BACKGROUND Little is known about the postoperative sleep quality of infective endocarditis patients during hospitalization and after discharge.AIM To investigate the sleep characteristics of infective endocarditis pat...BACKGROUND Little is known about the postoperative sleep quality of infective endocarditis patients during hospitalization and after discharge.AIM To investigate the sleep characteristics of infective endocarditis patients and to identify potential risk factors for disturbed sleep quality after surgery.METHODS The Pittsburgh Sleep Quality Index(PSQI)and the Epworth Sleepiness Scale were used to assess patient sleep quality.Logistic regression was used to explore the potential risk factors.RESULTS The study population(n=139)had an average age of 43.40±14.56 years,and 67.6%were men(n=94).Disturbed sleep quality was observed in 86 patients(61.9%)during hospitalization and remained in 46 patients(33.1%)at 6 mo after surgery.However,both PSQI and Epworth Sleepiness Scale scores showed significant improvements at 6 mo(P<0.001 and P=0.001,respectively).Multivariable logistic regression analysis showed that the potential risk factors were age(odds ratio=1.125,95%confidence interval:1.068-1.186)and PSQI assessed during hospitalization(odds ratio=1.759,95%confidence interval:1.436-2.155).The same analysis in patients with PSQI≥8 during hospitalization suggested that not using sleep medication(odds ratio=15.893,95%confidence interval:2.385-105.889)may be another risk factor.CONCLUSION The incidence of disturbed sleep after infective endocarditis surgery is high.However,the situation improves significantly over time.Age and early postoperative high PSQI score are risk factors for disturbed sleep quality at 6 mo after surgery.展开更多
An efficient procedure for the selective preparation of hydroxy-,carbonyl-and acetal-containing 2-pyrrolidinones has been developed through radical cyclization of 1,6-dienes initiated byα-C(sp3)-H functionalization o...An efficient procedure for the selective preparation of hydroxy-,carbonyl-and acetal-containing 2-pyrrolidinones has been developed through radical cyclization of 1,6-dienes initiated byα-C(sp3)-H functionalization of alcohols.This protocol could be conducted at catalyst-free conditions at relatively low temperature(80℃)by employing commercially available tert-butyl peroxybenzoate(TBPB)as the oxidant.展开更多
基金Supported by Science and Technology Planning Project of Guangdong Province,No.A2016057.
文摘BACKGROUND Little is known about the postoperative sleep quality of infective endocarditis patients during hospitalization and after discharge.AIM To investigate the sleep characteristics of infective endocarditis patients and to identify potential risk factors for disturbed sleep quality after surgery.METHODS The Pittsburgh Sleep Quality Index(PSQI)and the Epworth Sleepiness Scale were used to assess patient sleep quality.Logistic regression was used to explore the potential risk factors.RESULTS The study population(n=139)had an average age of 43.40±14.56 years,and 67.6%were men(n=94).Disturbed sleep quality was observed in 86 patients(61.9%)during hospitalization and remained in 46 patients(33.1%)at 6 mo after surgery.However,both PSQI and Epworth Sleepiness Scale scores showed significant improvements at 6 mo(P<0.001 and P=0.001,respectively).Multivariable logistic regression analysis showed that the potential risk factors were age(odds ratio=1.125,95%confidence interval:1.068-1.186)and PSQI assessed during hospitalization(odds ratio=1.759,95%confidence interval:1.436-2.155).The same analysis in patients with PSQI≥8 during hospitalization suggested that not using sleep medication(odds ratio=15.893,95%confidence interval:2.385-105.889)may be another risk factor.CONCLUSION The incidence of disturbed sleep after infective endocarditis surgery is high.However,the situation improves significantly over time.Age and early postoperative high PSQI score are risk factors for disturbed sleep quality at 6 mo after surgery.
基金the National Natural Science Foundation of China(No.21801142)the Natural Science Foundation of Zhejiang Province(No.LQ18B020002)+1 种基金the Ningbo Municipal Natural Science Foundation(No.2019A610021)the Hunan Provincial NaturalScience Foundation of China(No.2019JJ20008)for financial support。
文摘An efficient procedure for the selective preparation of hydroxy-,carbonyl-and acetal-containing 2-pyrrolidinones has been developed through radical cyclization of 1,6-dienes initiated byα-C(sp3)-H functionalization of alcohols.This protocol could be conducted at catalyst-free conditions at relatively low temperature(80℃)by employing commercially available tert-butyl peroxybenzoate(TBPB)as the oxidant.
