To the Editor:Adipose tissue occurs in at least two different entities in mammals and humans:brown adipose tissue(BAT)and white adipose tissue(WAT).BAT is characterized by a unique uncoupling protein 1(UCP1)in the mit...To the Editor:Adipose tissue occurs in at least two different entities in mammals and humans:brown adipose tissue(BAT)and white adipose tissue(WAT).BAT is characterized by a unique uncoupling protein 1(UCP1)in the mitochondria that enables the uncoupling of the respiratory chain from adenosine triphosphate synthesis.Thus,energy is dissipated as heat to reduce fat accumulation.BAT is also considered a highly heterogeneous tissue with abundant oxygen,blood supply,and iron-rich mitochondria.[1,2]Activation of BAT via exposure to a cold environment is considered to be a means of reducing triglycerides to fight obesity.[3]The alterations in cells and tissues of activated BAT include increased iron content and UCP1 expression in mitochondrial,blood perfusion,and lipid utilization.[4]Therefore,accurate identification and quantitative analysis of inactive and activated BAT are of great significance for the treatment of metabolic diseases that target BAT,such as obesity.展开更多
基金National Natural Science Foundation of China(No.81801653)
文摘To the Editor:Adipose tissue occurs in at least two different entities in mammals and humans:brown adipose tissue(BAT)and white adipose tissue(WAT).BAT is characterized by a unique uncoupling protein 1(UCP1)in the mitochondria that enables the uncoupling of the respiratory chain from adenosine triphosphate synthesis.Thus,energy is dissipated as heat to reduce fat accumulation.BAT is also considered a highly heterogeneous tissue with abundant oxygen,blood supply,and iron-rich mitochondria.[1,2]Activation of BAT via exposure to a cold environment is considered to be a means of reducing triglycerides to fight obesity.[3]The alterations in cells and tissues of activated BAT include increased iron content and UCP1 expression in mitochondrial,blood perfusion,and lipid utilization.[4]Therefore,accurate identification and quantitative analysis of inactive and activated BAT are of great significance for the treatment of metabolic diseases that target BAT,such as obesity.
