Upland crop-rice cropping systems(UCR)facilitate sustainable agricultural intensification.Accurate UCR cultivation mapping is needed to ensure food security,sustainable water management,and rural revitalization.Howeve...Upland crop-rice cropping systems(UCR)facilitate sustainable agricultural intensification.Accurate UCR cultivation mapping is needed to ensure food security,sustainable water management,and rural revitalization.However,datasets describing cropping systems are limited in spatial coverage and crop types.Mapping UCR is more challenging than crop identification and most existing approaches rely heavily on accurate phenology calendars and representative training samples,which limits its applications over large regions.We describe a novel algorithm(RRSS)for automatic mapping of upland crop-rice cropping systems using Sentinel-1 Synthetic Aperture Radar(SAR)and Sentinel-2 Multispectral Instrument(MSI)data.One indicator,the VV backscatter range,was proposed to discriminate UCR and another two indicators were designed by coupling greenness and pigment indices to further discriminate tobacco or oilseed UCR.The RRSS algorithm was applied to South China characterized by complex smallholder rice cropping systems and diverse topographic conditions.This study developed 10-m UCR maps of a major rice bowl in South China,the Xiang-Gan-Min(XGM)region.The performance of the RRSS algorithm was validated based on 5197 ground-truth reference sites,with an overall accuracy of 91.92%.There were7348 km^(2) areas of UCR,roughly one-half of them located in plains.The UCR was represented mainly by oilseed-UCR and tobacco-UCR,which contributed respectively 69%and 15%of UCR area.UCR patterns accounted for only one-tenth of rice production,which can be tripled by intensification from single rice cropping.Application to complex and fragmented subtropical regions suggested the spatiotemporal robustness of the RRSS algorithm,which could be further applied to generate 10-m UCR datasets for application at national or global scales.展开更多
Deep neural networks are now widely used in the medical image segmentation field for their performance superiority and no need of manual feature extraction.U-Net has been the baseline model since the very beginning du...Deep neural networks are now widely used in the medical image segmentation field for their performance superiority and no need of manual feature extraction.U-Net has been the baseline model since the very beginning due to a symmetricalU-structure for better feature extraction and fusing and suitable for small datasets.To enhance the segmentation performance of U-Net,cascaded U-Net proposes to put two U-Nets successively to segment targets from coarse to fine.However,the plain cascaded U-Net faces the problem of too less between connections so the contextual information learned by the former U-Net cannot be fully used by the latter one.In this article,we devise novel Inner Cascaded U-Net and Inner Cascaded U^(2)-Net as improvements to plain cascaded U-Net for medical image segmentation.The proposed Inner Cascaded U-Net adds inner nested connections between two U-Nets to share more contextual information.To further boost segmentation performance,we propose Inner Cascaded U^(2)-Net,which applies residual U-block to capture more global contextual information from different scales.The proposed models can be trained from scratch in an end-to-end fashion and have been evaluated on Multimodal Brain Tumor Segmentation Challenge(BraTS)2013 and ISBI Liver Tumor Segmentation Challenge(LiTS)dataset in comparison to related U-Net,cascaded U-Net,U-Net++,U^(2)-Net and state-of-the-art methods.Our experiments demonstrate that our proposed Inner Cascaded U-Net and Inner Cascaded U^(2)-Net achieve better segmentation performance in terms of dice similarity coefficient and hausdorff distance as well as get finer outline segmentation.展开更多
