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BRAF V600E基因检测联合细针穿刺活检对甲状腺结节良恶性诊断中的价值 被引量:10
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作者 卢振启 龚文博 +1 位作者 黑虎 秦建武 《中国肿瘤临床》 CAS CSCD 北大核心 2019年第20期1036-1039,共4页
目的:探讨BRAF V600E基因检测联合超声引导下细针穿刺活检(fine needle aspiration biopsy,FNA)对甲状腺良恶性结节的临床诊断价值。方法:选取2018年1月至2018年6月首次收入郑州大学附属肿瘤医院穿刺活检并手术的121例患者共130枚甲状... 目的:探讨BRAF V600E基因检测联合超声引导下细针穿刺活检(fine needle aspiration biopsy,FNA)对甲状腺良恶性结节的临床诊断价值。方法:选取2018年1月至2018年6月首次收入郑州大学附属肿瘤医院穿刺活检并手术的121例患者共130枚甲状腺结节,对穿刺标本行细胞学诊断及洗脱液BRAF V600E突变基因检测。结果:130枚结节中术后病理诊断乳头状癌120枚,良性10枚,BRAF V600E基因突变检测联合FNA将细胞学诊断的敏感度由81.7%提升至92.5%,准确度由83.1%升至92.3%,差异有统计学意义(P<0.05)。结论:BRAF V600E基因检测联合FNA能有效提高甲状腺结节良恶性诊断的敏感度和准确度,比传统单纯细胞学诊断具有更大的参考价值。 展开更多
关键词 甲状腺结节 细针穿刺活检 BRAF基因
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Numerical simulations of seepage flow in rough single rock fractures 被引量:5
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作者 Qingang Zhang Yang Ju +2 位作者 wenbo gong Liang Zhang Huafei Sun 《Petroleum》 2015年第3期200-205,共6页
To investigate the relationship between the structural characteristics and seepage flow behavior of rough single rock fractures,a set of single fracture physical models were produced using the WeierstrasseMandelbrot f... To investigate the relationship between the structural characteristics and seepage flow behavior of rough single rock fractures,a set of single fracture physical models were produced using the WeierstrasseMandelbrot functions to test the seepage flow performance.Six single fractures,with various surface roughnesses characterized by fractal dimensions,were built using COMSOL multiphysics software.The fluid flow behavior through the rough fractures and the influences of the rough surfaces on the fluid flow behavior was then monitored.The numerical simulation indicates that there is a linear relationship between the average flow velocity over the entire flow path and the fractal dimension of the rough surface.It is shown that there is good agreement between the numerical results and the experimental data in terms of the properties a of the fluid flowing through the rough single rock fractures. 展开更多
关键词 Seepage flow Single fracture Rough surface Fractal dimension Fractured rock
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