[Objectives]This study was conducted to investigate the pharmacokinetic characteristics of arctigenin from water extract of Fructus Arctii in piglets,understand its absorption,distribution,transformation and excretion...[Objectives]This study was conducted to investigate the pharmacokinetic characteristics of arctigenin from water extract of Fructus Arctii in piglets,understand its absorption,distribution,transformation and excretion in piglets,and provide theoretical reference for the development and clinical use of new veterinary drugs.[Methods]Six healthy piglets,weighing(30.0±5.0)kg,were selected and administered by gavage with a Fructus Arctii water extract at 1.0 g/kg·bw.Blood was collected from the anterior vena cava at different time points.The concentration of arctigenin in pig plasma was determined by HPLC.The main pharmacokinetic parameters were:absorption half-life(t1/2 ka)(0.098±0.006)h,distribution half-life(t1/2α)(0.208±0.009)h,elimination half-life(t1/2β)(23.816±2.151)h,apparent volume of distribution(Vd)(32.212±4.033)L/kg,apparent volume of distribution(Vd)(32.212±4.033)L/kg,clearance(CLb)(2.384±1.589)L/(h·kg),peak time(tmax)(0.251±0.011)h,peak concentration(Cmax)(0.560±0.063)μg/ml,and the area under the curve(AUC)at the time of drug administration(9.620±0.752)μg·h/ml.[Results]After oral administration of the water extract powder of Fructus Arctii,arctigenin showed a two-compartment model with absorption in piglets,with the characteristics of fast absorption,wide distribution and slow elimination.Arctigenin might have a hepatoenteral circulation in piglets,and the drug effect could last for a long time.[Conclusions]This study provides a theoretical basis and reference for the development and clinical use of new veterinary drugs.展开更多
Dear Editor,In early 2013,the first case of a human infection with avian influenza A(H7N9)virus was reported in the Yangtze River Delta region of China(Liu et al.2013).Since early2013,a total of 1533 laboratory-confir...Dear Editor,In early 2013,the first case of a human infection with avian influenza A(H7N9)virus was reported in the Yangtze River Delta region of China(Liu et al.2013).Since early2013,a total of 1533 laboratory-confirmed human infections with avian H7N9 viruses have been reported to展开更多
Recent advances in battery energy storage technologies enable increasing number of photovoltaic-battery energy storage systems(PV-BESS)to be deployed and connected with current power grids.The reliable and efficient u...Recent advances in battery energy storage technologies enable increasing number of photovoltaic-battery energy storage systems(PV-BESS)to be deployed and connected with current power grids.The reliable and efficient utilization of BESS imposes an obvious technical challenge which needs to be urgently addressed.In this paper,the optimal operation of PV-BESS based power plant is investigated.The operational scenarios are firstly partitioned using a self-organizing map(SOM)clustering based approach.The revenue optimization model is adopted for the PV-BESS power plants to determine the optimal operational modes under typical conditions for a set of considerations,e.g.power generation revenue,assessing rewards/penalties as well as peak shaving/valley filling revenue.The solution is evaluated through a set of case studies,and the numerical result demonstrates the effectiveness of the suggested solution can optimally operate the BESS with the maximal revenue.展开更多
基金Hubei Provincial Technical Innovation Major Project(2019AEE006)Wuhan Animal and Poultry Chinese Herbal Medicine Development Engineering Technology Research Center(2014021511020460)Hubei Provincial Central Government Guiding Local Science and Technology Development Fundation of China(2020ZYYD029)。
文摘[Objectives]This study was conducted to investigate the pharmacokinetic characteristics of arctigenin from water extract of Fructus Arctii in piglets,understand its absorption,distribution,transformation and excretion in piglets,and provide theoretical reference for the development and clinical use of new veterinary drugs.[Methods]Six healthy piglets,weighing(30.0±5.0)kg,were selected and administered by gavage with a Fructus Arctii water extract at 1.0 g/kg·bw.Blood was collected from the anterior vena cava at different time points.The concentration of arctigenin in pig plasma was determined by HPLC.The main pharmacokinetic parameters were:absorption half-life(t1/2 ka)(0.098±0.006)h,distribution half-life(t1/2α)(0.208±0.009)h,elimination half-life(t1/2β)(23.816±2.151)h,apparent volume of distribution(Vd)(32.212±4.033)L/kg,apparent volume of distribution(Vd)(32.212±4.033)L/kg,clearance(CLb)(2.384±1.589)L/(h·kg),peak time(tmax)(0.251±0.011)h,peak concentration(Cmax)(0.560±0.063)μg/ml,and the area under the curve(AUC)at the time of drug administration(9.620±0.752)μg·h/ml.[Results]After oral administration of the water extract powder of Fructus Arctii,arctigenin showed a two-compartment model with absorption in piglets,with the characteristics of fast absorption,wide distribution and slow elimination.Arctigenin might have a hepatoenteral circulation in piglets,and the drug effect could last for a long time.[Conclusions]This study provides a theoretical basis and reference for the development and clinical use of new veterinary drugs.
基金supported by grants from the National Natural Science Foundation of China (31400787,31570026)Hubei Provincial Natural Science Foundation of China (2016CFC743)+1 种基金Wuhan Youth Science and technology plan (2016070204010104)Special Project of Ministry of Science and Technology (2013FY113500)
文摘Dear Editor,In early 2013,the first case of a human infection with avian influenza A(H7N9)virus was reported in the Yangtze River Delta region of China(Liu et al.2013).Since early2013,a total of 1533 laboratory-confirmed human infections with avian H7N9 viruses have been reported to
文摘Recent advances in battery energy storage technologies enable increasing number of photovoltaic-battery energy storage systems(PV-BESS)to be deployed and connected with current power grids.The reliable and efficient utilization of BESS imposes an obvious technical challenge which needs to be urgently addressed.In this paper,the optimal operation of PV-BESS based power plant is investigated.The operational scenarios are firstly partitioned using a self-organizing map(SOM)clustering based approach.The revenue optimization model is adopted for the PV-BESS power plants to determine the optimal operational modes under typical conditions for a set of considerations,e.g.power generation revenue,assessing rewards/penalties as well as peak shaving/valley filling revenue.The solution is evaluated through a set of case studies,and the numerical result demonstrates the effectiveness of the suggested solution can optimally operate the BESS with the maximal revenue.
