoing laparoscopic surger...Objective:To study the effects of oxycodone and fentanyl patient-controlled intravenous analgesia on pain, immune response and stress response after laparoscopic surgery.Methods:Patients undergoing laparoscopic surgery in Xianning Central Hospital between June 2015 and February 2017 were selected and randomly divided into oxycodone group and fentanyl group who received postoperative oxycodone and fentanyl patient-controlled intravenous analgesia respectively. 3 d after surgery and 5 d after surgery, the serum contents of pain-related transmitters, immune indexes, stress-related molecules as well as peripheral blood contents of immune cells were measured.Results: 3 d after surgery and 5 d after surgery, CRP, TNF-α, IL-8, sICAM-1, YKL-40, Cor, C-P, FT3, FT4 and HO-1 contents in serum of oxycodone group were significantly lower than those of fentanyl group whereas CD3+CD4+T cell and CD3+CD8+T cell contents in peripheral blood as well as C3 and C4 contents in serum were significantly higher than those of fentanyl group.Conclusion:oxycodone patient-controlled intravenous analgesia after laparoscopic surgery is better than fentanyl and can reduce the pain degree, inhibit the stress response and improve the immune response.展开更多
In this paper,we propose a new nonmonotone trust region Barzilai-Borwein(BB for short)method for solving unconstrained optimization problems.The proposed method is given by a novel combination of a modified Metropolis...In this paper,we propose a new nonmonotone trust region Barzilai-Borwein(BB for short)method for solving unconstrained optimization problems.The proposed method is given by a novel combination of a modified Metropolis criterion,BB-stepsize and trust region method.The new method uses the reciprocal of BB-stepsize to approximate the Hessian matrix of the objective function in the trust region subproblems,and accepts some bad solutions according to the modified Metropolis criterion based on simulated annealing idea.Under some suitable assumptions,the global convergence of the new method is established.Some preliminary numerical results indicate that,the new method is more efficient compared with the existing trust region BB method.展开更多
文摘Objective:To study the effects of oxycodone and fentanyl patient-controlled intravenous analgesia on pain, immune response and stress response after laparoscopic surgery.Methods:Patients undergoing laparoscopic surgery in Xianning Central Hospital between June 2015 and February 2017 were selected and randomly divided into oxycodone group and fentanyl group who received postoperative oxycodone and fentanyl patient-controlled intravenous analgesia respectively. 3 d after surgery and 5 d after surgery, the serum contents of pain-related transmitters, immune indexes, stress-related molecules as well as peripheral blood contents of immune cells were measured.Results: 3 d after surgery and 5 d after surgery, CRP, TNF-α, IL-8, sICAM-1, YKL-40, Cor, C-P, FT3, FT4 and HO-1 contents in serum of oxycodone group were significantly lower than those of fentanyl group whereas CD3+CD4+T cell and CD3+CD8+T cell contents in peripheral blood as well as C3 and C4 contents in serum were significantly higher than those of fentanyl group.Conclusion:oxycodone patient-controlled intravenous analgesia after laparoscopic surgery is better than fentanyl and can reduce the pain degree, inhibit the stress response and improve the immune response.
基金supported by the National Natural Science Foundation of China(Nos.12071398,11671125,11571074,61977017)the Natural Science Foundation of Hunan Province(No.2020JJ4567)the Key Scientific Research Found of Hunan Education Department(No.20A097)。
文摘In this paper,we propose a new nonmonotone trust region Barzilai-Borwein(BB for short)method for solving unconstrained optimization problems.The proposed method is given by a novel combination of a modified Metropolis criterion,BB-stepsize and trust region method.The new method uses the reciprocal of BB-stepsize to approximate the Hessian matrix of the objective function in the trust region subproblems,and accepts some bad solutions according to the modified Metropolis criterion based on simulated annealing idea.Under some suitable assumptions,the global convergence of the new method is established.Some preliminary numerical results indicate that,the new method is more efficient compared with the existing trust region BB method.
