Correction To:Dietary folate drives methionine metabolism to promote cancer development by stabilizing MAT IIA

Correction to:Signal Transduction and Targeted Therapy https://doi.org/10.1038/s41392-022-01017-8,published online 22 June 2022 In the process of collating the raw data,the authors noticed one inadvertent mistake occurred in Fig.2e that needs to be corrected in the article1.The correct data are provided as follows.The key findings of the article are not affected by the correction.The original article has been corrected.

Comparison of veracity and application of different CFD turbulence models for refrigerated transport

The objective of this study was to establish a comprehensively verified 3D CFD model of this experimental platformto simulate the airflowand heat transfer at different unsteady turbulence model(standardκ-ε,RNGκ-ε,Realizableκ-ε,standardκ-ω,SSTκ-ωand RSM),and to predict the temporal-spatial temperature and velocity variations during cooling.Good agreement between model prediction and measured data was obtained.The root-mean-square error(RMSE)were 1.049℃,1.033℃,1.039℃,1.037℃,1.014℃ and 1.064℃ for standardκ-ε,RNGκ-ε,Realizableκ-ε,standardκ-ω,SSTκ-ωand RSM,respectively.There were no significant differences in different turbulencemodels on simulating the temperature distribution,and itwas similar to solve the energy equation on different turbulencemodelswith two-equation eddy viscosity.This study also revealed that the simulation values of high Reynolds numbers turbulence model(e.g.standardκ-ε,RNGκ-ε,Realizableκ-εand RSM)were slightly lower thanmeasured values near the plane wall.After comparing the accuracy of six two-equation turbulencemodels,the SSTκ-ωmodel showsmore accurate predictions by a comparison of the experimental and simulated results.This research provided reliablemethod for better understanding and selecting CFD turbulence models to refrigerated transport of fresh fruit.

Dietary folate drives methionine metabolism to promote cancer development by stabilizing MAT IIA

Folic acid,served as dietary supplement,is closely linked to one-carbon metabolism and methionine metabolism.Previous clinical evidence indicated that folic acid supplementation displays dual effect on cancer development,promoting or suppressing tumor formation and progression.However,the underlying mechanism remains to be uncovered.Here,we report that high-folate diet significantly promotes cancer development in mice with hepatocellular carcinoma(HCC)induced by DEN/high-fat diet(HFD),simultaneously with increased expression of methionine adenosyltransferase 2A(gene name,MAT2A;protein name,MATIIα),the key enzyme in methionine metabolism,and acceleration of methionine cycle in cancer tissues.In contrast,folate-free diet reduces MATIIαexpression and impedes HFD-induced HCC development.Notably,methionine metabolism is dynamically reprogrammed with valosin-containing protein p97/p47 complex-interacting protein(VCIP135)which functions as a deubiquitylating enzyme to bind and stabilize MATIIαin response to folic acid signal.Consistently,upregulation of MATIIαexpression is positively correlated with increased VCIP135 protein level in human HCC tissues compared to adjacent tissues.Furthermore,liver-specific knockout of Mat2a remarkably abolishes the advocating effect of folic acid on HFD-induced HCC,demonstrating that the effect of high or free folate-diet on HFD-induced HCC relies on Mat2a.Moreover,folate and multiple intermediate metabolites in one-carbon metabolism are significantly decreased in vivo and in vitro upon Mat2a deletion.Together,folate promotes the integration of methionine and one-carbon metabolism,contributing to HCC development via hijacking MATIIαmetabolic pathway.This study provides insight into folate-promoted cancer development,strongly recommending the tailor-made folate supplement guideline for both sub-healthy populations and patients with cancer expressing high level of MATIIαexpression.