The recent identification of homozygous WNT1 mutations in individuals with osteogenesis imperfecta type XV(OI-XV)has suggested that WNT1 is a key ligand promoting the differentiation and function of bone-forming osteo...The recent identification of homozygous WNT1 mutations in individuals with osteogenesis imperfecta type XV(OI-XV)has suggested that WNT1 is a key ligand promoting the differentiation and function of bone-forming osteoblasts.Although such aninfluence was supported by subsequent studies,a mouse model of OI-XV remained to be established.Therefore,we introduced a previously identified disease-causing mutation(G177C)into the murine Wnt1 gene.Homozygous Wnt1^(G177C/G177C)mice were viable and did not display defects in brain development,but the majority of 24-week-old Wnt1^(G177C/G177C)mice had skeletal fractures.This increased bone fragility was not fully explained by reduced bone mass but also by impaired bone matrix quality.Importantly,the homozygous presence of the G177C mutation did not interfere with the osteoanabolic influence of either parathyroid hormone injection or activating mutation of LRP5,the latter mimicking the effect of sclerostin neutralization.Finally,transcriptomic analyses revealed that short-term administration of WNT1 to osteogenic cells induced not only the expression of canonical WNT signaling targets but also the expression of genes encoding extracellular matrix modifiers.Taken together,our data demonstrate that regulating bone matrix quality is a primary function of WNT1.They further suggest that individuals with WNT1 mutations should profit from existing osteoanabolic therapies.展开更多
Based on the previous case study in promoting transformative learning of college English teachers,who participated in a three-month online training courses,the article made a further research and concluded four strate...Based on the previous case study in promoting transformative learning of college English teachers,who participated in a three-month online training courses,the article made a further research and concluded four strategies on promoting transformative learning of college English Teachers.展开更多
In order to improve the acquisition probability of satellite navigation signals, this paper proposes a novel code acquisition method based on wavelet transform filtering. Firstly, the signal vector based on the signal...In order to improve the acquisition probability of satellite navigation signals, this paper proposes a novel code acquisition method based on wavelet transform filtering. Firstly, the signal vector based on the signal passing through a set of partial matched filters(PMFs) is built. Then, wavelet domain filtering is performed on the signal vector value. Since the correlation signal is low in frequency and narrow in bandwidth, the noise out-of-band can be filtered out and the most of the useful signal energy is retained.Thus this process greatly improves the signal to noise ratio(SNR).Finally, the detection variable when the filtered signal goes through the combination process is constructed and the detection based on signal energy is made. Moreover, for the better retaining useful signal energy, the rule of selection of wavelet function has been made. Simulation results show the proposed method has a better detection performance than the normal code acquisition methods under the same false alarm probability.展开更多
The next generation of High Throughput Satellite(HTS)will exploit Q/V band for the feeder link and Ka band for the user link.The exploitation of multiple gateways(GWs)is a transmit diversity measure to compensate seve...The next generation of High Throughput Satellite(HTS)will exploit Q/V band for the feeder link and Ka band for the user link.The exploitation of multiple gateways(GWs)is a transmit diversity measure to compensate severe rain attenuation of Q/V band feeder links.This paper introduces a new smart gateway diversity combination scheme that combinates N-active(K=2)and N+1 diversity method in detail from the working principle,gateway switching strategy,evaluation of system availability and implementation complexity.In addition,a feeder link outage event prediction algorithm featuring combination scheme is given detailly based on modified time-adaptive linear regression.Compared with the existing N+P scheme,the proposed scheme can provide higher system availability and more stable user’s experience under the condition of properly increasing the complexity of payload design.Compared with Nactive scheme that has been reported,it is much easier to implement in engineering and more cost-effective.As a result,the combination scheme is a realistic solution based on a trade-off between performance improvement and implementation complexity.展开更多
The English translation level of domestic film and television animation not only affects the appreciation effect of English-speaking audiences,but also affects the communication and exchange of Chinese excellent cultu...The English translation level of domestic film and television animation not only affects the appreciation effect of English-speaking audiences,but also affects the communication and exchange of Chinese excellent culture in the world,and even affects the commercial interests of film and television production.With the increasing international exchange of various cultures,the traditional theoretical views on translation are no longer suitable for the enrichment and development of modern literary forms.Based on the Skopos Theory,this paper will discuss the translation strategies of film and television animation works and propose the translation methods of film and television animation,to enhance the communication and influence of Chinese culture.展开更多
