This article described an unprecedented synthesis of trifluoromethylthiophosphonium salts from allyl trifluoromethyl sulfoxide and phosphines in the presence of trimethylsilyl trifluoromethanesulfonate(TMSOTf)through ...This article described an unprecedented synthesis of trifluoromethylthiophosphonium salts from allyl trifluoromethyl sulfoxide and phosphines in the presence of trimethylsilyl trifluoromethanesulfonate(TMSOTf)through Mislow-Evans-type rearrangement.The resulting trifluoromethylthiophosphonium salts were firstly isolated and fully characterized.These fluoroalkylphosphonium salts,as exemplified by trifluoromethylthio triphenylphosphonium salt(6a),exhibited unique and versatile reaction with nucleophiles and deoxygenative trifluoromethylthiolation reaction of carboxylic acids.Furthermore,the photoredox catalytic tunable radical hydrotrifluoromethylation and hydrotrifluoromethythiolation of unactivated alkenes with 6a was successfully.展开更多
A silver-mediated oxidative trifluoromethylation of easily accessibleαα-trifluoromethyl alcohols with TMSCF3 was developed to access novel CF3(OCF3)CH-containing compounds.Deprotonation of CF3(OCF3)CH-substituted ar...A silver-mediated oxidative trifluoromethylation of easily accessibleαα-trifluoromethyl alcohols with TMSCF3 was developed to access novel CF3(OCF3)CH-containing compounds.Deprotonation of CF3(OCF3)CH-substituted arenes afforded synthetically useful CF3O-substituted gem-difluoroalkenes.Furthermore,evaluation of the lipophilicities(log P)indicated that CH(OCF3)CF3 is more lipophilic than the common fluorinated motifs such as CF3,OCF3,and SCF3,thus rendering the CH(OCF3)CF3 motif appealing in drug discovery.展开更多
Introduction Trichorrhexis nodosa (TN), one of the most common hair shaft anomalies, was first identified by Samuel Wilks in 1852(1)As either a congenital or acquired hair shaft disorder, TN is characterized by fragil...Introduction Trichorrhexis nodosa (TN), one of the most common hair shaft anomalies, was first identified by Samuel Wilks in 1852(1)As either a congenital or acquired hair shaft disorder, TN is characterized by fragile and easily broken hair accompanied by frayed cortical fibers and loss of the cuticle(2)Complete fracture of the hair shaft subsequently occurs. Moreover, hair shaft fragility may increase the risk of developing TN. Congenital TN, including trichothiodystrophy[3], argininosuccinic aciduria[4], Menkes syndrome[5] and trichohepatoenteric syndrome[6], is rare in the clinical setting. Acquired TN, which is provoked by hair injury secondary to physical or chemical trauma (usually physical trauma), is often overlooked in daily life. We herein reported a case of TN in a woman with androgenetic alopecia.展开更多
基金This work was supported by the National Natural Science Foundation of China(21991121,22271298)the National Key Research and Development Program of China(2021YFF0701700).
文摘This article described an unprecedented synthesis of trifluoromethylthiophosphonium salts from allyl trifluoromethyl sulfoxide and phosphines in the presence of trimethylsilyl trifluoromethanesulfonate(TMSOTf)through Mislow-Evans-type rearrangement.The resulting trifluoromethylthiophosphonium salts were firstly isolated and fully characterized.These fluoroalkylphosphonium salts,as exemplified by trifluoromethylthio triphenylphosphonium salt(6a),exhibited unique and versatile reaction with nucleophiles and deoxygenative trifluoromethylthiolation reaction of carboxylic acids.Furthermore,the photoredox catalytic tunable radical hydrotrifluoromethylation and hydrotrifluoromethythiolation of unactivated alkenes with 6a was successfully.
基金This work was supported by the National Natural Science Foundation of China(Nos.21421002,21991211)the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB20000000)Youth Innovation Promotion Association CAS(No.2016234).
文摘A silver-mediated oxidative trifluoromethylation of easily accessibleαα-trifluoromethyl alcohols with TMSCF3 was developed to access novel CF3(OCF3)CH-containing compounds.Deprotonation of CF3(OCF3)CH-substituted arenes afforded synthetically useful CF3O-substituted gem-difluoroalkenes.Furthermore,evaluation of the lipophilicities(log P)indicated that CH(OCF3)CF3 is more lipophilic than the common fluorinated motifs such as CF3,OCF3,and SCF3,thus rendering the CH(OCF3)CF3 motif appealing in drug discovery.
文摘Introduction Trichorrhexis nodosa (TN), one of the most common hair shaft anomalies, was first identified by Samuel Wilks in 1852(1)As either a congenital or acquired hair shaft disorder, TN is characterized by fragile and easily broken hair accompanied by frayed cortical fibers and loss of the cuticle(2)Complete fracture of the hair shaft subsequently occurs. Moreover, hair shaft fragility may increase the risk of developing TN. Congenital TN, including trichothiodystrophy[3], argininosuccinic aciduria[4], Menkes syndrome[5] and trichohepatoenteric syndrome[6], is rare in the clinical setting. Acquired TN, which is provoked by hair injury secondary to physical or chemical trauma (usually physical trauma), is often overlooked in daily life. We herein reported a case of TN in a woman with androgenetic alopecia.
