Olive leaves have an antioxidant capacity, and olive leaf extract can protect the blood, spleen and hippocampus in lead-poisoned mice. However, little is known about the effects of olive leaf extract on lead-induced b...Olive leaves have an antioxidant capacity, and olive leaf extract can protect the blood, spleen and hippocampus in lead-poisoned mice. However, little is known about the effects of olive leaf extract on lead-induced brain injury. This study was designed to determine whether olive leaf extract can inhibit lead-induced brain injury, and whether this effect is associated with antioxidant capacity. First, we established a mouse model of lead poisoning by continuous intragastric administration of lead acetate for 30 days. Two hours after successful model establishment, lead-poisoned mice were given olive leaf extract at doses of 250, 500 or 1 000 mg/kg daily by intragastric administration for 50 days. Under the transmission electron microscope, olive leaf extract attenuated neuronal and capillary injury and reduced damage to organelles and the matrix around the capillaries in the frontal lobe of the cerebral cortex in the lead-poisoned mice. Olive leaf extract at a dose of 1 000 mg/kg had the greatest protective effect. Spectrophotometry showed that olive leaf extract significantly in- creased the activities of superoxide dismutase, catalase, alkaline phosphatase and acid phes- phatase, while it reduced malondialdehyde content, in a dose-dependent manner. Furthermore, immunohistochemical staining revealed that olive leaf extract dose-dependently decreased Bax protein expression in the cerebral cortex of lead-poisoned mice. Our findings indicate that olive leaf extract can inhibit lead-induced brain injury by increasing antioxidant capacity and reducing apop- tosis.展开更多
Water footprint(WF)measures human appropriation of water resources for consumptive use of surface and ground water(blue WF)and soil water(green WF)and for assimilating polluted water(grey WF).Questions have been often...Water footprint(WF)measures human appropriation of water resources for consumptive use of surface and ground water(blue WF)and soil water(green WF)and for assimilating polluted water(grey WF).Questions have been often asked about the exact meaning behind the numbers from WF accounting.However,to date environmental sustainability of WF has never been assessed at the sub-national level over time.This study evaluated the environmental sustainability of blue,green and grey WF for China’s 31 mainland provinces in 2002,2007 and 2012,and identified the unsustainable hotspots.Overall,the total WF increased by 30%between 2002 and 2012.The growth can be attributed to the increase of grey WF because the green and blue WF showed only a slight rise.Among all provinces investigated in 2012,eleven showed unsustainable blue WF(sustainability index SI<0),which were mainly located in the North China Plain.There were 12 provinces that displayed unsustainable green WF,and they were distributed in China’s southern and southeastern areas.The grey WF was not sustainable in approximately two third of provinces(19),which were mainly located in China’s middle and northern regions and Guangdong province.More than half of China’s provinces showed trends of improved SI of green and blue WF from 2002 to 2012.However,the SI of grey WF decreased in almost two third of provinces.Poor levels of WF sustainability were due to water scarcity and pollution,which intensify the degradation of local rivers and ecosystems and make restoration more difficult.The results shed light on the policy making needed to improve sustainable water management,and ecological restoration of hotspot regions.展开更多
With the advent of the information age,all walks of life have paid more and more attention to the development and application of digital technology.At the same time,the construction industry,which is a traditionally i...With the advent of the information age,all walks of life have paid more and more attention to the development and application of digital technology.At the same time,the construction industry,which is a traditionally important industry,is not an exception.A series of high-tech digital technologies have been widely used in architectural design and construction,such as BIM technology,3D printing technology,and VR technology.In view of the teaching link of architectural talent training,it is necessary to keep up with the development trend of the digital age,integrate these three kinds of technology into architectural teaching,and impart knowledge to students from planar 2D textbooks to 3D visual digital models,and further transform it from 3D digital to physical perceive or virtual simulation level,and reform teaching methods in all dimensions and in all dimensions to improve teaching effect.In this paper,the feasibility and necessity of integration of the above three architectural digital techniques into the teaching process of"building construction"from the aspects of teaching content,teaching method and teaching evaluation were discussed,and a new teaching model under the background of digital technology was proposed,which has certain teaching reference significance.展开更多
基金supported by the Natural Science Foundation of Gansu Province,No.1107RJZK243a grant from Gansu Provincial Education Committee,No.1128B-01