The article takes the famous American writer and mythology scholar Joseph Campbell’s“Heroic Journey”theory as a clue to make a comparative study of“Braveheart”and“Wolf Warriors II”and analyze the cultural diffe...The article takes the famous American writer and mythology scholar Joseph Campbell’s“Heroic Journey”theory as a clue to make a comparative study of“Braveheart”and“Wolf Warriors II”and analyze the cultural differences on heroic shaping between the Chinese and English.展开更多
Surface incident shortwave radiation(Rs)can promote the circulation of substance and energy,and the accuracy of its estimation is of great significance for climate studies.The Rs can be acquired from satellite retriev...Surface incident shortwave radiation(Rs)can promote the circulation of substance and energy,and the accuracy of its estimation is of great significance for climate studies.The Rs can be acquired from satellite retrievals,reanalysis predictions and general circulation model(GCM)simulations.Although Rs estimates have been evaluated and compared in previous studies,most of them focus on evaluating the Rs estimates over specific regions using ground measurements from limited stations.Therefore,it is essential to comprehensively validate Rs estimates from multiple data sources.In this study,ground measurements of 690 stations from BSRN,GEBA,CMA,GC-NET and buoys were employed to validate the Rs estimates from seven representative products(GLASS,GEWEX-SRB,CERES-EBAF,ERA5,MERRA2,CFSR and CMIP6).The validation results indicated that the selected products overestimated Rs globally,with biases ranged from 0.48 to 21.27 W/m^(2).The satellite retrievals showed relatively better accuracy among seven datasets compared to ground measurements at the selected stations.Moreover,the selected seven products were all in poor accuracy at high-latitude regions with RMSEs greater than 50 W/m^(2).The long-term variation trends were also analyzed in this study.展开更多
Bimetallic alloys could form three typical structures including solid solution,heterostructure,and intermetallic compound,depending on the interactions between identical and different atoms.Although the trend can be p...Bimetallic alloys could form three typical structures including solid solution,heterostructure,and intermetallic compound,depending on the interactions between identical and different atoms.Although the trend can be predicted by the types of binary phase diagram,different synthetic protocols will trap the system in various kinetic intermediates among the three typical structures.Herein,we studied the phase evolution and elemental segregation in the alloy nanoparticles of immiscible Pd-Ru before and after thermal annealing.By developing an analysis method of local element segregation(LES)based on the energy dispersive spectroscopy(EDS)mapping signals,we were able to quantify the mixing of Pd and Ru atoms during the gradual phase transition from face-centered cubic(fcc)to hexagonal close packed(hcp).Density functional theory was also applied to calculate the energies of all possible PdRu4 structures(93 fcc models and 267 hcp models),which helps to rationalize the phase transition and element segregation.The annealing process also leads to the change of the electronic structure,which further influences the performance in the electrocatalytic hydrogen evolution reaction.The highest activity of PdRu4-400 was largely attributed to the proper interface between the Pd-rich fcc phase and Ru-rich hcp phase,as revolved by the above methods.展开更多
The point segmentation of power lines and towers aims to use unmanned aerial vehicles(UAVs)for the inspection of power facilities,risk detection and modelling.Because of the unclear spatial relationship between the po...The point segmentation of power lines and towers aims to use unmanned aerial vehicles(UAVs)for the inspection of power facilities,risk detection and modelling.Because of the unclear spatial relationship between the point clouds,the point segmentation of power lines and towers is challenging.In this paper,the power line and tower point datasets are constructed using Light Detection and Ranging(LiDAR)and a point segmentation method is proposed based on multiscale density features and a point-based deep learning network.First,the data are blocked and the neighbourhood is constructed.Second,the point clouds are downsampled to produce sparse point clouds.The point clouds before and after sampling are rotated,and their density is calculated.Next,a direct mapping method is selected to fuse the density information;a lightweight network is built to learn the features.Finally,the point clouds are segmented by concatenating the local features provided by PointCNN.The algorithm performs effectively on different types of power lines and towers.The mean interaction over union is 82.73%,and the overall accuracy can reach 91.76%.This approach can achieve the end-to-end integration of segmentation and provide theoretical support for the segmentation of large scenic point clouds.展开更多