Fuji apple(Malus×domestica Borkh.)is a popular fruit cultivar and occupies an important position in the fruit market due to its excellent flavor and storage quality.Ethylene emission can induce respiration,which ...Fuji apple(Malus×domestica Borkh.)is a popular fruit cultivar and occupies an important position in the fruit market due to its excellent flavor and storage quality.Ethylene emission can induce respiration,which would reduce postharvest quality and increase storage losses.In order to maintain fruit quality and extend shelf life,apples are usually stored in a low-temperature environment after harvest to reduce the formation of ethylene.Volatile aroma components are regarded as one of the most important aspects of flavor quality and a key factor for apple quality grading and customer satisfaction.Ethylene emission and its relationship with volatile aromas during low temperature,however,have not been determined.In this study,the dynamic changes of volatile aroma compounds of Fuji apples stored at 4°C were detected and analyzed for 42 days.The variation of ethylene released from Fuji apple was studied correspondingly.The results showed that ethyl butyrate,ethyl caproate,ethyl 2-methylbutyrate and 2-methylbutyl acetate were the main aroma components of Fuji apple.The change in ethylene emission and the normalized peak area of volatile aroma compounds exhibited a similar tendency that increased significantly from the 3rd day to the peak on the 14th day and then decreased;there was a positive linear correlation between them with a correlation coefficient of 0.79(P<0.05).Therefore,ethylene release can be used as a potential indicator for evaluation of volatile aroma compounds in apples.Using ethylene emission as an indicator could reduce the difficulty and complexity of volatile aroma evaluation,which could be a new non-destructive inspection choice for apple flavor quality assessment.展开更多
Aims: To study RBL-2H3 cell degranulation phenomena induced by some TCMIs through cell morphological and ultra-structural observation, released enzyme activity and establish RBL-2H3 cell degranulation test indicated ...Aims: To study RBL-2H3 cell degranulation phenomena induced by some TCMIs through cell morphological and ultra-structural observation, released enzyme activity and establish RBL-2H3 cell degranulation test indicated by β- hexosaminidase activity as a method to evaluate TCMIs at nonclinical stage. Methods: RBL-2H3 cells were used to study the degranulation by co-culture with positive control C48/80 and some TCMIs through morphological and ultra-structure observation, β-hexosaminidase activity detection. RBL-2H3 cell degranulation test was established to detect β-hexosaminidase activity caused by 17 kinds of TCMIs and their ingredients. The cytotoxicity effect of some TCMIs on both RBL 2H3 and BRL cells was measured by CCK-8 assay. Results: Toluidine blue staining and ultra-structure of electronic microscope observation of treated RBL-2H3 cells showed degranulation morphologically. Detection of β-hexosaminidase activity in the supernatant of treated cells showed some TCMIs had elevated enzyme release rates. Further analysis of the ingredients and compound in Tanreqing Injection and Shengmai Injection showed Scutellaria baicalensis Georgi in Tanreqing Injection, Red ginseng and Fructus Schisandrae Chinensis in Shengmai Injection were responsible to the degranulation of RBL-2H3 cells. Osmotic pressures and pH influenced RBL-2H3 degranulation. High Osmotic pressure of Tanreqing Injection and low pH of chlorogenic acid at 2.5 and 5.0 mmol/L congcentration might be responsible to high β-hexosaminidase activity. Most of the TCMIs inducing degranulation had cytotoxicity effect for both RBL-2H3 and BRL cells, but some TCMIs inducing degranulation had no cytotoxicity effect. Conclusion: Some TCMIs can induce degranulation of RBL-2H3 cells;RBL-2H3 cell degranulation test can be used in non-clinical stage to detect the risk causing anaphylactoid reactions. Osmotic pressures and pH influenced RBL-2H3 degranulation, and they should be measured before testing. The mechanism of degranulation caused by some TCMIs is cytotoxic, and some are non-cytotoxic and may be through exicytosis.展开更多
Data analysis on tokamak plasmas is mainly based on various diagnostic systems,which are usually modularized and independent of each other.This leads to a large amount of data not being fully and effectively exploited...Data analysis on tokamak plasmas is mainly based on various diagnostic systems,which are usually modularized and independent of each other.This leads to a large amount of data not being fully and effectively exploited so that it is not conducive to revealing the deep physical mechanism.In this work,Bayesian probability inference with machine learning methods have been applied to the electron cyclotron emission and Thomson scattering diagnostic systems on HL-2A/2M,and the effects of integrated data analysis(IDA)on the electron temperature of HL-2A with Bayesian probability inference are demonstrated.A program is developed to infer the whole electron temperature profile with a confidence interval,and the program can be applied in online analysis.The IDA results show that the full profile of the electron temperature can be obtained and the diagnostic information is more comprehensive and abundant with IDA.The inference models for electron temperature analysis are established and the developed programs will serve as an experimental data analysis tool for HL-2A/2M in the near future.展开更多
