双转子连续混炼挤出机转子结构对聚丙烯/多壁碳纳米管复合材料性能的影响

双转子连续混炼挤出机转子结构对制备的复合材料性能有较大影响。文中运用2种不同结构的转子,通过母粒熔融共混方法制备了聚丙烯/多壁碳纳米管导电复合材料,并对其微观结构、流变学、导电性、力学性能进行了测试,研究了转子结构对复合材料性能的影响。结果表明,低转速下混沌转子的分散和分布混合能力均高于经典转子;采用混沌转子制备的复合材料性能更优;其导电渗流阈值低至0. 4%,体积电阻率低至105Ω·cm量级,拉伸强度达到26. 52 MPa,弯曲模量达到1544. 85 MPa,冲击韧性达到23. 98 k J/m2,断裂伸长率在16. 14%以上。

Integrated hydrologic modeling in the inland Heihe River Basin, Northwest China

As a typical inland river basin in arid Northwest China, having distinct hydrological characteristics and severe and repre- sentative water problems, the Heihe River Basin （HRB） has attracted considerable research interest worldwide and in 2007 became a pilot basin of the G-WADI network of UNESCO/1HR Many research programs have been conducted in the HRB since the 1980s, producing rich knowledge and data about the basin, which will be very helpful to further studies. This paper reviews research efforts related to hydrologic modeling and ongoing model integration studies performed in the HRB in re- cent years. Recently, an observation network covering the whole area and a Web-based data-sharing system have been estab- lished which can greatly improve data acquisition. This paper tabulates modeling activities in past years, including model ap- plications, model modifications and enhancements, and model coupling efforts. Also described is a preliminary modeling in- tegration tool designed to quickly build new models, which has been developed for hydrologic modeling purposes. Challeng- es and issues confronted in current studies are discussed, pointing toward key research directions in the future.

Comparative transcriptome analysis on candidate genes involved in lipid biosynthesis of developing kernels for three walnut cultivars in Xinjiang

Walnut(Juglans regia L.)is a good source of lipids and polyunsaturated fatty acids(PUFAs).In order to explore the biosynthesis molecular mechanism of oil accumulation and fatty acid(FA)synthesis in walnut,the samples at different development periods of three walnut cultivars,’Zhipi’(ZP),’Xinwu 417’(W417)and’Xinwen 81’(W81)were collected for transcriptomic analysis.The analysis of oil accumulation and FA profiles showed that the oil content in mature walnut kernel was nearly 70%,and over 90%of FAs were PUFAs.We identified 126 candidate genes including 64 genes for FA de novo synthesis,45 genes for triacylglycerol assembly,and 17 genes for oil bodies involved in lipid biosynthesis by RNA-sequencing.Ten key enzymes including ACCase,LACS6,LACS8,SAD,FAD2,FAD3,LPAAT1,DGAT2,PDAT2,and PLC encoded by 19 genes were highly associated with lipid biosynthesis.Quantitative PCR analysis further validated 9 important genes,and the results were well consistent with our transcriptomic data.Finally,5 important transcription factors including WRI1,ABI3,FUS3,PKL and VAL1 were identified,and their main regulatory genes might contain ACCase,KASII,LACS,FAD3 and LPAAT which were determined through correlation analysis of expression levels for 27 walnut samples.These findings will provide a comprehensive understanding and valuable information on the genetic engineering and molecular breeding in walnut.

Characteristics of 240 randomized controlled trials for adjusting constitution in preventive treatment of disease:A bibliometric analysis