Artificial synapses are electronic devices that simulate important functions of biological synapses,and therefore are the basic components of artificial neural morphological networks for brain-like computing.One of th...Artificial synapses are electronic devices that simulate important functions of biological synapses,and therefore are the basic components of artificial neural morphological networks for brain-like computing.One of the most important objectives for developing artificial synapses is to simulate the characteristics of biological synapses as much as possible,especially their self-adaptive ability to external stimuli.Here,we have successfully developed an artificial synapse with multiple synaptic functions and highly adaptive characteristics based on a simple SrTiO_(3)/Nb:SrTiO_(3)heterojunction type memristor.Diverse functions of synaptic learning,such as short-term/long-term plasticity(STP/LTP),transition from STP to LTP,learning–forgetting–relearning behaviors,associative learning and dynamic filtering,are all bio-realistically implemented in a single device.The remarkable synaptic performance is attributed to the fascinating inherent dynamics of oxygen vacancy drift and diffusion,which give rise to the coexistence of volatile-and nonvolatile-type resistive switching.This work reports a multi-functional synaptic emulator with advanced computing capability based on a simple heterostructure,showing great application potential for a compact and low-power neuromorphic computing system.展开更多
The geothermal resources in the southwest section of the Mid-Spine Belt of Beautiful China are abundant,but the quantitative prediction and evaluation of geothermal resources are very difficult. Based on geographic in...The geothermal resources in the southwest section of the Mid-Spine Belt of Beautiful China are abundant,but the quantitative prediction and evaluation of geothermal resources are very difficult. Based on geographic information system (GIS) and remote sensing (RS) platforms,six impact factors,namely land surface temperature,fault density,Gutenberg–Liszt B value,formation combination entropy,distance to river and aeromagnetic anomaly were selected. Through the establishment of the certainty factor model (CF),weights of the information entropy certainty factor model (ICF) and weights of the evidence certainty factor model (ECF),the geothermal potential in the study area were predicted quantitatively. Based on the ECF results,the six main geothermal resource areas were delineated. The results show that (1) ECF had high prediction accuracy (success index is 0.00405%,area ratio is 0.867);(2) The geothermal resource areas obtained were Ganzi–Ya’an–Liangshan,Panzhihua–Liangshan,Dali–Chuxiong,Nujiang–Baoshan,Diqing–Dali,and Lijiang–Diqing. The results provide a basis for the effective development and utilization of geothermal resources in the southwest section of the mid-ridge belt.展开更多
Nonpharmaceutical interventions(NPIs)have been commonly deployed to prevent and control the spread of the coronavirus disease 2019(COVID-19),resulting in a worldwide decline in influenza prevalence.However,the influen...Nonpharmaceutical interventions(NPIs)have been commonly deployed to prevent and control the spread of the coronavirus disease 2019(COVID-19),resulting in a worldwide decline in influenza prevalence.However,the influenza risk in China warrants cautious assessment.We conducted a cross-sectional,seroepidemiological study in Shandong Province,Northern China in mid-2021.Hemagglutination inhibition was performed to test antibodies against four influenza vaccine strains.A combination of descriptive and meta-analyses was adopted to compare the seroprevalence of influenza antibodies before and during the COVID-19 pandemic.The overall seroprevalence values against A/H1N1pdm09,A/H3N2,B/Victoria,and B/Yamagata were 17.8%(95%CI 16.2%–19.5%),23.5%(95%CI 21.7%–25.4%),7.6%(95%CI 6.6%–8.7%),and 15.0(95%CI 13.5%–16.5%),respectively,in the study period.The overall vaccination rate was extremely low(2.6%).Our results revealed that antibody titers in vaccinated participants were significantly higher than those in unvaccinated individuals(P<0.001).Notably,the meta-analysis showed that antibodies against A/H1N1pdm09 and A/H3N2 were significantly low in adults after the COVID-19 pandemic(P<0.01).Increasing vaccination rates and maintaining NPIs are recommended to prevent an elevated influenza risk in China.展开更多
