Multiple sequence alignment （MSA） is the alignment among more than two molecular biological sequences, which is a fundamental method to analyze evolutionary events such as mutations, insertions, deletions, and re-ar...Multiple sequence alignment （MSA） is the alignment among more than two molecular biological sequences, which is a fundamental method to analyze evolutionary events such as mutations, insertions, deletions, and re-arrangements. In theory, a dynamic programming algorithm can be employed to produce the optimal MSA. However, this leads to an explosive increase in computing time and memory consumption as the number of sequences increases （Taylor, 1990）. So far, MSA is still regarded as one of the most challenging problems in bioinformatics and computational biology （Chatzou et al., 2016）.展开更多
基金supported by the National Key R&D Program of China (Nos. 2017YFB0202600, 2016YFC1302500, 2016YFB0200400 and 2017YFB0202104)the National Natural Science Foundation of China (Nos. 61772543, U1435222, 61625202, 61272056 and 61771331)Guangdong Provincial Department of Science and Technology (No. 2016B090918122)
文摘Multiple sequence alignment （MSA） is the alignment among more than two molecular biological sequences, which is a fundamental method to analyze evolutionary events such as mutations, insertions, deletions, and re-arrangements. In theory, a dynamic programming algorithm can be employed to produce the optimal MSA. However, this leads to an explosive increase in computing time and memory consumption as the number of sequences increases （Taylor, 1990）. So far, MSA is still regarded as one of the most challenging problems in bioinformatics and computational biology （Chatzou et al., 2016）.