Obeticholic acid(OCA),a farnesoid X receptor(FXR)agonist with favorable effects on fatty and glucose metabolism,has been considered the leading candidate drug for nonalcoholic steatohepatitis(NASH)treatment.However,it...Obeticholic acid(OCA),a farnesoid X receptor(FXR)agonist with favorable effects on fatty and glucose metabolism,has been considered the leading candidate drug for nonalcoholic steatohepatitis(NASH)treatment.However,its limited effectiveness in resolving liver fibrosis and lipotoxicity-induced cell death remains a major drawback.Ferroptosis,a newly recognized form of cell death characterized by uncontrolled lipid peroxidation,is involved in the progression of NASH.Nitric oxide(NO)is a versatile biological molecule that can degrade extracellular matrix.In this study,we developed a PEGylated thiolated hollow mesoporous silica nanoparticles(MSN)loaded with OCA,as well as a ferroptosis inhibitor liproxsatin-1 and a NO donor S-nitrosothiol(ONL@MSN).Biochemical analyses,histology,multiplexed flow cytometry,bulk-tissue RNA sequencing,and fecal 16S ribosomal RNA sequencing were utilized to evaluate the effects of the combined nanoparticle(ONL@MSN)in a mouse NASH model.Compared with the OCA-loaded nanoparticles(O@MSN),ONL@MSN not only protected against hepatic steatosis but also greatly ameliorated fibrosis and ferroptosis.ONL@MSN also displayed enhanced therapeutic actions on the maintenance of intrahepatic macrophages/monocytes homeostasis,inhibition of immune response/lipid peroxidation,and correction of microbiota dysbiosis.These findings present a promising synergistic nanotherapeutic strategy for the treatment of NASH by simultaneously targeting FXR,ferroptosis,and fibrosis.展开更多
EuCd_(2)As_(2)was theoretically predicted to be a minimal model of Weyl semimetals with a single pair of Weyl points in the ferromagnet state.However,the heavily p-doped Eu Cd_(2)As_(2)crystals in previous experiments...EuCd_(2)As_(2)was theoretically predicted to be a minimal model of Weyl semimetals with a single pair of Weyl points in the ferromagnet state.However,the heavily p-doped Eu Cd_(2)As_(2)crystals in previous experiments prevent direct identification of the semimetal hypothesis.Here,we present a comprehensive magneto-transport study of high-quality Eu Cd_(2)As_(2)crystals with ultralow bulk carrier density(10^(13)cm^(-3)).In contrast to the general expectation of a Weyl semimetal phase,Eu Cd_(2)As_(2)shows insulating behavior in both antiferromagnetic and ferromagnetic states as well as surface-dominated conduction from band bending.Moreover,the application of a dc bias current can dramatically modulate the resistance by over one order of magnitude,and induce a periodic resistance oscillation due to the geometric resonance.Such nonlinear transport results from the high nonequilibrium state induced by an electrical field near the band edge.Our results suggest an insulating phase in Eu Cd_(2)As_(2)and put a strong constraint on the underlying mechanism of anomalous transport properties in this system.展开更多
Interfacial magnetism in functional oxide heterostructures not only exhibits intriguing physical phenomena but also implies great potential for device applications.In these systems,interfacial structural and electroni...Interfacial magnetism in functional oxide heterostructures not only exhibits intriguing physical phenomena but also implies great potential for device applications.In these systems,interfacial structural and electronic reconstructions are essential for improving the stability and tunability of the magnetic properties.In this work,we constructed ultra-thinLa_(0.67)Ca_(0.33)MnO_(3)/SrRuO_(3)(SRO)layers into superlattices,which exhibited a robust ferromagnetic phase.The high Curie temperature(TC)reaches 291 K,more than 30 K higher than that of bulk LCMO.We found that the LCMO/SRO superlattices consisted of atomically-sharp and asymmetric heterointerfaces.Such a unique interface structure can trigger a sizable charge transfer as well as a ferroelectric-like polar distortion.These two interfacial effects cooperatively stabilized the high-T_(C)ferromagnetic phase.Our results could pave a promising approach towards effective control of interfacial magnetism and new designs of oxide-based spintronic devices.展开更多