3-Roller bending is a widely applied manufacturing process, particularly in structural steel pipe industry.However, due to the difficulty and high cost of measuring stress distribution inside sheet material via tradit...3-Roller bending is a widely applied manufacturing process, particularly in structural steel pipe industry.However, due to the difficulty and high cost of measuring stress distribution inside sheet material via traditional method,internal stress/strain response during forming is largely unexplored. The focuses of this study are two:(1) to map the radii of curvature as well as the stress inside the work piece during forming by utilizing the meshing mechanism of finite element method, and(2) to further provide some numeric guidelines for the configuration of the rolling system in order to improve production efficiency and product quality. The results of this study indicate that:(1) it is crucial to properly choose forming parameter in order to produce product with desired radii;(2) much like a gradual springback process, the radii of curvature gradually increase from the top roller to the exit-side bottom roller;(3) under the assumptions made in this study, to produce pipes with a specified diameter with varying configurations of the 3-roller system will not significantly change the final residual stress; and(4) finally, shifting of the neutral axis up to 2.0% of the thickness toward the compressing side during the forming process is observed.展开更多
Fuel spray characteristics directly determine the formation pattern and quality of the fuel/air mixture in an engine,and thus affect the combustion process.For this reason,the improvement and optimization of fuel inje...Fuel spray characteristics directly determine the formation pattern and quality of the fuel/air mixture in an engine,and thus affect the combustion process.For this reason,the improvement and optimization of fuel injection systems is crucial to the development of engine technologies.The fuel jet breakup and atomization process is a complex liquid-gas two-phase turbulent flow system that has not yet been fully elucidated.Owing to the limitations of standard optical measurement techniques,the spray breakup mechanism and its interaction with the nozzle internal flow are still unclear.However,in recent years synchrotron radiation(SR)X-ray imaging technologies have been widely applied in engine fuel injection studies because of the higher energy and brilliance of third-generation SR light sources.This review provides a brief introduction to the development of SR technology and compares the critical parameters of the primary third-generation SR light sources available worldwide.The basic principles and applications of various X-ray imaging technologies with regard to nozzle internal structure measurements,visualization of in-nozzle flow characteristics and quantitative analyses of near-field spray transient dynamics are examined in detail.展开更多
Carbon nanogels(CNGs)with dual ability of reactive oxygen species(ROS)imaging and photodynamic therapy have been designed with selfassembled chemiluminescent carbonized polymer dots(CPDs).With efficient deep-red/near-...Carbon nanogels(CNGs)with dual ability of reactive oxygen species(ROS)imaging and photodynamic therapy have been designed with selfassembled chemiluminescent carbonized polymer dots(CPDs).With efficient deep-red/near-infrared chemiluminescence(CL)emission and distinctive photodynamic capacity,the H2O2-driven chemiluminescent CNGs are further designed by assembling the polymeric conjugate and CL donors,enabling an in vitro and in vivo ROS bioimaging capability in animal inflammation models and a high-performance therapy for xenograft tumors.Mechanistically,ROS generated in inflammatory sites or tumor microenvironment can trigger the chemically initiated electron exchange luminescence in the chemical reaction of peroxalate and H2O2,enabling in vivo CL imaging.Meanwhile,part of the excited-state electrons will transfer to the ambient H2O or dissolved oxygen and in turn lead to the type I and type II photochemical ROS production of hydroxyl radicals or singlet oxygen,endowing the apoptosis of tumor cells and thus enabling cancer therapy.These results open up a new avenue for the design of multifunctional nanomaterials for bioimaging and antienoplastic agents.展开更多
We applied the combination of in situ electrochemical liquid-phase microextraction and square-wave voltammetric stripping analysis for the first time as a highly sensitive and selective approach for the detection of d...We applied the combination of in situ electrochemical liquid-phase microextraction and square-wave voltammetric stripping analysis for the first time as a highly sensitive and selective approach for the detection of dopamine. A mixed gel of graphene sheets and an ionic liquid of 1-octyl-3-methylimidazolium hexaflurophosphate(OMim PF6) was used as a micro liquid-phase to pre-concentrate dopamine by controlled potential electrolysis from an aqueous solution(as a donor phase), followed by square-wave voltammetric stripping detection. Under optimized conditions, a linear calibration curve was obtained in the range of 0.05 to 1.0 ?mol/L in the presence of excess ascorbic acid and uric acid. The detection limit has been found to be 8.0 nmol/L(S/N=3).展开更多
基金This project has received funding from the Deutsche Forschungsgemeinschaft(SCHI 504/15-1 and YO 299/1-1),the European Community's Seventh Framework Programme under grant agreement no.602300(SYBIL),and the German Federal Ministry of Education and Research(BMBF)within the project"Detection and Individualized Management of Early Onset Osteoporosis(DIMEOS)"Parts of this work were supported by the Deutsche Forschungsgemeinschaft through FOR 2722 to O.S.(SE2373/1-1)W.Z.received funding through the China Scholarship Council.
