在胶质瘤治疗中应用“组合拳式”策略的研究

胶质瘤(glioblastoma,GBM)起源于神经胶质细胞,尽可能完全手术切除后辅以放疗和化疗是当前的标准治疗方式。GBM在放化疗后不仅会加速细胞的死亡过程,还伴随着细胞衰老(cellular senescence)。衰老细胞会产生衰老相关的分泌表型(senescence-associated seretory phenotype,SASP),对肿瘤微环境产生双重影响。“组合拳式(one-two punch)”策略通过诱导肿瘤细胞衰老后特异性清除衰老细胞、抑制SASP分泌,这为肿瘤治疗提供了一个新的方向。本文就肿瘤衰老细胞和SASP的产生机制、抗衰老药物清除衰老细胞,以及目前采取“组合拳式”策略治疗GBM的情况进行综述。

TaNRT2.1-6B is a dual-affinity nitrate transporter contributing to nitrogen uptake in bread wheat under both nitrogen deficiency and sufficiency

Multiple nitrate transporter(NRT)genes exist in the genome of bread wheat,and it is of great importance to identify the elite NRT genes for N-efficient wheat cultivar breeding.A candidate gene association study(CGAS)of six N use efficiency(NUE)related traits(grain N concentration(GNC),straw N concentration(SNC),grain yield(GY),grain N accumulation(GNA),shoot total N accumulation(STN)and N harvest index(NHI))was performed based on SNPs in 46 NRT2 genes using a panel composed of 286 wheat cultivars.CGAS identified TaNRT2.1-6B as an elite NRT gene that is significantly associated with four(NHI,SNC,GNA and GY)of the six NUE-related traits simultaneously.TaNRT2.1-6B is located on the plasma membrane and acts as a dual-affinity NRT.The overexpression of TaNRT2.1-6B increased the N influx and root growth of wheat,whereas gene silence lines resulted in the opposite effects.The overexpression of TaNRT2.1-6B also improved GY and N accumulation of wheat under either limited or sufficient N conditions.The data provide the TaNRT2.1-6B gene and the two associated SNP markers as promising powerful tools for breeding wheat cultivars with high N uptake ability and NUE.

青海省公路工程建设品质提升实现路径探讨

随着品质工程理念在公路建设中的落地生根和不断发展,全国公路建设行业的工作重点也开始发生了转变,从最初提出围绕七大方面的建设内涵,到注重专项攻关和重点突破的短板消除,再到近期追求高质量目标这一趋势来看,品质工程正经历着螺旋上升式的“转型升级”。本文将结合品质工程最新发展趋势和青海省公路工程建设发展现状,探索青海省公路建设的品质提升实现路径,初步提出打造工业化建造示范、提高工程耐久性、推进智慧工地应用、强化施工安全管控以及促进“交通+旅游”融合等策略,为青海省交通强省、质量强省的早日实现提供一定参考和借鉴。