Objective: To explore the correlation between different types of osteonecrosis of the femoral head and blood lipids and coagulation indexes, in order to provide relevant references for the pathogenesis of osteonecrosi...Objective: To explore the correlation between different types of osteonecrosis of the femoral head and blood lipids and coagulation indexes, in order to provide relevant references for the pathogenesis of osteonecrosis of the femoral head. Methods: 308 cases of ONFH were divided into alcohol group (165 cases), hormone group (113 cases), trauma group (30 cases), and basic data of patients were collected. Blood lipid indicators: total cholesterol, triglycerides, high density lipoprotein cholesterol, low density lipoprotein cholesterol, apolipoprotein A, apolipoprotein B;coagulation indicators: activated partial thromboplastin time, plasma prothrombin time, fibrinogen, thrombin time indicators, using analysis of variance method for different types of osteonecrosis of the femoral head and blood lipids, coagulation indicators Search for relevance. Results: 1. Comparison of three groups of blood lipid indicators: total cholesterol and low density lipoprotein cholesterol in the alcohol group were higher than those in the trauma group (P<0.05);total cholesterol, triglycerides, and low density lipoprotein in the alcohol group The three indexes of cholesterol were higher than those of the hormone group (P<0.05). There was no significant difference in the serum lipid indexes of the hormone group and the trauma group (P>0.05). 2. Comparison of three groups of coagulation indicators: hormone The fibrinogen index of the group was higher than that of the trauma group (P<0.05). There was no significant difference in the coagulation index between the alcohol group and the trauma group (P>0.05). The coagulation index of the hormone group and the alcohol group was compared. The differences were not statistically significant (P>0.05). Conclusions: 1. Non-traumatic osteonecrosis of the femoral head (alcoholic, hormonal) patients are characterized by markedly elevated blood lipids (total cholesterol, low density lipoprotein cholesterol) and coagulation (fibrinogen) indicators;2. Intravascular coagulation and lipid metabolism disorders may be the pathological basis of non-traumatic Osteonecrosis of the femoral head.展开更多
Objective To clarify the antipyretic effect of the Chinese materia medica, Violae Herba (Viola yedoensis), and its active fractions by examining the effects of V. yedoensis extracts with differing polarities on body...Objective To clarify the antipyretic effect of the Chinese materia medica, Violae Herba (Viola yedoensis), and its active fractions by examining the effects of V. yedoensis extracts with differing polarities on body temperature, total white blood cell (WBC) count, WBC differential count, and total serum complement of rabbits with lipopolysaccharide (LPS)-induced fever. Methods The rabbits were treated with water and ethanolic extracts of V. yedoensis, as well as petroleum ether, ethyl acetate, and n-butanol fractions of the ethanolic extract at low-, mid- and high- doses. The LPS was injected via the ear vein of rabbits in model and treatment groups 30 min post-gavage. Their body temperature was measured at 0.5, 1.0, 1.5, 2.0, 2.5, 3.0, 3.5, 4.0, 4.5, 5.0, 5.5, and 6.0 h after the LPS challenge to calculate the temperature changes and thermal response index. After the last temperature measurement, blood samples were collected to determine the blood cell counts and total serum complement (CHs0) level. Results Compared with the model group, body temperature was significantly lower in the low-dose ethanolic extract group, low- and mid-dose petroleum ether fraction groups, and all three ethyl acetate fraction groups. Serum CHs0 levels were lower in all treatment groups, except the ethanolic extract groups, than that in the model group, with no significant difference. V. yedoensis had no significant effect on the blood cells of febrile rabbits challenged with LPS for 6 h. Conclusion The antipyretic effects of V. yedoensis are strong, and its active fractions are the petroleum ether and ethyl acetate fractions of ethanolic extract.展开更多
We study a generalized Frenkel-Kontorova model and obtain periodic and heteroclinic mountain pass solutions.The heteroclinic mountain pass solution in the second laminations is new to the generalized Frenkel-Kontorova...We study a generalized Frenkel-Kontorova model and obtain periodic and heteroclinic mountain pass solutions.The heteroclinic mountain pass solution in the second laminations is new to the generalized Frenkel-Kontorova model.Our proof follows that of Bolotin and Rabinowitz(2005)for an Allen-Cahn equation,which is different from the heat flow method of finding the critical point of the Frenkel-Kontorova model in the literature.The proofs depend on suitable choices of functionals and working spaces.We also study the multiplicity of these mountain pass solutions.展开更多
Selecting the optimal machining parameters for impeller surface is a challenging task in the automatic manufacturing industry, due to its free-form surface and deep-crooked flow channel.Existing experimental methods r...Selecting the optimal machining parameters for impeller surface is a challenging task in the automatic manufacturing industry, due to its free-form surface and deep-crooked flow channel.Existing experimental methods require lots of machining experiments and off-line tests, which may lead to high machining cost and low efficiency. This paper proposes a novel method of machining parameters optimization for an impeller based on the on-machine measuring technique. The absolute average error and standard deviation of the measured points are used to define the grey relational grade for reconstructing the objective function, and the complex problem of multi-objective optimization is simplified into a problem of single-objective optimization. Then, by comparing the values of the defined grey relational grade in a designed orthogonal experiment, the optimal combination of the machining parameters is obtained. The experiment-solving process of the objective function corresponds to the minimization of the used errors, which is advantageous to reducing the machining error. The proposed method is efficient and low-cost, since it does not require re-clamping the workpiece for off-line tests. Its effectiveness is verified by an on-machine inspection experiment of the impeller blade.展开更多
基金State administration of traditional Chinese medicine national clinical research base of traditional Chinese medicine business construction research project(No.JDZX2015272).