文摘The recent identification of homozygous WNT1 mutations in individuals with osteogenesis imperfecta type XV(OI-XV)has suggested that WNT1 is a key ligand promoting the differentiation and function of bone-forming osteoblasts.Although such aninfluence was supported by subsequent studies,a mouse model of OI-XV remained to be established.Therefore,we introduced a previously identified disease-causing mutation(G177C)into the murine Wnt1 gene.Homozygous Wnt1^(G177C/G177C)mice were viable and did not display defects in brain development,but the majority of 24-week-old Wnt1^(G177C/G177C)mice had skeletal fractures.This increased bone fragility was not fully explained by reduced bone mass but also by impaired bone matrix quality.Importantly,the homozygous presence of the G177C mutation did not interfere with the osteoanabolic influence of either parathyroid hormone injection or activating mutation of LRP5,the latter mimicking the effect of sclerostin neutralization.Finally,transcriptomic analyses revealed that short-term administration of WNT1 to osteogenic cells induced not only the expression of canonical WNT signaling targets but also the expression of genes encoding extracellular matrix modifiers.Taken together,our data demonstrate that regulating bone matrix quality is a primary function of WNT1.They further suggest that individuals with WNT1 mutations should profit from existing osteoanabolic therapies.
基金supported by Educational Commission of Jilin Province of China(Grant No.JJKH20190782SK)supported by the Jilin Vocational and Technical Education Association(Grant No.2018XHY115).
文摘Based on the previous case study in promoting transformative learning of college English teachers,who participated in a three-month online training courses,the article made a further research and concluded four strategies on promoting transformative learning of college English Teachers.
基金supported by the National Natural Science Foundation of China(6117213861401340)the Fundamental Research Funds for the Central Universities(K5051302015)
文摘In order to improve the acquisition probability of satellite navigation signals, this paper proposes a novel code acquisition method based on wavelet transform filtering. Firstly, the signal vector based on the signal passing through a set of partial matched filters(PMFs) is built. Then, wavelet domain filtering is performed on the signal vector value. Since the correlation signal is low in frequency and narrow in bandwidth, the noise out-of-band can be filtered out and the most of the useful signal energy is retained.Thus this process greatly improves the signal to noise ratio(SNR).Finally, the detection variable when the filtered signal goes through the combination process is constructed and the detection based on signal energy is made. Moreover, for the better retaining useful signal energy, the rule of selection of wavelet function has been made. Simulation results show the proposed method has a better detection performance than the normal code acquisition methods under the same false alarm probability.
基金supported by the Key Pre-Research Project for Civil Space Technology(No.B0106).
文摘The next generation of High Throughput Satellite(HTS)will exploit Q/V band for the feeder link and Ka band for the user link.The exploitation of multiple gateways(GWs)is a transmit diversity measure to compensate severe rain attenuation of Q/V band feeder links.This paper introduces a new smart gateway diversity combination scheme that combinates N-active(K=2)and N+1 diversity method in detail from the working principle,gateway switching strategy,evaluation of system availability and implementation complexity.In addition,a feeder link outage event prediction algorithm featuring combination scheme is given detailly based on modified time-adaptive linear regression.Compared with the existing N+P scheme,the proposed scheme can provide higher system availability and more stable user’s experience under the condition of properly increasing the complexity of payload design.Compared with Nactive scheme that has been reported,it is much easier to implement in engineering and more cost-effective.As a result,the combination scheme is a realistic solution based on a trade-off between performance improvement and implementation complexity.
文摘The English translation level of domestic film and television animation not only affects the appreciation effect of English-speaking audiences,but also affects the communication and exchange of Chinese excellent culture in the world,and even affects the commercial interests of film and television production.With the increasing international exchange of various cultures,the traditional theoretical views on translation are no longer suitable for the enrichment and development of modern literary forms.Based on the Skopos Theory,this paper will discuss the translation strategies of film and television animation works and propose the translation methods of film and television animation,to enhance the communication and influence of Chinese culture.
文摘The article takes the famous American writer and mythology scholar Joseph Campbell’s“Heroic Journey”theory as a clue to make a comparative study of“Braveheart”and“Wolf Warriors II”and analyze the cultural differences on heroic shaping between the Chinese and English.
