Chinese alligator hatchlings in captivity are fragile and have a high mortality rate within first year.The body mass gain of reptile animals is closely related to their feeding behavior and gut microbiota.This study a...Chinese alligator hatchlings in captivity are fragile and have a high mortality rate within first year.The body mass gain of reptile animals is closely related to their feeding behavior and gut microbiota.This study analyzed the intrinsic factors influencing the allometric growth of Chinese alligator hatchlings based on their body mass gain,feeding behavior,and gut microbiota.This information would enhance the health management of Chinese alligator hatchlings.There was a significant correlation between the total distance moved,the average number of conspecifics nearby,and body mass gain.Chinese alligator hatchlings with a greater growth rate showed greater activity and more independent behavior during feeding than those with a lower growth rate.Moreover,after feeding started,some functions of the gut microbiota showed significant relationships with growth rate and feeding activity.Chinese alligator hatchlings with a greater growth rate showed greater levels of heme biosynthesis than those with a lower growth rate,and feeding activity was inhibited by long-chain fatty acid biosynthesis.These results elucidate the relationships between health,feeding behavior,and the gut microbiota of Chinese alligator hatchlings.Understanding the intrinsic factors of their health and feeding behavior can improve the health management of Chinese alligator hatchlings in captivity for conservation.展开更多
Genetic factors play a key role in determination of the structure of the cloacal flora for newborn Chinese Alligators.We collected the cloacal microbiomes for 24 newborn Chinese Alligators from three different genetic...Genetic factors play a key role in determination of the structure of the cloacal flora for newborn Chinese Alligators.We collected the cloacal microbiomes for 24 newborn Chinese Alligators from three different genetic backgrounds for 16S gene amplicon sequencing.The number of cloacal flora for the Chinese Alligators from different groups was comparable but differed structurally.There were variations in proportions of floral compositions at the phylum and family levels;however,the main difference was at the genus level.There were two significant differences in richness and evenness among the three groups.Non-metric multidimensional scaling NMDS analysis revealed that the 24 samples could be clearly divided into three categories based on their genetic backgrounds(stress=0.0244).Thus,we postulated that newborn Chinese Alligators with different genetic backgrounds have different immune strengths,which affects individual responses to environmental microorganisms.In summary,newborn Chinese Alligators from different genetic backgrounds exhibit variations in cloacal microbiome.展开更多
The high water content of sludge has always posed significant challenges for its treatment.Synthetic flocculants,which are widely used in sewage treatment plants,can cause secondary pollution during their production a...The high water content of sludge has always posed significant challenges for its treatment.Synthetic flocculants,which are widely used in sewage treatment plants,can cause secondary pollution during their production and use.Thus,natural polymer flocculants made of natural materials have received increased research attention recently.Corncore,an agricultural waste,was modified through alkalization with sodium hydroxide(NaOH)and etherification with cetyltrimethylammonium bromide(CTMAB)in this study.The L16(45)orthogonal array was used to study the modification conditions.The moisture content(MC)of treated sludge was reduced by approximately 37%with the addition of modified corncore powder(MCCP),which was synthesized under optimal conditions.In addition,changes in the functional groups of the material before and after modification were determined by FTIR.Thermogravimetric analysis indicated that MCCP was steady at room temperature,moreover,BET analysis showed that MCCP had greater surface area.The microstructures of material before and after modification were examined by scanning electron microscopy,revealing that MCCP had a flakeshaped structure and had an increased area of contact area with sludge particles.MCCP is a dehydrating agent that can enhance sludge dewaterability through charge neutralization and reagglomeration and provide superior economic benefits.展开更多