文摘Objective: To explore the correlation between different types of osteonecrosis of the femoral head and blood lipids and coagulation indexes, in order to provide relevant references for the pathogenesis of osteonecrosis of the femoral head. Methods: 308 cases of ONFH were divided into alcohol group (165 cases), hormone group (113 cases), trauma group (30 cases), and basic data of patients were collected. Blood lipid indicators: total cholesterol, triglycerides, high density lipoprotein cholesterol, low density lipoprotein cholesterol, apolipoprotein A, apolipoprotein B;coagulation indicators: activated partial thromboplastin time, plasma prothrombin time, fibrinogen, thrombin time indicators, using analysis of variance method for different types of osteonecrosis of the femoral head and blood lipids, coagulation indicators Search for relevance. Results: 1. Comparison of three groups of blood lipid indicators: total cholesterol and low density lipoprotein cholesterol in the alcohol group were higher than those in the trauma group (P<0.05);total cholesterol, triglycerides, and low density lipoprotein in the alcohol group The three indexes of cholesterol were higher than those of the hormone group (P<0.05). There was no significant difference in the serum lipid indexes of the hormone group and the trauma group (P>0.05). 2. Comparison of three groups of coagulation indicators: hormone The fibrinogen index of the group was higher than that of the trauma group (P<0.05). There was no significant difference in the coagulation index between the alcohol group and the trauma group (P>0.05). The coagulation index of the hormone group and the alcohol group was compared. The differences were not statistically significant (P>0.05). Conclusions: 1. Non-traumatic osteonecrosis of the femoral head (alcoholic, hormonal) patients are characterized by markedly elevated blood lipids (total cholesterol, low density lipoprotein cholesterol) and coagulation (fibrinogen) indicators;2. Intravascular coagulation and lipid metabolism disorders may be the pathological basis of non-traumatic Osteonecrosis of the femoral head.
基金National Natural Science Foundation of China(81073025)Science and Technology and Commission of Shanghai Municipality(09DZ1970100 and 09DZ2270900)Scientific Research Foundation for Returned Overseas Chinese Scholars,Ministry of Education of China
文摘Objective To clarify the antipyretic effect of the Chinese materia medica, Violae Herba (Viola yedoensis), and its active fractions by examining the effects of V. yedoensis extracts with differing polarities on body temperature, total white blood cell (WBC) count, WBC differential count, and total serum complement of rabbits with lipopolysaccharide (LPS)-induced fever. Methods The rabbits were treated with water and ethanolic extracts of V. yedoensis, as well as petroleum ether, ethyl acetate, and n-butanol fractions of the ethanolic extract at low-, mid- and high- doses. The LPS was injected via the ear vein of rabbits in model and treatment groups 30 min post-gavage. Their body temperature was measured at 0.5, 1.0, 1.5, 2.0, 2.5, 3.0, 3.5, 4.0, 4.5, 5.0, 5.5, and 6.0 h after the LPS challenge to calculate the temperature changes and thermal response index. After the last temperature measurement, blood samples were collected to determine the blood cell counts and total serum complement (CHs0) level. Results Compared with the model group, body temperature was significantly lower in the low-dose ethanolic extract group, low- and mid-dose petroleum ether fraction groups, and all three ethyl acetate fraction groups. Serum CHs0 levels were lower in all treatment groups, except the ethanolic extract groups, than that in the model group, with no significant difference. V. yedoensis had no significant effect on the blood cells of febrile rabbits challenged with LPS for 6 h. Conclusion The antipyretic effects of V. yedoensis are strong, and its active fractions are the petroleum ether and ethyl acetate fractions of ethanolic extract.
基金supported by the Fundamental Research Funds for the Central Universities(Grant No.34000-31610274)。
文摘We study a generalized Frenkel-Kontorova model and obtain periodic and heteroclinic mountain pass solutions.The heteroclinic mountain pass solution in the second laminations is new to the generalized Frenkel-Kontorova model.Our proof follows that of Bolotin and Rabinowitz(2005)for an Allen-Cahn equation,which is different from the heat flow method of finding the critical point of the Frenkel-Kontorova model in the literature.The proofs depend on suitable choices of functionals and working spaces.We also study the multiplicity of these mountain pass solutions.
基金co-supported by the National Basic Research Program of China(No.2015CB057304)the National Natural Science Foundation of China(Nos.51535004 and91648111)
文摘Selecting the optimal machining parameters for impeller surface is a challenging task in the automatic manufacturing industry, due to its free-form surface and deep-crooked flow channel.Existing experimental methods require lots of machining experiments and off-line tests, which may lead to high machining cost and low efficiency. This paper proposes a novel method of machining parameters optimization for an impeller based on the on-machine measuring technique. The absolute average error and standard deviation of the measured points are used to define the grey relational grade for reconstructing the objective function, and the complex problem of multi-objective optimization is simplified into a problem of single-objective optimization. Then, by comparing the values of the defined grey relational grade in a designed orthogonal experiment, the optimal combination of the machining parameters is obtained. The experiment-solving process of the objective function corresponds to the minimization of the used errors, which is advantageous to reducing the machining error. The proposed method is efficient and low-cost, since it does not require re-clamping the workpiece for off-line tests. Its effectiveness is verified by an on-machine inspection experiment of the impeller blade.
基金supported by the National Basic Research Program(973)of China(No.2012CB518405)the Zhejiang Traditional Medical Science and Technology Projects(No.2015ZB023),China