With the increase of different sensors,applications and customers,the demand from data providers and users is for a new geospatial data service model,which supports low cost,high dexterity,and which would provide a co...With the increase of different sensors,applications and customers,the demand from data providers and users is for a new geospatial data service model,which supports low cost,high dexterity,and which would provide a comprehensive service.Based on such requirements and demands,the 21AT TripleSat constellation terminal and data delivery and management system has been developed by a Beijing based high-tech enterprise,Twenty First Century Aerospace Technology Co.,Ltd.(21AT).The company is the first commercial Earth observation satellite operator and service provider in China.This new geospatial data service model allows the user to directly access multi-source satellite data,manage the data order,and carry out automatic massive data production and delivery.The solution also implements safe and hierarchical user management,statistical data analysis,and automatic information reports.In addition,a mobile application is also available for users to easily access system functions.This new geospatial solution has already been successfully applied and installed in many customer sites in China,and is now available globally for international clients interested in fast geospatial solutions.It enables the success of customers’operational services.Besides providing TripleSat Constellation images,the multi-source data access system also allows the users to access other satellite data sources,based on customized agreement.This paper describes and discusses this new geospatial data service model.展开更多
Multiple charge ions (MCIs) are necessary for increasing the output energy of particles in accelerators. In general, MCI beams are largely produced by electron beam ion source (EBIS) [1], laser ion source (LIS) [2], o...Multiple charge ions (MCIs) are necessary for increasing the output energy of particles in accelerators. In general, MCI beams are largely produced by electron beam ion source (EBIS) [1], laser ion source (LIS) [2], or high-frequency (mostly >5 GHz) electron cyclotron resonance (ECR) ion source [3]. Among these, only ECR ion source can operate in the continuous wave (CW) mode, while EBIS and LIS only support pulses. In addition, ECR ion source with lower frequency (mostly 2.45 GHz) are required primarily for generating single charge state ions, because the corresponding ECR field (875 Gs) is not sufficiently strong for MCI generation [4].展开更多
A quartz-chamber 2.45 GHz electron cyclotron resonance ion source(ECRIS) was designed for diagnostic purposes at Peking University [Patent Number: ZL 201110026605.4]. This ion source can produce a maximum 84 m A hydro...A quartz-chamber 2.45 GHz electron cyclotron resonance ion source(ECRIS) was designed for diagnostic purposes at Peking University [Patent Number: ZL 201110026605.4]. This ion source can produce a maximum 84 m A hydrogen ion beam at 50 k V with a duty factor of 10%. The root-mean-square(RMS) emittance of this beam is less than 0.12π mm mrad. In our initial work,the electron temperature and electron density inside the plasma chamber had been measured with the line intensity ratio of noble gases. Based on these results, the atomic and molecular emission spectra of hydrogen were applied to determine the dissociation degree of hydrogen and the vibrational temperature of hydrogen molecules in the ground state, respectively. Measurements were performed at gas pressures from 4×10^(-4) to 1×10^(-3) Pa and at input peak RF power ranging from 1000 to 1800 W. The dissociation degree of hydrogen in the range of 0.5%-10% and the vibrational temperature of hydrogen molecules in the ground state in the range of 3500-8500 K were obtained. The plasma processes inside this ECRIS chamber were discussed based on these results.展开更多