The foundation of ad hoc networks lies in the guarantee of continuous connectivity.However,critical nodes,whose failure can easily destroy network connectivity,will influence the ad hoc network connectivity significan...The foundation of ad hoc networks lies in the guarantee of continuous connectivity.However,critical nodes,whose failure can easily destroy network connectivity,will influence the ad hoc network connectivity significantly.To protect the network efficiently,critical nodes should be identified accurately and rapidly.Unlike existing critical node identification methods for unknown topology that identify critical nodes according to historical information,this paper develops a critical node identification method to relax the prior topology information condition about critical nodes.Specifically,we first deduce a theorem about the minimum communication range for a node through the number of nodes and deployment ranges,and prove the universality of the theorem in a realistic two-dimensional scenario.After that,we analyze the relationship between communication range and degree value for each node and prove that the greater number of nodes within the communication range of a node,the greater degree value of nodes with high probability.Moreover,we develop a novel strategy to improve the accuracy of critical node identification without topology information.Finally,simulation results indicate the proposed strategy can achieve high accuracy and low redundancy while ensuring low time consumption in the scenarios with unknown topology information in ad hoc networks.展开更多
Retroperitoneal liposarcoma(RLPS)is the main subtype of retroperitoneal soft sarcoma(RSTS)and has a poor prognosis and few treatment options,except for surgery.The proteomic and metabolic profiles of RLPS have remaine...Retroperitoneal liposarcoma(RLPS)is the main subtype of retroperitoneal soft sarcoma(RSTS)and has a poor prognosis and few treatment options,except for surgery.The proteomic and metabolic profiles of RLPS have remained unclear.The aim of our study was to reveal the metabolic profile of RLPS.Here,we performed proteomic analysis(n=10),metabolomic analysis(n=51),and lipidomic analysis(n=50)of retroperitoneal dedifferentiated liposarcoma(RDDLPS)and retroperitoneal well-differentiated liposarcoma(RWDLPS)tissue and paired adjacent adipose tissue obtained during surgery.Data analysis mainly revealed that glycolysis,purine metabolism,pyrimidine metabolism and phospholipid formation were upregulated in both RDDLPS and RWDLPS tissue compared with the adjacent adipose tissue,whereas the tricarboxylic acid(TCA)cycle,lipid absorption and synthesis,fatty acid degradation and biosynthesis,as well as glycine,serine,and threonine metabolism were downregulated.Of particular importance,the glycolytic inhibitor 2-deoxy-D-glucose and pentose phosphate pathway(PPP)inhibitor RRX-001 significantly promoted the antitumor effects of the MDM2 inhibitor RG7112 and CDK4 inhibitor abemaciclib.Our study not only describes the metabolic profiles of RDDLPS and RWDLPS,but also offers potential therapeutic targets and strategies for RLPS.展开更多
In order to improve the sensitivity of the Compass B1C signal acquisition for the receiver,the principle of constant false alarm rate(CFAR)is applied for the B1C pilot channel acquisition to realize the dynamic adjust...In order to improve the sensitivity of the Compass B1C signal acquisition for the receiver,the principle of constant false alarm rate(CFAR)is applied for the B1C pilot channel acquisition to realize the dynamic adjustment of the threshold of acquisition against the carrier to noise ratio.The non-coherent data/pilot combined acquisition algorithm for B1C signal is analyzed to make full use of the power of the B1C signal under the condition of low carrier to noise ratio.On this basis,to improve the acquisition sensitivity of the receiver,the principle of constant false alarm probability is applied for the non-coherent data/pilot combined acquisition algorithm.Theoretical analysis and simulations show that the non-coherent data/pilot combined acquisition algorithm with CFAR improves the B1C signal acquisition sensitivity of the receiver significantly,and achieves a better Receiver Operating Characteristic compared with the traditional acquisition algorithms.展开更多
A joint power control and relay selection scheme is considered for a cooperative and cognitive radio system where a secondary network shares spectrum with the primary network. In the secondary network, two secondary u...A joint power control and relay selection scheme is considered for a cooperative and cognitive radio system where a secondary network shares spectrum with the primary network. In the secondary network, two secondary users (SUs) communicate with each other via an assist relay. The main point is to provide the best system performance to SUs while maintaining the interference power at primary user (PU) under a certain level. Using convex optimization, a closed-form solution is obtained when optimizing the power allocation among the two nodes and relay. Based on this result, a joint power control and relay selection scheme with fewer variable dimensions is proposed to maximize the achievable rate of the secondary system. Simulation results demonstrate that the sum rate of the cognitive two-way relay network increases compared with a random relay selection and fixed power allocation.展开更多
