The maintenance of the mammalian blood system depends on hematopoietic stem cells(HSCs),which are a rare class of adult stem cells with self-renewal and multilineage differentiation capacities.The homeostasis of hemat...The maintenance of the mammalian blood system depends on hematopoietic stem cells(HSCs),which are a rare class of adult stem cells with self-renewal and multilineage differentiation capacities.The homeostasis of hematopoietic stem cells is finely tuned by a variety of endogenous and exogenous regulatory factors,and disrupted balance will lead to hematological diseases including leukemia and anemia.Recently,emerging studies have illustrated the cellular and molecular mechanisms underlying the regulation of HSC homeostasis.Particularly,the rapid development of second-generation sequencing technologies has uncovered that many small noncoding RNAs(ncRNAs)are highly expressed in HSCs,including snoRNAs,miRNAs,tsRNAs,circular RNAs,etc.In this study,we will summarize the essential roles and regulatory mechanisms of these small ncRNAs in maintaining HSC homeostasis.Overall,this review provides up-to-date information in the regulation of HSC homeostasis by small ncRNAs,which sheds light into the development of therapeutic strategies against hematopoietic malignancies.展开更多
基金This work was supported by grants from the National Key R&D Program of China,Stem Cell and Translation Research(2018YFA0109300)the National Natural Science Foundation of China(81870080,31900815,91949115,82161138028)+1 种基金the Zhejiang Provincial Natural Science Foundation of China(LR19H080001)the Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang(2020R01006)。
文摘The maintenance of the mammalian blood system depends on hematopoietic stem cells(HSCs),which are a rare class of adult stem cells with self-renewal and multilineage differentiation capacities.The homeostasis of hematopoietic stem cells is finely tuned by a variety of endogenous and exogenous regulatory factors,and disrupted balance will lead to hematological diseases including leukemia and anemia.Recently,emerging studies have illustrated the cellular and molecular mechanisms underlying the regulation of HSC homeostasis.Particularly,the rapid development of second-generation sequencing technologies has uncovered that many small noncoding RNAs(ncRNAs)are highly expressed in HSCs,including snoRNAs,miRNAs,tsRNAs,circular RNAs,etc.In this study,we will summarize the essential roles and regulatory mechanisms of these small ncRNAs in maintaining HSC homeostasis.Overall,this review provides up-to-date information in the regulation of HSC homeostasis by small ncRNAs,which sheds light into the development of therapeutic strategies against hematopoietic malignancies.