基金supported by the National Natural Science Foundation of China(82027802,82171304,82071466,81771260,81871022,82071468,and 82201618)“Sail Plan”Key Medical Specialty(ZYLX202139)+2 种基金“Mission”Talent Project of Beijing Municipal Administration of Hospitals(SML20150802)Beijing Municipal Science and Technology Project(Z181100001918026)Technological Innovation and Service Capability Construction Project From Beijing Municipal Commission of Education(11000023T000002157177)。
基金supported by the National Natural Science Foundation of China Major Program[Grant Number 42192584]the National Key Research and Development Program pf China[Grant Number 2020YFA0608702]the National Natural Science Foundation of China[Grant Number 42171320].
文摘Surface incident shortwave radiation(Rs)can promote the circulation of substance and energy,and the accuracy of its estimation is of great significance for climate studies.The Rs can be acquired from satellite retrievals,reanalysis predictions and general circulation model(GCM)simulations.Although Rs estimates have been evaluated and compared in previous studies,most of them focus on evaluating the Rs estimates over specific regions using ground measurements from limited stations.Therefore,it is essential to comprehensively validate Rs estimates from multiple data sources.In this study,ground measurements of 690 stations from BSRN,GEBA,CMA,GC-NET and buoys were employed to validate the Rs estimates from seven representative products(GLASS,GEWEX-SRB,CERES-EBAF,ERA5,MERRA2,CFSR and CMIP6).The validation results indicated that the selected products overestimated Rs globally,with biases ranged from 0.48 to 21.27 W/m^(2).The satellite retrievals showed relatively better accuracy among seven datasets compared to ground measurements at the selected stations.Moreover,the selected seven products were all in poor accuracy at high-latitude regions with RMSEs greater than 50 W/m^(2).The long-term variation trends were also analyzed in this study.
基金supported by the National Natural Science Foundation of China (22175127)the Institute of Energy, Hefei Comprehensive National Science Center (19KZS207)。
基金This work was financially supported by the National Natural Science Foundation of Tianjin,China(No.22175127)Institute of Energy,Hefei Comprehensive National Science Center(No.19KZS207).
文摘Bimetallic alloys could form three typical structures including solid solution,heterostructure,and intermetallic compound,depending on the interactions between identical and different atoms.Although the trend can be predicted by the types of binary phase diagram,different synthetic protocols will trap the system in various kinetic intermediates among the three typical structures.Herein,we studied the phase evolution and elemental segregation in the alloy nanoparticles of immiscible Pd-Ru before and after thermal annealing.By developing an analysis method of local element segregation(LES)based on the energy dispersive spectroscopy(EDS)mapping signals,we were able to quantify the mixing of Pd and Ru atoms during the gradual phase transition from face-centered cubic(fcc)to hexagonal close packed(hcp).Density functional theory was also applied to calculate the energies of all possible PdRu4 structures(93 fcc models and 267 hcp models),which helps to rationalize the phase transition and element segregation.The annealing process also leads to the change of the electronic structure,which further influences the performance in the electrocatalytic hydrogen evolution reaction.The highest activity of PdRu4-400 was largely attributed to the proper interface between the Pd-rich fcc phase and Ru-rich hcp phase,as revolved by the above methods.
基金Chengdu University of Technology Postgraduate Innovative Cultivation Program(CDUT2022BJCX015).
文摘The point segmentation of power lines and towers aims to use unmanned aerial vehicles(UAVs)for the inspection of power facilities,risk detection and modelling.Because of the unclear spatial relationship between the point clouds,the point segmentation of power lines and towers is challenging.In this paper,the power line and tower point datasets are constructed using Light Detection and Ranging(LiDAR)and a point segmentation method is proposed based on multiscale density features and a point-based deep learning network.First,the data are blocked and the neighbourhood is constructed.Second,the point clouds are downsampled to produce sparse point clouds.The point clouds before and after sampling are rotated,and their density is calculated.Next,a direct mapping method is selected to fuse the density information;a lightweight network is built to learn the features.Finally,the point clouds are segmented by concatenating the local features provided by PointCNN.The algorithm performs effectively on different types of power lines and towers.The mean interaction over union is 82.73%,and the overall accuracy can reach 91.76%.This approach can achieve the end-to-end integration of segmentation and provide theoretical support for the segmentation of large scenic point clouds.