For reducing the inter-user interference in multi-user multiple-input multiple-output(MU-MIMO) wireless communication systems,e.g.,MIMO-orthogonal frequency division multiplexing(MIMO-OFDM) systems,it is often des...For reducing the inter-user interference in multi-user multiple-input multiple-output(MU-MIMO) wireless communication systems,e.g.,MIMO-orthogonal frequency division multiplexing(MIMO-OFDM) systems,it is often desirable to the complex preprocessing at the transmitter.This paper proposes a multi-user beamforming algorithm with sub-codebook selection.Based on the minimal leakage criterion,the codebook selection,limited feed-forward and minimum mean square error(MMSE) detection are combined in the proposed algorithm.This avoids the complex channel matrix decomposition and inversion.Consequently,the computational complexity at the transmitter is significantly reduced.Simulation results show that the proposed algorithm performs better than existing beamforming algorithms.展开更多
Dear Editor,Soft tissue sarcomas are a heterogeneous group of rare malignancies with mesenchymal origin that can arise at any anatomic site.They account for almost 1.5% of all malignancies in humans,with an increased ...Dear Editor,Soft tissue sarcomas are a heterogeneous group of rare malignancies with mesenchymal origin that can arise at any anatomic site.They account for almost 1.5% of all malignancies in humans,with an increased incidence in young adults[1,2].The retroperitoneum is the primary site of 15%-20% of soft tissue sarcomas[3,4].展开更多
基金supported by the National Natural Science Foundation of China(Nos.32000355,32170525,32370561)Anhui Science and Technology Major Project(202003a06020028).
文摘Chinese alligator hatchlings in captivity are fragile and have a high mortality rate within first year.The body mass gain of reptile animals is closely related to their feeding behavior and gut microbiota.This study analyzed the intrinsic factors influencing the allometric growth of Chinese alligator hatchlings based on their body mass gain,feeding behavior,and gut microbiota.This information would enhance the health management of Chinese alligator hatchlings.There was a significant correlation between the total distance moved,the average number of conspecifics nearby,and body mass gain.Chinese alligator hatchlings with a greater growth rate showed greater activity and more independent behavior during feeding than those with a lower growth rate.Moreover,after feeding started,some functions of the gut microbiota showed significant relationships with growth rate and feeding activity.Chinese alligator hatchlings with a greater growth rate showed greater levels of heme biosynthesis than those with a lower growth rate,and feeding activity was inhibited by long-chain fatty acid biosynthesis.These results elucidate the relationships between health,feeding behavior,and the gut microbiota of Chinese alligator hatchlings.Understanding the intrinsic factors of their health and feeding behavior can improve the health management of Chinese alligator hatchlings in captivity for conservation.
基金supported by National Natural Science Foundation of China(No.32000355 and No.32370561)Research start-up funds of Anhui Normal University(No.751865)Anhui Forestry Science and Technology Innovation Project(AHLYCX-2021-01).
文摘Genetic factors play a key role in determination of the structure of the cloacal flora for newborn Chinese Alligators.We collected the cloacal microbiomes for 24 newborn Chinese Alligators from three different genetic backgrounds for 16S gene amplicon sequencing.The number of cloacal flora for the Chinese Alligators from different groups was comparable but differed structurally.There were variations in proportions of floral compositions at the phylum and family levels;however,the main difference was at the genus level.There were two significant differences in richness and evenness among the three groups.Non-metric multidimensional scaling NMDS analysis revealed that the 24 samples could be clearly divided into three categories based on their genetic backgrounds(stress=0.0244).Thus,we postulated that newborn Chinese Alligators with different genetic backgrounds have different immune strengths,which affects individual responses to environmental microorganisms.In summary,newborn Chinese Alligators from different genetic backgrounds exhibit variations in cloacal microbiome.