Background:A growing number of randomized controlled trials(RCTs)have explored the significance of adjusting constitution for preventive treatment of disease in traditional Chinese medicine(TCM).In this study,we sought to comprehensively analyze the characteristics of these RCTs.Methods:All RCTs related to constitutional adjustment and preventive treatment of disease were included in the study.Literature was screened searching seven databases,including Pubmed,Web of Science,Embase,SinoMed,CNKI,Chongqing VIP,and Wangfang Database,from inception to December 2018.Data pertaining to bibliometrics,participants,and interventions were extracted and analyzed.Results:Two hundred and forty papers were published between 2007 and 2018,involving 240 RCTs with 55977 total participants.Sample size in these RCTs ranged from 30 to 7800.Among them,59 RCTs addressed disease prevention prior to onset involving 11 healthy states of participants,mainly for general health or sub-health population(40.68%)using health care and non-drug therapy.In control the development of existing disease(n Z 174),59 diseases were involved.Based on the number of RCTs and sample sizes,diseases including type 2 diabetes mellitus,primary hypertension,nonalcoholic fatty liver disease,and hyperlipoproteinemia accounted for 51.15%of the total patients studied.Drug therapy as an intervention was frequently used.In preventing recurrence after recovery(n Z 7),over 4 kinds of health status in participants were involved.Drug therapy combined with health care was mostly used.Most RCTs reported positive outcomes,with only one reporting negative findings(1/240).Conclusion:The number of RCTs of constitutional adjustment on preventive treatment of disease has gradually increased since 2012.Participants and intervention measures from the above-mentioned types of RCTs exhibit their own characteristics.Future systematic reviews or meta-analyses on constitutional adjustment for preventive treatment of disease are warranted.

Jacket Matrix Based on Modular (3, 5, 6) Lattice Triangular Expansion

A Lattice triangular expansion matrix is presented based on the classical Hadamard matrices, which is defined over the fields of finite characteristic. Also, the modular Lattice and Pentagon expansion matrices are structured from triangular 7x7 matrix, each of the expansion matrices are modular the sides of the shape p. The issue for the existence (necessary conditions) of odd and even order matrices of that kind is addressed. The modular Lattice code is highly efficient since it requires only additions, multiplications by constant modulo p. The modular 6 Lattice triangular expanded constellation is even possible efficiency to gain advantage from the channel selection and maximum likelihood (ML) decoding in the interference Lattice alignment (IA) system.

TBC1D15 deficiency protects against doxorubicin cardiotoxicity via inhibiting DNAPKcs cytosolic retention and DNA damage

Clinical application of doxorubicin(DOX)is heavily hindered by DOX cardiotoxicity.Several theories were postulated for DOX cardiotoxicity including DNA damage and DNA damage response(DDR),although the mechanism(s)involved remains to be elucidated.This study evaluated the potential role of TBC domain family member 15(TBC1D15)in DOX cardiotoxicity.Tamoxifen-induced cardiac-specific Tbcldi5 knockout(Tbcldi5^(CKO))or Tbcldi5 knockin(Tbcldi5^(CKI))male mice were challenged with a single dose of DOx prior to cardiac assessment 1 week or 4 weeks following DOX challenge.Adenoviruses encoding TBC1D15 or containing shRNA targeting Tbcld15 were used for Tbcld15 overexpression or knockdown in isolated primary mouse cardiomyocytes.Our results re-vealed that DOX evoked upregulation of TBC1D15 with compromised myocardial function and overt mortality,the effects of which were ameliorated and accentuated by Tbcldi5 deletion and Tbcld15 overexpression,respectively.DOX overtly evoked apoptotic cell death,the effect of which was alleviated and exacerbated by Tbcld15 knockout and overexpression,respectively.Meanwhile,DOX provoked mitochondrial membrane potential collapse,oxidative stress and DNA damage,the effects of which were mitigated and exacerbated by Tbcld15 knockdown and overexpression,respectively.Further scrutiny revealed that TBC1D15 fostered cytosolic accumulation of the cardinal DDR element DNA-dependent protein kinase catalytic subunit(DNA-PKcs).Liquid chromatography-tandem mass spectrometry and coimmunoprecipitation denoted an interaction between TBCID15 and DNA-PKcs at the segment 594-624 of TBC1D15.Moreover,overexpression of TBC1D15 mutant(A594-624,deletion of segment 594-624)failed to elicit accentuation of DOX-induced cytosolic retention of DNA-PKcs,DNA damage and cardiomyocyte apoptosis by TBC1D15 wild type.However,Tbcld15 deletion ameliorated DOXinduced cardiomyocyte contractile anomalies,apoptosis,mitochondrial anomalies,DNA damage and cytosolic DNA-PKcs accumulation,which were canceled off by DNA-PKcs inhibition or ATM activation.Taken together,our findings denoted a pivotal role for TBCID15 in DOX-induced DNA damage,mitochondrial injury,and apoptosis possibly through binding with DNA-PKcs and thus gate-keeping its cytosolic retention,a route to accentuation of cardiac contractile dysfunction in DOX-induced cardiotoxicity.

