Research and Design of Consistent Project Cases for the Software Engineering Course Group

In order to enhance the abilities of practical innovation and solving complex engineering problems of students in the engineering context,we design a course cluster teaching model based on a unified enterprise-level project case.The program divides the knowledge points required by the project into the corresponding courses,and divides their realization into the practical teaching cases,so as to realize the design of teaching practice cases embodied in the unified project framework.This model allows students to practice projects based on the unified project background while learning knowledge from different courses.It not only allows students to learn abstract,fragmented,and difficult-to-understand knowledge systems thoroughly,but also integrates the knowledge into the practice of the enterprise-level project development,helping students experience the value of knowledge in complex engineering projects and thus improving their ability to solve complex engineering problems while learning theoretical knowledge.

Overview of allergenic risk of novel foods

The reported cases of food allergies are steadily increasing.With the invention of more novel foods,new and unfamiliar allergens are being introduced into our diets,which raises concerns about the potential risk of novel food allergies.The purpose of this review is to assess the allergenic risks associated with novel food components,strategies for assessing risk in relation to novel food allergens,and current regulations for managing food allergens in novel food products.

Pervasive intelligent endogenous 6G wireless systems:Prospects,theories and key technologies

The worldwide large-scale commercial deployment of 5G has commenced in 2020 for supporting enhanced Mobile BroadBand(eMBB),ultra-Reliable and Low-Latency Communications(uRLLC),and massive Machine-Type Communications(mMTC)services.Nevertheless,the upsurge of Artificial Intelligence(AI)-powered applications,the developmental law of one-decade-one-generation of wireless communications and the inherent limitations of 5G have also been spurring the industry and academia to dedicate their efforts to the research of future 6G wireless systems.6G will be a disruptive,pervasive,intelligent,and endogenous wireless system,which will revolutionize all walks of life and accelerate the transformation and innovation of the global society.In this paper,we present a forward-looking,comprehensive and in-depth analysis and technical identification of 6G.Specifically,we firstly introduce the fundamental theories of 6G in terms of potential requirements.Then,we focus our attention on the discussion of promising key technologies in terms of spectrum,air interface,delay,access,energy consumption,coverage,AI,electromagnetism,interaction,etc.

(001)-oriented FePt/Ag composite films for perpendicular recording

FePt/Ag thin films were deposited by magnetron sputtering onto 7059 glass substrates, then were annealed at 550 ℃ for 30 min. Nanostructured FePt/Ag films were successfully obtained with the magnetic easy axis of L10 FePt perpendicular to the film plane. It was found that the development of （001） texture depended strongly on the thicknesses of FePt magnetic layer and Ag underlayer. The L10 ordered FePt（15 nm）/Ag（50 nm） with （001） orientation can be obtained. And the perpendicular coercivity of FePt（15 nm）/Ag（50 nm） film reached to 7.2× 10^5 A/m, whereas the longitudinal one was only 3.2×10^4 A/m. The non-magnetic Ag underlayer can not only induce （001） orientation and ordering of FePt grains, but also reduce the intergrain interactions.

Self-Certificating Root:A Root Zone Security Enhancement Mechanism for DNS

As a critical Internet infrastructure,domain name system(DNS)protects the authenticity and integrity of domain resource records with the introduction of security extensions(DNSSEC).DNSSEC builds a single-center and hierarchical resource authentication architecture,which brings management convenience but places the DNS at risk from a single point of failure.When the root key suffers a leak or misconfiguration,top level domain(TLD)authority cannot independently protect the authenticity of TLD data in the root zone.In this paper,we propose self-certificating root,a lightweight security enhancement mechanism of root zone compatible with DNS/DNSSEC protocol.By adding the TLD public key and signature of the glue records to the root zone,this mechanism enables the TLD authority to certify the self-submitted data in the root zone and protects the TLD authority from the risk of root key failure.This mechanism is implemented on an open-source software,namely,Berkeley Internet Name Domain(BIND),and evaluated in terms of performance,compatibility,and effectiveness.Evaluation results show that the proposed mechanism enables the resolver that only supports DNS/DNSSEC to authenticate the root zone TLD data effectively with minimal performance difference.

lncR-GAS5 upregulates the splicing factor SRSF10 to impair endothelial autophagy,leading to atherogenesis