基金supported by the National Natural Science Foundation of China(42171325,41771468)the National Key Research and Development Program of China(2022YFD2001101)+1 种基金the Science Bureau of Fujian Province(2023Y0042)the Finance Department and the Digital Economy Alliance of Fujian Province。
文摘Upland crop-rice cropping systems(UCR)facilitate sustainable agricultural intensification.Accurate UCR cultivation mapping is needed to ensure food security,sustainable water management,and rural revitalization.However,datasets describing cropping systems are limited in spatial coverage and crop types.Mapping UCR is more challenging than crop identification and most existing approaches rely heavily on accurate phenology calendars and representative training samples,which limits its applications over large regions.We describe a novel algorithm(RRSS)for automatic mapping of upland crop-rice cropping systems using Sentinel-1 Synthetic Aperture Radar(SAR)and Sentinel-2 Multispectral Instrument(MSI)data.One indicator,the VV backscatter range,was proposed to discriminate UCR and another two indicators were designed by coupling greenness and pigment indices to further discriminate tobacco or oilseed UCR.The RRSS algorithm was applied to South China characterized by complex smallholder rice cropping systems and diverse topographic conditions.This study developed 10-m UCR maps of a major rice bowl in South China,the Xiang-Gan-Min(XGM)region.The performance of the RRSS algorithm was validated based on 5197 ground-truth reference sites,with an overall accuracy of 91.92%.There were7348 km^(2) areas of UCR,roughly one-half of them located in plains.The UCR was represented mainly by oilseed-UCR and tobacco-UCR,which contributed respectively 69%and 15%of UCR area.UCR patterns accounted for only one-tenth of rice production,which can be tripled by intensification from single rice cropping.Application to complex and fragmented subtropical regions suggested the spatiotemporal robustness of the RRSS algorithm,which could be further applied to generate 10-m UCR datasets for application at national or global scales.
基金supported in part by the National Nature Science Foundation of China(No.62172299)in part by the Shanghai Municipal Science and Technology Major Project(No.2021SHZDZX0100)in part by the Fundamental Research Funds for the Central Universi-ties of China.
文摘Deep neural networks are now widely used in the medical image segmentation field for their performance superiority and no need of manual feature extraction.U-Net has been the baseline model since the very beginning due to a symmetricalU-structure for better feature extraction and fusing and suitable for small datasets.To enhance the segmentation performance of U-Net,cascaded U-Net proposes to put two U-Nets successively to segment targets from coarse to fine.However,the plain cascaded U-Net faces the problem of too less between connections so the contextual information learned by the former U-Net cannot be fully used by the latter one.In this article,we devise novel Inner Cascaded U-Net and Inner Cascaded U^(2)-Net as improvements to plain cascaded U-Net for medical image segmentation.The proposed Inner Cascaded U-Net adds inner nested connections between two U-Nets to share more contextual information.To further boost segmentation performance,we propose Inner Cascaded U^(2)-Net,which applies residual U-block to capture more global contextual information from different scales.The proposed models can be trained from scratch in an end-to-end fashion and have been evaluated on Multimodal Brain Tumor Segmentation Challenge(BraTS)2013 and ISBI Liver Tumor Segmentation Challenge(LiTS)dataset in comparison to related U-Net,cascaded U-Net,U-Net++,U^(2)-Net and state-of-the-art methods.Our experiments demonstrate that our proposed Inner Cascaded U-Net and Inner Cascaded U^(2)-Net achieve better segmentation performance in terms of dice similarity coefficient and hausdorff distance as well as get finer outline segmentation.
基金The authors would like to thank the financial support from Central Public-interest Scientific Institution Basal Research Fund(Grant No.Y2019XK18,Y2019PT17-02)Funding for Outstanding Talents of the Ministry of Agriculture of China and the Innovation Project of Chinese Academy of Agricultural Sciences(Grant No.CAAS-ASTIP-2016-AII-02).
