Coronavirus disease 2019(COVID-19),caused by infection with the severe acute respiratory syndrome coronavirus-2(SARS-CoV-2),has escalated into a global tragedy afflicting human health,life,and social governance.Throug...Coronavirus disease 2019(COVID-19),caused by infection with the severe acute respiratory syndrome coronavirus-2(SARS-CoV-2),has escalated into a global tragedy afflicting human health,life,and social governance.Through the increasing depth of research and a better understanding of this disease,it has been ascertained that,in addition to the lungs,SARS-CoV-2 can also induce injuries to other organs including the liver.Liver injury is a common clinical manifestation of COVID-19,particularly in severe cases,and is often associated with a poorer prognosis and higher severity of COVID-19.This review focuses on the general existing information on liver injury caused by COVID-19,including risk factors and subpopulations of liver injury in COVID-19,the association between preexisting liver diseases and the severity of COVID-19,and the potential mechanisms by which SARS-CoV-2 affects the liver.This review may provide some useful information for the development of therapeutic and preventive strategies for COVID-19-associated liver injury.展开更多
基金the Key Medical Science and Technology Program of Shanxi Province,No.2020XM01Shanxi“1331”Project Quality and Efficiency Improvement Plan,No.1331KFC+1 种基金Applied Basic Research Program of Shanxi Province,No.202103021224234National Natural Science Foundation of China,No.82170523.
文摘Coronavirus disease 2019(COVID-19),caused by infection with the severe acute respiratory syndrome coronavirus-2(SARS-CoV-2),has escalated into a global tragedy afflicting human health,life,and social governance.Through the increasing depth of research and a better understanding of this disease,it has been ascertained that,in addition to the lungs,SARS-CoV-2 can also induce injuries to other organs including the liver.Liver injury is a common clinical manifestation of COVID-19,particularly in severe cases,and is often associated with a poorer prognosis and higher severity of COVID-19.This review focuses on the general existing information on liver injury caused by COVID-19,including risk factors and subpopulations of liver injury in COVID-19,the association between preexisting liver diseases and the severity of COVID-19,and the potential mechanisms by which SARS-CoV-2 affects the liver.This review may provide some useful information for the development of therapeutic and preventive strategies for COVID-19-associated liver injury.