文摘Olive leaves have an antioxidant capacity, and olive leaf extract can protect the blood, spleen and hippocampus in lead-poisoned mice. However, little is known about the effects of olive leaf extract on lead-induced brain injury. This study was designed to determine whether olive leaf extract can inhibit lead-induced brain injury, and whether this effect is associated with antioxidant capacity. First, we established a mouse model of lead poisoning by continuous intragastric administration of lead acetate for 30 days. Two hours after successful model establishment, lead-poisoned mice were given olive leaf extract at doses of 250, 500 or 1 000 mg/kg daily by intragastric administration for 50 days. Under the transmission electron microscope, olive leaf extract attenuated neuronal and capillary injury and reduced damage to organelles and the matrix around the capillaries in the frontal lobe of the cerebral cortex in the lead-poisoned mice. Olive leaf extract at a dose of 1 000 mg/kg had the greatest protective effect. Spectrophotometry showed that olive leaf extract significantly in- creased the activities of superoxide dismutase, catalase, alkaline phosphatase and acid phes- phatase, while it reduced malondialdehyde content, in a dose-dependent manner. Furthermore, immunohistochemical staining revealed that olive leaf extract dose-dependently decreased Bax protein expression in the cerebral cortex of lead-poisoned mice. Our findings indicate that olive leaf extract can inhibit lead-induced brain injury by increasing antioxidant capacity and reducing apop- tosis.
基金supported by the National Natural Science Foundation of China(Grant No.41625001)the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDA20060402)+4 种基金the Pengcheng Scholar Program of Shenzhen,the National High-level Talents Special Support Plan(“Ten Thousand Talents Plan”)the Leading Innovative Talent Program for young and middle-aged scholars by the Ministry of Science and Technologysupported by the Guangdong Provincial Key Laboratory of Soil and Groundwater Pollution Control(Grant No.2017B030301012)the State Environmental Protection Key Laboratory of Integrated Surface Water-Groundwater Pollution Controlthe High-level Special Funding of the Southern University of Science and Technology(Grant No.G02296302,G02296402).
文摘Water footprint(WF)measures human appropriation of water resources for consumptive use of surface and ground water(blue WF)and soil water(green WF)and for assimilating polluted water(grey WF).Questions have been often asked about the exact meaning behind the numbers from WF accounting.However,to date environmental sustainability of WF has never been assessed at the sub-national level over time.This study evaluated the environmental sustainability of blue,green and grey WF for China’s 31 mainland provinces in 2002,2007 and 2012,and identified the unsustainable hotspots.Overall,the total WF increased by 30%between 2002 and 2012.The growth can be attributed to the increase of grey WF because the green and blue WF showed only a slight rise.Among all provinces investigated in 2012,eleven showed unsustainable blue WF(sustainability index SI<0),which were mainly located in the North China Plain.There were 12 provinces that displayed unsustainable green WF,and they were distributed in China’s southern and southeastern areas.The grey WF was not sustainable in approximately two third of provinces(19),which were mainly located in China’s middle and northern regions and Guangdong province.More than half of China’s provinces showed trends of improved SI of green and blue WF from 2002 to 2012.However,the SI of grey WF decreased in almost two third of provinces.Poor levels of WF sustainability were due to water scarcity and pollution,which intensify the degradation of local rivers and ecosystems and make restoration more difficult.The results shed light on the policy making needed to improve sustainable water management,and ecological restoration of hotspot regions.
基金Supported by the Teaching Reform Project of Jiangxi Normal University(Exploration and Research on the Practical Teaching Reform of Building Construction Course)
文摘With the advent of the information age,all walks of life have paid more and more attention to the development and application of digital technology.At the same time,the construction industry,which is a traditionally important industry,is not an exception.A series of high-tech digital technologies have been widely used in architectural design and construction,such as BIM technology,3D printing technology,and VR technology.In view of the teaching link of architectural talent training,it is necessary to keep up with the development trend of the digital age,integrate these three kinds of technology into architectural teaching,and impart knowledge to students from planar 2D textbooks to 3D visual digital models,and further transform it from 3D digital to physical perceive or virtual simulation level,and reform teaching methods in all dimensions and in all dimensions to improve teaching effect.In this paper,the feasibility and necessity of integration of the above three architectural digital techniques into the teaching process of"building construction"from the aspects of teaching content,teaching method and teaching evaluation were discussed,and a new teaching model under the background of digital technology was proposed,which has certain teaching reference significance.
