Objective:Surgical resection remains the mainstream radical therapy in patients with breast cancer.Given that no consensus has been reached on the exact indication for levelⅢlymph node dissection,the aim of this stud...Objective:Surgical resection remains the mainstream radical therapy in patients with breast cancer.Given that no consensus has been reached on the exact indication for levelⅢlymph node dissection,the aim of this study is to explore factors associated with levelⅢlymph nodes positive and survival analysis of its dissection in patients with breast cancer.Materials and methods:A retrospective study including 61 patients after levelⅠ-Ⅲdissection via a smaller incision of pectoralis major and 61 patients experiencing only levelⅠandⅡclearance was performed.Clinicopathological outcomes were compared initially and survival analysis was conducted subsequently.Results:No significant differences were presented in baseline and clinicopathological characteristics between the two groups.Ten(16.4%)patients’levelⅢnodes were proven positive after levelⅢdissection.Positive nodes in levelⅠandⅡlymph nodes over 9 was demonstrated as an independent predictor of levelⅢnodes positive(OR:200.75[95%CI:7.77e5187.19],p-0.001).Although the levelⅠ-Ⅲlymph node dissection group presented a seemingly better disease-free survival,statistical significance was not detected(p-0.21).Conclusions:This study revealed that having positive nodes in levelⅠandⅡlymph nodes over 9 was a risk factor of levelⅢlymph nodes positive.But levelⅢlymph node dissection does not offer definite survival benefit.展开更多
基金The studywas supported by Scientific Research Project of Health and Family Planning Commission of Zhejiang Province,China(2017ZD022)Scientific Research Project of Educational Commission of Zhejiang Province,China(Y201737977)Zhejiang Provincial Natural Science Foundation of China(LQ19H160034).
文摘Objective:Surgical resection remains the mainstream radical therapy in patients with breast cancer.Given that no consensus has been reached on the exact indication for levelⅢlymph node dissection,the aim of this study is to explore factors associated with levelⅢlymph nodes positive and survival analysis of its dissection in patients with breast cancer.Materials and methods:A retrospective study including 61 patients after levelⅠ-Ⅲdissection via a smaller incision of pectoralis major and 61 patients experiencing only levelⅠandⅡclearance was performed.Clinicopathological outcomes were compared initially and survival analysis was conducted subsequently.Results:No significant differences were presented in baseline and clinicopathological characteristics between the two groups.Ten(16.4%)patients’levelⅢnodes were proven positive after levelⅢdissection.Positive nodes in levelⅠandⅡlymph nodes over 9 was demonstrated as an independent predictor of levelⅢnodes positive(OR:200.75[95%CI:7.77e5187.19],p-0.001).Although the levelⅠ-Ⅲlymph node dissection group presented a seemingly better disease-free survival,statistical significance was not detected(p-0.21).Conclusions:This study revealed that having positive nodes in levelⅠandⅡlymph nodes over 9 was a risk factor of levelⅢlymph nodes positive.But levelⅢlymph node dissection does not offer definite survival benefit.