Low-temperature and flexible strategy to in-situ fabricate ZrSiO_(4)-based ceramic composites via doping and tuning solid-state reaction

Synthetic zircon(ZrSiO_(4))ceramics are typically fabricated at elevated temperatures(over 1500℃),which would lead to high manufacturing cost.Meanwhile,reports about preparing ZrSiO_(4)-based ceramic composites via controlling the solid-state reaction between zirconia(ZrO_(2))and silica(SiO_(2))are limited.In this work,we proposed a low-temperature strategy to flexibly design and fabricate ZrSiO_(4)-based ceramic composites via doping and tuning the solid-state reaction.Two ceramic composites and ZrSiO_(4) ceramics were in-situ prepared by reactive fast hot pressing(FHP)at approximately 1250℃ based on the proposed strategy,i.e.,a ZrSiO_(4)-SiO_(2) dual-phase composite with bicontinuous interpenetrating and hierarchical microstructures,a ZrSiO_(4)-ZrO_(2) dual-phase composite with a microstructure of ZrO_(2) submicron-and nano-particles embedded in a micron ZrSiO_(4) matrix,and ZrSiO_(4) ceramics with a small amount of residual ZrO_(2) nanoparticles.The results showed that the phase compositions,microstructure configurations,mechanical properties,and wear resistance of the materials can be flexibly regulated by the proposed strategy.Hence,ZrSiO_(4)-based ceramic composites with different properties can be easily fabricated based on different application scenarios.These findings would offer useful guidance for researchers to flexibly fabricate ZrSiO_(4)-based ceramic composites at low temperatures and tailor their microstructures and properties through doping and tuning the solid-state reaction.

Scalable fast benchmarking for individual quantum gates with local twirling

With the development of controllable quantum systems,fast and practical characterization of multi-qubit gates has become essential for building high-fidelity quantum computing devices.The usual way to fulfill this requirement via randomized benchmarking demands complicated implementation of numerous multi-qubit twirling gates.How to efficiently and reliably estimate the fidelity of a quantum process remains an open problem.This work thus proposes a character-cycle benchmarking protocol and a character-average benchmarking protocol using only local twirling gates to estimate the process fidelity of an individual multi-qubit operation.Our protocols were able to characterize a large class of quantum gates including and beyond the Clifford group via the local gauge transformation,which forms a universal gate set for quantum computing.We demonstrated numerically our protocols for a non-Clifford gate—controlled-(T X)and a Clifford gate—five-qubit quantum errorcorrecting encoding circuit.The numerical results show that our protocols can efficiently and reliably characterize the gate process fidelities.Compared with the cross-entropy benchmarking,the simulation results show that the character-average benchmarking achieves three orders of magnitude improvements in terms of sampling complexity.