文摘Fuji apple(Malus×domestica Borkh.)is a popular fruit cultivar and occupies an important position in the fruit market due to its excellent flavor and storage quality.Ethylene emission can induce respiration,which would reduce postharvest quality and increase storage losses.In order to maintain fruit quality and extend shelf life,apples are usually stored in a low-temperature environment after harvest to reduce the formation of ethylene.Volatile aroma components are regarded as one of the most important aspects of flavor quality and a key factor for apple quality grading and customer satisfaction.Ethylene emission and its relationship with volatile aromas during low temperature,however,have not been determined.In this study,the dynamic changes of volatile aroma compounds of Fuji apples stored at 4°C were detected and analyzed for 42 days.The variation of ethylene released from Fuji apple was studied correspondingly.The results showed that ethyl butyrate,ethyl caproate,ethyl 2-methylbutyrate and 2-methylbutyl acetate were the main aroma components of Fuji apple.The change in ethylene emission and the normalized peak area of volatile aroma compounds exhibited a similar tendency that increased significantly from the 3rd day to the peak on the 14th day and then decreased;there was a positive linear correlation between them with a correlation coefficient of 0.79(P<0.05).Therefore,ethylene release can be used as a potential indicator for evaluation of volatile aroma compounds in apples.Using ethylene emission as an indicator could reduce the difficulty and complexity of volatile aroma evaluation,which could be a new non-destructive inspection choice for apple flavor quality assessment.
文摘Aims: To study RBL-2H3 cell degranulation phenomena induced by some TCMIs through cell morphological and ultra-structural observation, released enzyme activity and establish RBL-2H3 cell degranulation test indicated by β- hexosaminidase activity as a method to evaluate TCMIs at nonclinical stage. Methods: RBL-2H3 cells were used to study the degranulation by co-culture with positive control C48/80 and some TCMIs through morphological and ultra-structure observation, β-hexosaminidase activity detection. RBL-2H3 cell degranulation test was established to detect β-hexosaminidase activity caused by 17 kinds of TCMIs and their ingredients. The cytotoxicity effect of some TCMIs on both RBL 2H3 and BRL cells was measured by CCK-8 assay. Results: Toluidine blue staining and ultra-structure of electronic microscope observation of treated RBL-2H3 cells showed degranulation morphologically. Detection of β-hexosaminidase activity in the supernatant of treated cells showed some TCMIs had elevated enzyme release rates. Further analysis of the ingredients and compound in Tanreqing Injection and Shengmai Injection showed Scutellaria baicalensis Georgi in Tanreqing Injection, Red ginseng and Fructus Schisandrae Chinensis in Shengmai Injection were responsible to the degranulation of RBL-2H3 cells. Osmotic pressures and pH influenced RBL-2H3 degranulation. High Osmotic pressure of Tanreqing Injection and low pH of chlorogenic acid at 2.5 and 5.0 mmol/L congcentration might be responsible to high β-hexosaminidase activity. Most of the TCMIs inducing degranulation had cytotoxicity effect for both RBL-2H3 and BRL cells, but some TCMIs inducing degranulation had no cytotoxicity effect. Conclusion: Some TCMIs can induce degranulation of RBL-2H3 cells;RBL-2H3 cell degranulation test can be used in non-clinical stage to detect the risk causing anaphylactoid reactions. Osmotic pressures and pH influenced RBL-2H3 degranulation, and they should be measured before testing. The mechanism of degranulation caused by some TCMIs is cytotoxic, and some are non-cytotoxic and may be through exicytosis.
基金supported by the National Magnetic Confinement Fusion Energy Research and Development Program of China(Nos.2019YFE03090100,2019YFE03040004)the National Science Foundation for Young Scientists of China(No.12005052)。
文摘Data analysis on tokamak plasmas is mainly based on various diagnostic systems,which are usually modularized and independent of each other.This leads to a large amount of data not being fully and effectively exploited so that it is not conducive to revealing the deep physical mechanism.In this work,Bayesian probability inference with machine learning methods have been applied to the electron cyclotron emission and Thomson scattering diagnostic systems on HL-2A/2M,and the effects of integrated data analysis(IDA)on the electron temperature of HL-2A with Bayesian probability inference are demonstrated.A program is developed to infer the whole electron temperature profile with a confidence interval,and the program can be applied in online analysis.The IDA results show that the full profile of the electron temperature can be obtained and the diagnostic information is more comprehensive and abundant with IDA.The inference models for electron temperature analysis are established and the developed programs will serve as an experimental data analysis tool for HL-2A/2M in the near future.
基金This work was supported by the grants from National Natural Science Foundation of China(82073915 and 82104530)Shanghai Natural Science Foundation(23ZR1477500,China)+1 种基金Shanghai Science and Technology Commission(21XD1424900,China)Shanghai Shuguang Program(19SG32,China).
