Because of the complex nerve anatomy and limited regeneration ability of natural tissue,the current treatment effect for long-distance peripheral nerve regeneration and spinal cord injury(SCI)repair is not satisfactor...Because of the complex nerve anatomy and limited regeneration ability of natural tissue,the current treatment effect for long-distance peripheral nerve regeneration and spinal cord injury(SCI)repair is not satisfactory.As an alternative method,tissue engineering is a promising method to regenerate peripheral nerve and spinal cord,and can provide structures and functions similar to natural tissues through scaffold materials and seed cells.Recently,the rapid development of 3D printing technology enables researchers to create novel 3D constructs with sophisticated structures and diverse functions to achieve high bionics of structures and functions.In this review,we first outlined the anatomy of peripheral nerve and spinal cord,as well as the current treatment strategies for the peripheral nerve injury and SCI in clinical.After that,the design considerations of peripheral nerve and spinal cord tissue engineering were discussed,and various 3D printing technologies applicable to neural tissue engineering were elaborated,including inkjet,extrusion-based,stereolithography,projection-based,and emerging printing technologies.Finally,we focused on the application of 3D printing technology in peripheral nerve regeneration and spinal cord repair,as well as the challenges and prospects in this research field.展开更多
In this letter,the streamer propagation in the atmospheric pressure helium plasma jet with afloating electrode nozzle driven by the kHz AC power supply is investigated.The current signal induced by the space charges a...In this letter,the streamer propagation in the atmospheric pressure helium plasma jet with afloating electrode nozzle driven by the kHz AC power supply is investigated.The current signal induced by the space charges and the mean propagation velocity of the guided ionization waves are measured by the capacitive probe method in the discharge region.The space charges in the guided ionization waves are found to increase with the applied voltage,which enhances both the electric field near the streamer head and the propagation velocity.The applicability of the streamer mechanism to the propagation of the guided ionization waves is validated by this electrical diagnostic method.展开更多
基金financially sponsored by the National Key Research and Development Program of China(2018YFA0703000)the National Natural Science Foundation of China(No.U1909218)+2 种基金the Joint Funds of Guangdong Basic and Applied Basic Research Foundation(2019A1515110261)the Special Projects in Key Fields from the Department of Education of Guangdong Province(2022ZDZX2059)the Dongguan Science and Technology of Social Development Program(20221800905072)。
文摘Because of the complex nerve anatomy and limited regeneration ability of natural tissue,the current treatment effect for long-distance peripheral nerve regeneration and spinal cord injury(SCI)repair is not satisfactory.As an alternative method,tissue engineering is a promising method to regenerate peripheral nerve and spinal cord,and can provide structures and functions similar to natural tissues through scaffold materials and seed cells.Recently,the rapid development of 3D printing technology enables researchers to create novel 3D constructs with sophisticated structures and diverse functions to achieve high bionics of structures and functions.In this review,we first outlined the anatomy of peripheral nerve and spinal cord,as well as the current treatment strategies for the peripheral nerve injury and SCI in clinical.After that,the design considerations of peripheral nerve and spinal cord tissue engineering were discussed,and various 3D printing technologies applicable to neural tissue engineering were elaborated,including inkjet,extrusion-based,stereolithography,projection-based,and emerging printing technologies.Finally,we focused on the application of 3D printing technology in peripheral nerve regeneration and spinal cord repair,as well as the challenges and prospects in this research field.
基金supported by National Natural Science Foundation of China(Nos.10775087 and51907190)the State Key Laboratory of NBC Protection for Civilian(SKLNBC 2019–16)。
文摘In this letter,the streamer propagation in the atmospheric pressure helium plasma jet with afloating electrode nozzle driven by the kHz AC power supply is investigated.The current signal induced by the space charges and the mean propagation velocity of the guided ionization waves are measured by the capacitive probe method in the discharge region.The space charges in the guided ionization waves are found to increase with the applied voltage,which enhances both the electric field near the streamer head and the propagation velocity.The applicability of the streamer mechanism to the propagation of the guided ionization waves is validated by this electrical diagnostic method.