二甲双胍原研制剂格华止~?与一种仿制制剂在大鼠模型中药代动力学和药效学比较（英文）

此研究旨在比较二甲双胍原研制剂格华止~?与一种仿制制剂在大鼠模型中药代动力学和药效学差异,从而评价仿制制剂的生物等效性。单次灌胃给予成年雄性Zucker大鼠180 mg/kg的格华止~?和二甲双胍仿制制剂(n=6),测定并比较两组间的药代动力学参数(AUC0–t,AUC0–∞,Cmax)和血糖水平。在药效学试验中,分别每天给予成年雄性Zucker大鼠180 mg/kg和300 mg/kg的格华止~?和二甲双胍仿制制剂六周(n=6),测定大鼠体重、空腹血糖、糖化血红蛋白和血清胰岛素水平并进行比较。数据分析使用SPSS 22.0和Prism 7软件。统计学显著性水平设定为P<0.05。在单剂量实验中,二甲双胍原研制剂组和仿制制剂组的药代动力学参数(AUC0–t, AUC0–∞,Cmax)无显著性差异(P>0.05)。然而仿制制剂组给药后2小时(P=0.03)和4小时(P=0.04)大鼠的血糖要显著高于原研制剂组。在多剂量试验中,六周时高剂量原研制剂组的大鼠的空腹血糖,HOMA-IR,体重等要显著低于高剂量仿制制剂组(P<0.05)。两组间的糖化血红蛋白和血清胰岛素水平没有显著性差异。在低剂量组中,六周时原研制剂组的空腹血糖要显著低于仿制制剂组,HOMA-IR和体重水平无明显差异。同时,组间血脂水平也无明显差异。在此研究中,二甲双胍仿制制剂和原研制剂格华止~?在大鼠模型中的药代动力学参数没有显著差异。但是,在多次给药后,格华止~?在血糖和体重控制、改善胰岛素抵抗等方面优于仿制制剂。

过表达TAX1BP1通过RNF34/MAVS/NLRP3通路抑制炎症小体保护急性心肌梗死

为探索炎症小体激活和自噬在急性心梗发病中的调控机制,进而寻找新的药物治疗靶点,本研究首次发现TAX1结合蛋白(TAX1BP1)作为一种可以抑制炎症通路的自噬受体蛋白,在急性心梗中表达水平下调.而在成年C57BL/6小鼠左室心肌内点注射过表达TAX1BP1的腺病毒后,可以减小心梗面积,改善心脏功能,抑制炎症小体活化,减轻线粒体损伤.进一步研究发现,TAX1BP1可以招募E3连接酶RNF34促进MAVS的K27位点泛素化,介导其自噬性降解,从而抑制MAVS与炎症小体NLRP3的结合,进而减轻NLRP3线粒体转位后炎症小体的激活.该研究主要在C57BL/6小鼠行前降支结扎术诱导急性心梗模型,并采用小动物超声、伊文氏蓝/TTC染色等观察心脏损伤程度,免疫共沉淀及免疫荧光实验观察蛋白互作等.在急性心梗中TAX1BP1表达显著下降,而心肌过表达TAX1BP1可能通过RNF34/MAVS通路抑制炎症小体活化,成为治疗急性心梗的一个可能的新药物靶点.

Erosion-deposition patterns and depo-center movements in branching channels at the near-estuary reach of the Yangtze River

Channel evolution and depo-center migrations in braided reaches are significantly influenced by variations in runoff.This study examines the effect of runoff variations on the erosion-deposition patterns and depocenter movements within branching channels of the near-estuary reach of the Yangtze River.We assume that variations in annual mean duration days of runoff discharges,ebb partition ratios in branching channels,and the erosional/depositional rates of entire channels and sub-reaches are representative of variations in runoff intensity,flow dynamics in branching channels,and morphological features in the channels.Our results show that the north region of Fujiangsha Waterway,the Liuhaisha branch of Rugaosha Waterway,the west branch of Tongzhousha Waterway,and the west branch of Langshansha Waterway experience deposition or reduced erosion under low runoff intensity,and erosion or reduced deposition under high runoff intensity,with the depocenters moving upstream and downstream,respectively.Other waterway branches undergo opposite trends in erosion-deposition patterns and depo-center movements as the runoff changes.These morphological changes may be associated with trends in ebb partition ratio as the runoff discharge rises and falls.By flattening the intra-annual distribution of runoff discharge,dam construction in the Yangtze Basin has altered the ebb partition ratios in waterway branches,affecting their erosion-deposition patterns and depo-center movements.Present trends are likely to continue into the future due to the succession of large cascade dams under construction along the upper Yangtze and ongoing climate change.