文摘Obeticholic acid(OCA),a farnesoid X receptor(FXR)agonist with favorable effects on fatty and glucose metabolism,has been considered the leading candidate drug for nonalcoholic steatohepatitis(NASH)treatment.However,its limited effectiveness in resolving liver fibrosis and lipotoxicity-induced cell death remains a major drawback.Ferroptosis,a newly recognized form of cell death characterized by uncontrolled lipid peroxidation,is involved in the progression of NASH.Nitric oxide(NO)is a versatile biological molecule that can degrade extracellular matrix.In this study,we developed a PEGylated thiolated hollow mesoporous silica nanoparticles(MSN)loaded with OCA,as well as a ferroptosis inhibitor liproxsatin-1 and a NO donor S-nitrosothiol(ONL@MSN).Biochemical analyses,histology,multiplexed flow cytometry,bulk-tissue RNA sequencing,and fecal 16S ribosomal RNA sequencing were utilized to evaluate the effects of the combined nanoparticle(ONL@MSN)in a mouse NASH model.Compared with the OCA-loaded nanoparticles(O@MSN),ONL@MSN not only protected against hepatic steatosis but also greatly ameliorated fibrosis and ferroptosis.ONL@MSN also displayed enhanced therapeutic actions on the maintenance of intrahepatic macrophages/monocytes homeostasis,inhibition of immune response/lipid peroxidation,and correction of microbiota dysbiosis.These findings present a promising synergistic nanotherapeutic strategy for the treatment of NASH by simultaneously targeting FXR,ferroptosis,and fibrosis.
基金sponsored by the National Key R&D Program of China(Grant No.2022YFA1405700)the National Natural Science Foundation of China(Grant Nos.12174069,and 92365104)+6 种基金the Shuguang Program supported by Shanghai Education Development Foundation and Shanghai Municipal Education Commissionsupported by the Double First-Class Initiative Fund of Shanghai Tech Universitythe open project from Beijing National Laboratory for Condensed Matter Physicssupported by the National Key R&D Program of China(Grant No.2022YFA1602603)the National Natural Science Foundation of China(Grant No.12122411)supported by the National Natural Science Foundation of China(Grant No.12274090)the Natural Science Foundation of Shanghai(Grant No.22ZR1406300)。
文摘EuCd_(2)As_(2)was theoretically predicted to be a minimal model of Weyl semimetals with a single pair of Weyl points in the ferromagnet state.However,the heavily p-doped Eu Cd_(2)As_(2)crystals in previous experiments prevent direct identification of the semimetal hypothesis.Here,we present a comprehensive magneto-transport study of high-quality Eu Cd_(2)As_(2)crystals with ultralow bulk carrier density(10^(13)cm^(-3)).In contrast to the general expectation of a Weyl semimetal phase,Eu Cd_(2)As_(2)shows insulating behavior in both antiferromagnetic and ferromagnetic states as well as surface-dominated conduction from band bending.Moreover,the application of a dc bias current can dramatically modulate the resistance by over one order of magnitude,and induce a periodic resistance oscillation due to the geometric resonance.Such nonlinear transport results from the high nonequilibrium state induced by an electrical field near the band edge.Our results suggest an insulating phase in Eu Cd_(2)As_(2)and put a strong constraint on the underlying mechanism of anomalous transport properties in this system.
基金This work has supported by the National Basic Research Program of China(Nos.2016YFA0401003,2017YFA0403502,and 2020YFA0309100)the National Natural Science Foundation of China(Nos.11974326,12074365,11804342,U2032218,and 51872278)+2 种基金the Fundamental Research Funds for the Central Universities(Nos.WK2030000035 and WK2340000102)Hefei Science Center CAS.L.S.and K.H.were supported by the Austrian Science Fund(FWF)through Projects Nos.P30997 and P32044Calculations have been done on the Vienna Scientific Clusters(VSC).
