Asparaginase(Asp)represents a key agent in induction remission for acute lymphoblastic leukemia(ALL)and certain subtypes of non-Hodgkin lymphoma(NHL).By catalyzing the hydrolysis of extracellular asparagine,thus deple...Asparaginase(Asp)represents a key agent in induction remission for acute lymphoblastic leukemia(ALL)and certain subtypes of non-Hodgkin lymphoma(NHL).By catalyzing the hydrolysis of extracellular asparagine,thus depleting the level of plasma asparagine necessary for the growth of leukemic lymphoblasts,Asp can inhibit leukemic lymphoblast protein synthesis and lead to subsequent apoptosis with little myelosuppression.[1]This will achieve anti-leukemia efficacy,and promote the remission of leukemia.[2]A previous study showed that an Asp-containing regimen could significantly increase the event-free survival rate(71%vs.31%).[3]A previous study showed that those who completed the Asp regimen had a higher 5-year event-free survival rate(90%)than those who were unable to tolerate toxicity and quitted the treatment(73%).[4]展开更多
Objectives:To evaluate the benefits of traditional Chinese herbal medicine(TCHM)plus triple therapy(TT)in the management of Helicobacter pylori(H.pylori)-induced chronic atrophic gastritis(CAG).Methods:A comprehensive...Objectives:To evaluate the benefits of traditional Chinese herbal medicine(TCHM)plus triple therapy(TT)in the management of Helicobacter pylori(H.pylori)-induced chronic atrophic gastritis(CAG).Methods:A comprehensive access and electronic database search were carried out from inception to June 2020.Prospective randomized trials(TCHM plus TT vs.TT)were selected to assess the eradication rate of H.pylori(ER of H.pylori),clinical symptom relief rate(SRR),treatment-related adverse reactions(TRAR)and 95%confidence intervals(CI)in the meta-analysis and cumulative meta-analysis(CMA).Meta-regression analysis was used to analyze heterogeneity between studies and publication bias.Results:33 studies contained 3,226 participants were included.Compared with the TT group,TCHM plus TT group showed a significantly higher ER of H.pylori(OR=4.14,95%CI:3.21-5.35;P=0.000)and SRR(OR=4.50,95%CI:3.59-5.64).Meanwhile,the TRAR of TCHM plus TT remedy was significantly lower than TT monopoly(RR=0.43,95%CI:0.29-0.64;P=0.000).The results of the CMA,sorted by publication year,duration of treatment,and sample size,confirmed that combined treatment remedy was superior to TT monopoly in respect of ER of H.pylori and SRR.Conclusions:The present study obtained reliable and convincing evidence suggesting that TCHM plus TT remedy was efficacious and safe in treating H.pylori-induced CAG.展开更多
In recent years,an increasing number of young women have been diagnosed with cancer,including some nulliparous women.Therefore,many young patients with early-stage cancer desire to preserve fertility after cytotoxic o...In recent years,an increasing number of young women have been diagnosed with cancer,including some nulliparous women.Therefore,many young patients with early-stage cancer desire to preserve fertility after cytotoxic oncological treatments.It is important to develop a multidisciplinary approach to achieve the best outcomes for each patient.On the other hand,there has been a sharp increase in microRNAs(miRNAs)as potential biomarkers for the diagnosis,prognosis,and evaluation of treatment efficacy of several diseases.MiR-543 has been reported to affect the pathogenesis and progression of diseases via complex mechanisms.Understanding the regulatory role of miR-543 may aid comprehension of the pathogenesis and treatment of a broad range of diseases.Therefore,we provide an overview of the biogenesis,function,and role of miR-543 in various systems.These results shed light on the anticancer and endometrial protection role of miR-543 in young patients with gynecologic tumors and highlight the clinical potential of miR-543-based applications and related challenges.展开更多
基金Shanghai Natural Science Foundation(No.19ZR1432900)supported this study.
文摘Asparaginase(Asp)represents a key agent in induction remission for acute lymphoblastic leukemia(ALL)and certain subtypes of non-Hodgkin lymphoma(NHL).By catalyzing the hydrolysis of extracellular asparagine,thus depleting the level of plasma asparagine necessary for the growth of leukemic lymphoblasts,Asp can inhibit leukemic lymphoblast protein synthesis and lead to subsequent apoptosis with little myelosuppression.[1]This will achieve anti-leukemia efficacy,and promote the remission of leukemia.[2]A previous study showed that an Asp-containing regimen could significantly increase the event-free survival rate(71%vs.31%).[3]A previous study showed that those who completed the Asp regimen had a higher 5-year event-free survival rate(90%)than those who were unable to tolerate toxicity and quitted the treatment(73%).[4]
基金The National Key Research and Development Program(No.2018YFC1704500).
文摘Objectives:To evaluate the benefits of traditional Chinese herbal medicine(TCHM)plus triple therapy(TT)in the management of Helicobacter pylori(H.pylori)-induced chronic atrophic gastritis(CAG).Methods:A comprehensive access and electronic database search were carried out from inception to June 2020.Prospective randomized trials(TCHM plus TT vs.TT)were selected to assess the eradication rate of H.pylori(ER of H.pylori),clinical symptom relief rate(SRR),treatment-related adverse reactions(TRAR)and 95%confidence intervals(CI)in the meta-analysis and cumulative meta-analysis(CMA).Meta-regression analysis was used to analyze heterogeneity between studies and publication bias.Results:33 studies contained 3,226 participants were included.Compared with the TT group,TCHM plus TT group showed a significantly higher ER of H.pylori(OR=4.14,95%CI:3.21-5.35;P=0.000)and SRR(OR=4.50,95%CI:3.59-5.64).Meanwhile,the TRAR of TCHM plus TT remedy was significantly lower than TT monopoly(RR=0.43,95%CI:0.29-0.64;P=0.000).The results of the CMA,sorted by publication year,duration of treatment,and sample size,confirmed that combined treatment remedy was superior to TT monopoly in respect of ER of H.pylori and SRR.Conclusions:The present study obtained reliable and convincing evidence suggesting that TCHM plus TT remedy was efficacious and safe in treating H.pylori-induced CAG.
基金This work was supported by grants from the National Basic Research Program of China(2015CB943304)National Natural Science Foundation ofChina(81671457 and 81871143 to X.YZ,31800768 to W.T.H.).
文摘In recent years,an increasing number of young women have been diagnosed with cancer,including some nulliparous women.Therefore,many young patients with early-stage cancer desire to preserve fertility after cytotoxic oncological treatments.It is important to develop a multidisciplinary approach to achieve the best outcomes for each patient.On the other hand,there has been a sharp increase in microRNAs(miRNAs)as potential biomarkers for the diagnosis,prognosis,and evaluation of treatment efficacy of several diseases.MiR-543 has been reported to affect the pathogenesis and progression of diseases via complex mechanisms.Understanding the regulatory role of miR-543 may aid comprehension of the pathogenesis and treatment of a broad range of diseases.Therefore,we provide an overview of the biogenesis,function,and role of miR-543 in various systems.These results shed light on the anticancer and endometrial protection role of miR-543 in young patients with gynecologic tumors and highlight the clinical potential of miR-543-based applications and related challenges.