基金the National Natural Science Foundation of China(No.21666016)the National Key R&D Program of China(2018YFC1900200)and the Key Laboratory and the Analysis and Testing Foundation of Kunming University of Science and Technology(2017M20162207011,2019P20183107007).
文摘The high water content of sludge has always posed significant challenges for its treatment.Synthetic flocculants,which are widely used in sewage treatment plants,can cause secondary pollution during their production and use.Thus,natural polymer flocculants made of natural materials have received increased research attention recently.Corncore,an agricultural waste,was modified through alkalization with sodium hydroxide(NaOH)and etherification with cetyltrimethylammonium bromide(CTMAB)in this study.The L16(45)orthogonal array was used to study the modification conditions.The moisture content(MC)of treated sludge was reduced by approximately 37%with the addition of modified corncore powder(MCCP),which was synthesized under optimal conditions.In addition,changes in the functional groups of the material before and after modification were determined by FTIR.Thermogravimetric analysis indicated that MCCP was steady at room temperature,moreover,BET analysis showed that MCCP had greater surface area.The microstructures of material before and after modification were examined by scanning electron microscopy,revealing that MCCP had a flakeshaped structure and had an increased area of contact area with sludge particles.MCCP is a dehydrating agent that can enhance sludge dewaterability through charge neutralization and reagglomeration and provide superior economic benefits.
基金supported by the National Natural Science Foundation of China(62231020)the Youth Innovation Team of Shaanxi Universities。
文摘The foundation of ad hoc networks lies in the guarantee of continuous connectivity.However,critical nodes,whose failure can easily destroy network connectivity,will influence the ad hoc network connectivity significantly.To protect the network efficiently,critical nodes should be identified accurately and rapidly.Unlike existing critical node identification methods for unknown topology that identify critical nodes according to historical information,this paper develops a critical node identification method to relax the prior topology information condition about critical nodes.Specifically,we first deduce a theorem about the minimum communication range for a node through the number of nodes and deployment ranges,and prove the universality of the theorem in a realistic two-dimensional scenario.After that,we analyze the relationship between communication range and degree value for each node and prove that the greater number of nodes within the communication range of a node,the greater degree value of nodes with high probability.Moreover,we develop a novel strategy to improve the accuracy of critical node identification without topology information.Finally,simulation results indicate the proposed strategy can achieve high accuracy and low redundancy while ensuring low time consumption in the scenarios with unknown topology information in ad hoc networks.
基金funded by grants from the National Natural Science Foundation of China(No.82272935 to Wengang Li.,Nos.91957120 and 21974114 to Shuhai Lin.)the Scientific Research Foundation for Advanced Talents,Xiang’an Hospital of Xiamen University(No.PM20180917008 to Wengang Li.)+3 种基金Joint laboratory of School of Medicine,Xiamen University-Shanghai Jiangxia Blood Technology Co.Ltd.(No.XDHT2020010C to Wengang Lin and Ye Shen.)the Fundamental Research Funds for the Central Universities(No.20720210001 to Shuhai Lin.)Major Science and Technology Special Project of Fujian Province(No.2022YZ036012 to Shuhai Lin)Natural Science Foundation of Fujian Province(No.2021J01123522 to Zhigang Zheng).