文摘Interfacial magnetism in functional oxide heterostructures not only exhibits intriguing physical phenomena but also implies great potential for device applications.In these systems,interfacial structural and electronic reconstructions are essential for improving the stability and tunability of the magnetic properties.In this work,we constructed ultra-thinLa_(0.67)Ca_(0.33)MnO_(3)/SrRuO_(3)(SRO)layers into superlattices,which exhibited a robust ferromagnetic phase.The high Curie temperature(TC)reaches 291 K,more than 30 K higher than that of bulk LCMO.We found that the LCMO/SRO superlattices consisted of atomically-sharp and asymmetric heterointerfaces.Such a unique interface structure can trigger a sizable charge transfer as well as a ferroelectric-like polar distortion.These two interfacial effects cooperatively stabilized the high-T_(C)ferromagnetic phase.Our results could pave a promising approach towards effective control of interfacial magnetism and new designs of oxide-based spintronic devices.
基金supported by the project of Beijing Municipal Science and Technology Commission and Science and Technology Innovation Base of Cultivating and Developing Engineering[grant number Z161100005016069]the National High Technology Research and Development Program[grant number 2013AA12A303].
文摘With the increase of different sensors,applications and customers,the demand from data providers and users is for a new geospatial data service model,which supports low cost,high dexterity,and which would provide a comprehensive service.Based on such requirements and demands,the 21AT TripleSat constellation terminal and data delivery and management system has been developed by a Beijing based high-tech enterprise,Twenty First Century Aerospace Technology Co.,Ltd.(21AT).The company is the first commercial Earth observation satellite operator and service provider in China.This new geospatial data service model allows the user to directly access multi-source satellite data,manage the data order,and carry out automatic massive data production and delivery.The solution also implements safe and hierarchical user management,statistical data analysis,and automatic information reports.In addition,a mobile application is also available for users to easily access system functions.This new geospatial solution has already been successfully applied and installed in many customer sites in China,and is now available globally for international clients interested in fast geospatial solutions.It enables the success of customers’operational services.Besides providing TripleSat Constellation images,the multi-source data access system also allows the users to access other satellite data sources,based on customized agreement.This paper describes and discusses this new geospatial data service model.
基金supported by the National Natural Science Foundation of China (Grant No. 11575013)the National Basic Research Program of China (Grant No. 2014CB84550)
文摘Multiple charge ions (MCIs) are necessary for increasing the output energy of particles in accelerators. In general, MCI beams are largely produced by electron beam ion source (EBIS) [1], laser ion source (LIS) [2], or high-frequency (mostly >5 GHz) electron cyclotron resonance (ECR) ion source [3]. Among these, only ECR ion source can operate in the continuous wave (CW) mode, while EBIS and LIS only support pulses. In addition, ECR ion source with lower frequency (mostly 2.45 GHz) are required primarily for generating single charge state ions, because the corresponding ECR field (875 Gs) is not sufficiently strong for MCI generation [4].
基金supported by the National Natural Science Foundation of China(Grant Nos.11775007,and 11575013)The support from State Key Laboratory of Nuclear Physics and Technology,Peking University is appreciated
文摘A quartz-chamber 2.45 GHz electron cyclotron resonance ion source(ECRIS) was designed for diagnostic purposes at Peking University [Patent Number: ZL 201110026605.4]. This ion source can produce a maximum 84 m A hydrogen ion beam at 50 k V with a duty factor of 10%. The root-mean-square(RMS) emittance of this beam is less than 0.12π mm mrad. In our initial work,the electron temperature and electron density inside the plasma chamber had been measured with the line intensity ratio of noble gases. Based on these results, the atomic and molecular emission spectra of hydrogen were applied to determine the dissociation degree of hydrogen and the vibrational temperature of hydrogen molecules in the ground state, respectively. Measurements were performed at gas pressures from 4×10^(-4) to 1×10^(-3) Pa and at input peak RF power ranging from 1000 to 1800 W. The dissociation degree of hydrogen in the range of 0.5%-10% and the vibrational temperature of hydrogen molecules in the ground state in the range of 3500-8500 K were obtained. The plasma processes inside this ECRIS chamber were discussed based on these results.