基金the National Key Research&Development Program of China(No.2021YFB3601504)the National Natural Science Foundation of China(Nos.52072218,12222414,12074416)+2 种基金the Natural Science Foundation of Shandong province(Nos.ZR2022YQ43 and ZR2020ZD28)Heilongjiang Provincial Natural Resources Foundation Joint Guide Project(No.LH2020E098)Peixin Fund of Qilu University of Technology(Shandong Academy of Sciences)(No.2023PY093).
文摘Artificial synapses are electronic devices that simulate important functions of biological synapses,and therefore are the basic components of artificial neural morphological networks for brain-like computing.One of the most important objectives for developing artificial synapses is to simulate the characteristics of biological synapses as much as possible,especially their self-adaptive ability to external stimuli.Here,we have successfully developed an artificial synapse with multiple synaptic functions and highly adaptive characteristics based on a simple SrTiO_(3)/Nb:SrTiO_(3)heterojunction type memristor.Diverse functions of synaptic learning,such as short-term/long-term plasticity(STP/LTP),transition from STP to LTP,learning–forgetting–relearning behaviors,associative learning and dynamic filtering,are all bio-realistically implemented in a single device.The remarkable synaptic performance is attributed to the fascinating inherent dynamics of oxygen vacancy drift and diffusion,which give rise to the coexistence of volatile-and nonvolatile-type resistive switching.This work reports a multi-functional synaptic emulator with advanced computing capability based on a simple heterostructure,showing great application potential for a compact and low-power neuromorphic computing system.
基金funded by National Key Research and Development Program of China (2017YFC0601500,2017YFC0601502)Strategic Priority Research Program of the Chinese Academy of Sciences (grant number XDA19090121)+1 种基金National Natural Science Foundation of China (42002298)Key Research and Development Program of Sichuan Provincial Science and Technology Department (2022YFS0486).
文摘The geothermal resources in the southwest section of the Mid-Spine Belt of Beautiful China are abundant,but the quantitative prediction and evaluation of geothermal resources are very difficult. Based on geographic information system (GIS) and remote sensing (RS) platforms,six impact factors,namely land surface temperature,fault density,Gutenberg–Liszt B value,formation combination entropy,distance to river and aeromagnetic anomaly were selected. Through the establishment of the certainty factor model (CF),weights of the information entropy certainty factor model (ICF) and weights of the evidence certainty factor model (ECF),the geothermal potential in the study area were predicted quantitatively. Based on the ECF results,the six main geothermal resource areas were delineated. The results show that (1) ECF had high prediction accuracy (success index is 0.00405%,area ratio is 0.867);(2) The geothermal resource areas obtained were Ganzi–Ya’an–Liangshan,Panzhihua–Liangshan,Dali–Chuxiong,Nujiang–Baoshan,Diqing–Dali,and Lijiang–Diqing. The results provide a basis for the effective development and utilization of geothermal resources in the southwest section of the mid-ridge belt.
基金supported by the Academic Promotion Programme of Shandong First Medical University(No.2019QL006)the Natural Science Foundation of Shandong Province(Nos.ZR2020QH133,ZR2020MH339,and ZR2021MC001).
文摘Nonpharmaceutical interventions(NPIs)have been commonly deployed to prevent and control the spread of the coronavirus disease 2019(COVID-19),resulting in a worldwide decline in influenza prevalence.However,the influenza risk in China warrants cautious assessment.We conducted a cross-sectional,seroepidemiological study in Shandong Province,Northern China in mid-2021.Hemagglutination inhibition was performed to test antibodies against four influenza vaccine strains.A combination of descriptive and meta-analyses was adopted to compare the seroprevalence of influenza antibodies before and during the COVID-19 pandemic.The overall seroprevalence values against A/H1N1pdm09,A/H3N2,B/Victoria,and B/Yamagata were 17.8%(95%CI 16.2%–19.5%),23.5%(95%CI 21.7%–25.4%),7.6%(95%CI 6.6%–8.7%),and 15.0(95%CI 13.5%–16.5%),respectively,in the study period.The overall vaccination rate was extremely low(2.6%).Our results revealed that antibody titers in vaccinated participants were significantly higher than those in unvaccinated individuals(P<0.001).Notably,the meta-analysis showed that antibodies against A/H1N1pdm09 and A/H3N2 were significantly low in adults after the COVID-19 pandemic(P<0.01).Increasing vaccination rates and maintaining NPIs are recommended to prevent an elevated influenza risk in China.