Long noncoding RNAs(lncRNAs)play a critical role in the regulation of atherosclerosis.Here,we investigated the role of the lncRNA growth arrest-specific 5(lncR-GAS5)in atherogenesis.We found that the enforced expression of lncR-GAS5 contributed to the development of atherosclerosis,which presented as increased plaque size and reduced collagen content.Moreover,impaired autophagy was observed,as shown by a decreased LC3II/LC3I protein ratio and an elevated P62 level in lncR-GAS5-overexpressing human aortic endothelial cells.By contrast,lncR-GAS5 knockdown promoted autophagy.Moreover,serine/arginine-rich splicing factor 10(SRSF10)knockdown increased the LC3II/LC3I ratio and decreased the P62 level,thus enhancing the formation of autophagic vacuoles,autolysosomes,and autophagosomes.Mechanistically,lncR-GAS5 regulated the downstream splicing factor SRSF10 to impair autophagy in the endothelium,which was reversed by the knockdown of SRSF10.Further results revealed that overexpression of the lncR-GAS5-targeted gene miR-193-5p promoted autophagy and autophagic vacuole accumulation by repressing its direct target gene,SRSF10.Notably,miR-193-5p overexpression decreased plaque size and increased collagen content.Altogether,these findings demonstrate that lncR-GAS5 partially contributes to atherogenesis and plaque instability by impairing endothelial autophagy.In conclusion,lncR-GAS5 overexpression arrested endothelial autophagy through the miR-193-5p/SRSF10 signaling pathway.Thus,miR-193-5p/SRSF10 may serve as a novel treatment target for atherosclerosis.

Ni-catalyzed ligand-controlled divergent and selective synthesis

Scaffold diversity is a key feature of a compound library and plays a pivotal role in its success in biological screening.Therefore,it is highly desirable to develop efficient strategies to rapidly construct structurally distinct and diverse“privileged”molecular scaffolds,thereby giving rise to compound libraries with selective and differing biological activities.This review covers recent efforts in this emerging field of Ni-catalyzed divergent and selective synthesis,and will focus on reactions using the same substrate to generate structurally diverse molecular scaffolds by varying the ligand backbone under otherwise almost identical reaction conditions.We hope that the field will be encouraged by the progress achieved,drawing attention to the design and development of new selective catalytic systems,and revealing new modes of catalytic transformation for broader synthetic applications.

The potential development of drug resistance in rheumatoid arthritis patients identified with p53 mutations

Rheumatoid arthritis(RA)is a chronic inflammatory disease characterized by cartilage and bone damage with the presence of pannus formation which causes uncontrollable proliferation and invasion of fibroblast-like synoviocytes(FLS).Since rheumatoid arthritis is a chronic disorder,the patients normally need to undergo prolonged antirheumatic treatment with the use of disease-modifying antirheumatic drugs(DMARDs),steroids,and nonsteroidal anti-inflammatory drugs(NSAIDs).The efficacy of such long-term pharmaceutical intervention can be significantly affected by the development of drug resistance.The pathological relationship between rheumatoid arthritis and cancer hinted that some chemotherapeutic drugs,such as methotrexate(MTX),could be used for RA treatment.This idea was reinforced by the analysis of mutations in p53 tumor suppressor gene.Around 50%of p53 somatic mutations observed from various cancers are also identified in the synovium of RA patients1(Fig.1A).Of note,the hyperplastic synovium in RA with overexpressed p53 mutants contributed to the destruction of joints in patients with erosive RA.

一体化柔性超级电容器的研究进展

个性化柔性电子产品的兴起推动了柔性超级电容器的快速发展,这得益于它的使用寿命长、充放电速度快和操作安全等特点.不同于传统的柔性超级电容器,一体化柔性超级电容器具有低界面电阻和更耐形变的特性,因而在柔性电子领域中有更广阔的应用前景.本文简要总结了一维纤维状和二维平面状的一些典型一体化超级电容器的制备方法和电化学性能.首先介绍了传统柔性超级电容器和一体化柔性超级电容器的基本概念以及性能评估的主要参数,随后介绍了具有不同功能特征(可拉伸、自愈合和可压缩)水凝胶基和非水凝胶基一体化柔性超级电容器的研究进展,并讨论了一体化柔性超级电容器在发展中面临的挑战,且对未来的发展方向做出了展望.

Multi-step evolution and measurement control of finite-dimensional quantum systems

For finite-dimensional quantum systems,we propose a quantum control scheme based on a multi-step unitary evolution and quantum projective measurements.The objective is to design a control law to steer the system to a target eigenstate of the measurement operator in the least number of steps.Within each control step,unitary evolution and quantum projective measurement are performed in turn until the system reaches the target state.The control process can be modeled as a finite-state Markov chain with an absorbing state.We prove that the controlled system will converge to the target eigenstate with probability one after a finite number of control steps and find a minimal-step-number condition that would steer the system to the target eigenstate in the least number of steps.