文摘Retroperitoneal liposarcoma(RLPS)is the main subtype of retroperitoneal soft sarcoma(RSTS)and has a poor prognosis and few treatment options,except for surgery.The proteomic and metabolic profiles of RLPS have remained unclear.The aim of our study was to reveal the metabolic profile of RLPS.Here,we performed proteomic analysis(n=10),metabolomic analysis(n=51),and lipidomic analysis(n=50)of retroperitoneal dedifferentiated liposarcoma(RDDLPS)and retroperitoneal well-differentiated liposarcoma(RWDLPS)tissue and paired adjacent adipose tissue obtained during surgery.Data analysis mainly revealed that glycolysis,purine metabolism,pyrimidine metabolism and phospholipid formation were upregulated in both RDDLPS and RWDLPS tissue compared with the adjacent adipose tissue,whereas the tricarboxylic acid(TCA)cycle,lipid absorption and synthesis,fatty acid degradation and biosynthesis,as well as glycine,serine,and threonine metabolism were downregulated.Of particular importance,the glycolytic inhibitor 2-deoxy-D-glucose and pentose phosphate pathway(PPP)inhibitor RRX-001 significantly promoted the antitumor effects of the MDM2 inhibitor RG7112 and CDK4 inhibitor abemaciclib.Our study not only describes the metabolic profiles of RDDLPS and RWDLPS,but also offers potential therapeutic targets and strategies for RLPS.
基金supported by the Joint Funds of the Ministry of Education of China(No.6141A02022383)the Fundamental Research Funds for the Central Universities of Ministry of Education of China(No.20101195611)
文摘In order to improve the sensitivity of the Compass B1C signal acquisition for the receiver,the principle of constant false alarm rate(CFAR)is applied for the B1C pilot channel acquisition to realize the dynamic adjustment of the threshold of acquisition against the carrier to noise ratio.The non-coherent data/pilot combined acquisition algorithm for B1C signal is analyzed to make full use of the power of the B1C signal under the condition of low carrier to noise ratio.On this basis,to improve the acquisition sensitivity of the receiver,the principle of constant false alarm probability is applied for the non-coherent data/pilot combined acquisition algorithm.Theoretical analysis and simulations show that the non-coherent data/pilot combined acquisition algorithm with CFAR improves the B1C signal acquisition sensitivity of the receiver significantly,and achieves a better Receiver Operating Characteristic compared with the traditional acquisition algorithms.
基金supported by the National Natural Science Foundation of China (61250005)Jiangxi Postdoctoral Science Foundation(2013KY07)
文摘A joint power control and relay selection scheme is considered for a cooperative and cognitive radio system where a secondary network shares spectrum with the primary network. In the secondary network, two secondary users (SUs) communicate with each other via an assist relay. The main point is to provide the best system performance to SUs while maintaining the interference power at primary user (PU) under a certain level. Using convex optimization, a closed-form solution is obtained when optimizing the power allocation among the two nodes and relay. Based on this result, a joint power control and relay selection scheme with fewer variable dimensions is proposed to maximize the achievable rate of the secondary system. Simulation results demonstrate that the sum rate of the cognitive two-way relay network increases compared with a random relay selection and fixed power allocation.
基金support by the National Natural Science Foundation of China (60702060)the 111 Project
文摘For reducing the inter-user interference in multi-user multiple-input multiple-output(MU-MIMO) wireless communication systems,e.g.,MIMO-orthogonal frequency division multiplexing(MIMO-OFDM) systems,it is often desirable to the complex preprocessing at the transmitter.This paper proposes a multi-user beamforming algorithm with sub-codebook selection.Based on the minimal leakage criterion,the codebook selection,limited feed-forward and minimum mean square error(MMSE) detection are combined in the proposed algorithm.This avoids the complex channel matrix decomposition and inversion.Consequently,the computational complexity at the transmitter is significantly reduced.Simulation results show that the proposed algorithm performs better than existing beamforming algorithms.
基金supported by grants from the National Natural Science Foundation of China(No.81972223 to Wengang Li,No.81970485 to Chundong Yu)the Scientific Research Foundation for Advanced Talents,Xiang’an Hospital of Xiamen University(No.PM20180917008 to Wengang Li)the Natural Science Foundation of Fujian province(No.2018J01366 to Liyong Huang).
文摘Dear Editor,Soft tissue sarcomas are a heterogeneous group of rare malignancies with mesenchymal origin that can arise at any anatomic site.They account for almost 1.5% of all malignancies in humans,with an increased incidence in young adults[1,2].The retroperitoneum is the primary site of 15%-20% of soft tissue sarcomas[3,4].