基金the financial support provided by the LSU Graduate School through the Economic Development Award
文摘3-Roller bending is a widely applied manufacturing process, particularly in structural steel pipe industry.However, due to the difficulty and high cost of measuring stress distribution inside sheet material via traditional method,internal stress/strain response during forming is largely unexplored. The focuses of this study are two:(1) to map the radii of curvature as well as the stress inside the work piece during forming by utilizing the meshing mechanism of finite element method, and(2) to further provide some numeric guidelines for the configuration of the rolling system in order to improve production efficiency and product quality. The results of this study indicate that:(1) it is crucial to properly choose forming parameter in order to produce product with desired radii;(2) much like a gradual springback process, the radii of curvature gradually increase from the top roller to the exit-side bottom roller;(3) under the assumptions made in this study, to produce pipes with a specified diameter with varying configurations of the 3-roller system will not significantly change the final residual stress; and(4) finally, shifting of the neutral axis up to 2.0% of the thickness toward the compressing side during the forming process is observed.
基金This study was supported by the National Natural Science Foundation(U1832179)as a Key Project of the SSRF(2016-SSRF-ZD-004512).
文摘Fuel spray characteristics directly determine the formation pattern and quality of the fuel/air mixture in an engine,and thus affect the combustion process.For this reason,the improvement and optimization of fuel injection systems is crucial to the development of engine technologies.The fuel jet breakup and atomization process is a complex liquid-gas two-phase turbulent flow system that has not yet been fully elucidated.Owing to the limitations of standard optical measurement techniques,the spray breakup mechanism and its interaction with the nozzle internal flow are still unclear.However,in recent years synchrotron radiation(SR)X-ray imaging technologies have been widely applied in engine fuel injection studies because of the higher energy and brilliance of third-generation SR light sources.This review provides a brief introduction to the development of SR technology and compares the critical parameters of the primary third-generation SR light sources available worldwide.The basic principles and applications of various X-ray imaging technologies with regard to nozzle internal structure measurements,visualization of in-nozzle flow characteristics and quantitative analyses of near-field spray transient dynamics are examined in detail.
基金the National Natural Science Foundation of China(Nos.12074348,U2004168,U1904142,and U21A2070)the China Postdoctoral Science Foundation(No.2020M682310)+1 种基金the Natural Science Foundation of Henan Province(No.212300410078)Science and Technology Department of Henan Province(No.182102410010).
文摘Carbon nanogels(CNGs)with dual ability of reactive oxygen species(ROS)imaging and photodynamic therapy have been designed with selfassembled chemiluminescent carbonized polymer dots(CPDs).With efficient deep-red/near-infrared chemiluminescence(CL)emission and distinctive photodynamic capacity,the H2O2-driven chemiluminescent CNGs are further designed by assembling the polymeric conjugate and CL donors,enabling an in vitro and in vivo ROS bioimaging capability in animal inflammation models and a high-performance therapy for xenograft tumors.Mechanistically,ROS generated in inflammatory sites or tumor microenvironment can trigger the chemically initiated electron exchange luminescence in the chemical reaction of peroxalate and H2O2,enabling in vivo CL imaging.Meanwhile,part of the excited-state electrons will transfer to the ambient H2O or dissolved oxygen and in turn lead to the type I and type II photochemical ROS production of hydroxyl radicals or singlet oxygen,endowing the apoptosis of tumor cells and thus enabling cancer therapy.These results open up a new avenue for the design of multifunctional nanomaterials for bioimaging and antienoplastic agents.
基金financially supported by the National Natural Science Foundation of China(21335001,21075004)
文摘We applied the combination of in situ electrochemical liquid-phase microextraction and square-wave voltammetric stripping analysis for the first time as a highly sensitive and selective approach for the detection of dopamine. A mixed gel of graphene sheets and an ionic liquid of 1-octyl-3-methylimidazolium hexaflurophosphate(OMim PF6) was used as a micro liquid-phase to pre-concentrate dopamine by controlled potential electrolysis from an aqueous solution(as a donor phase), followed by square-wave voltammetric stripping detection. Under optimized conditions, a linear calibration curve was obtained in the range of 0.05 to 1.0 ?mol/L in the presence of excess ascorbic acid and uric acid. The detection limit has been found to be 8.0 nmol/L(S/N=3).