Single-shot ultrafast multiplexed coherent diffraction imaging

Classic interferometry was commonly adopted to realize ultrafast phase imaging using pulsed lasers;however, the reference beam required makes the optical structure of the imaging system very complex, and high temporal resolution was reached by sacrificing spatial resolution. This study presents a type of single-shot ultrafast multiplexed coherent diffraction imaging technique to realize ultrafast phase imaging with both high spatial and temporal resolutions using a simple optical setup, and temporal resolution of nanosecond to femtosecond scale can be realized using lasers of different pulse durations. This technique applies a multiplexed algorithm to avoid the data division in space domain or frequency domain and greatly improves the spatial resolution. The advantages of this proposed technique on both the simple optical structure and high image quality were demonstrated by imaging the generation and evaluating the laser-induced damage and accompanying phenomenon of laser filament and shock wave at a spatial resolution better than 6.96 μm and a temporal resolution better than 10 ns.

Direct ink writing of conductive materials for emerging energy storage systems

Direct ink writing(DIW)has recently emerged as an appealing method for designing and fabricating three-dimensional(3D)objects.Complex 3D structures can be built layer-by-layer via digitally controlled extrusion and deposition of aqueous-based colloidal pastes.The formulation of well-dispersed suspensions with specific rheological behaviors is a prerequisite for the use of this route.In this review article,the fundamental concepts of DIW are presented,including the operation principles and basic features.Typical strategies used for ink formulation are discussed with a focus on the most widely used electrode materials,including graphene,Mxenes,and carbon nanotubes.The recent progress in printing design of emerging energy storage systems,encompassing rechargeable batteries,supercapacitors,and hybrid capacitors,is summarized.Challenges and future perspectives are also covered to provide guidance for the future development of DIW.

Portable hydrogel-based tri-channel fluorescence sensor array for visual detection of multiple explosives

The identification and detection of various types of explosives are essential for human health and environmental monitoring.Array-based sensing approach offers significant advantages in detecting multi-analytes simultaneously,thereby holding great potential in identifying multiple explosives.Here,we report a tri-channel fluorescence array composed of three distinct fluorescence probes based on gold nanoclusters and nicotinamide adenine dinucleotide with well-separated emission colors.Through the specific interactions of explosives with different fluorescent probes and the yielded response patterns,seven explosives can be successfully distinguished with 100%accuracy.In particular,the sensor array exhibits excellent performance in the quantitative analysis of individual explosive and the differentiation of multiple explosive mixtures.To facilitate the field detection towards practical application,the tri-channel fluorescence array was further integrated with polymer hydrogels.The fabricated portable hydrogel-based array sensors can not only visually identify seven different explosives by their distinct fluorescence color change,but also enable quantitative detection based on linear discriminant analysis(LDA)together with a smartphone.This study illustrates the great potential of hydrogel-based fluorescence sensor array as robust sensors for explosives,which also holds significant promise for the development of portable explosive devices towards practical application.

Lead-free(Ba,Sr)TiO_(3)-based ceramics with superior tunable properties by the semi-solution method

High-performance dielectric tunable materials with both high dielectric tunability and low dielectric loss are urgently needed for new-generation electronic tunable devices.In the present study,a new system,(Ba_(0.675)Sr_(0.325))_(1−x)La_(x)Ti_(1−x)MnxO_(3)(x=0.25%,0.5%,0.75%,and 1.0%),was designed.The acceptor dopant Mn was added to lower dielectric loss,while the donor dopant La was introduced to enhance dielectric tunability.The samples were prepared using the conventional solid-state(CS)reaction method and the semi-solution(SS)method.The experimental results showed that the morphology of the ceramics was optimized by further improving the processing procedure.Dense microstructures,homogeneous grains,and uniform dopant distributions could be achieved successfully by the semi-solution method.Moreover,a significant enhancement in the tunable properties was realized owing to the improved microstructure mentioned above.The optimum tunable properties occurred in the samples prepared by the semi-solution method at x=0.75%,with a high dielectric tunability of 85.0%,a low dielectric loss of 0.0011,and an excellent figure of merit(FOM)of 773.The tunable properties of(Ba,Sr)TiO_(3)(BST)ceramics were even superior to those of lead-based materials,with an FOM of approximately 700.All the results suggested that the semi-solution method rendered BST ceramics more promising for applications in tunable devices.