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HER2阳性非小细胞肺癌诊断及治疗进展
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作者 任晨怡 曹赫 +2 位作者 郑静 孙文佳 周建娅 《中国肺癌杂志》 CAS CSCD 北大核心 2023年第4期291-302,共12页
肺癌是全球最常见的恶性肿瘤,也是癌症死亡的主要原因。人表皮生长因子受体2(human epidermal growth factor receptor 2,HER2)阳性非小细胞肺癌(non-small cell lung cancer,NSCLC)是指因HER2基因发生突变、扩增、过表达,导致其功能失... 肺癌是全球最常见的恶性肿瘤,也是癌症死亡的主要原因。人表皮生长因子受体2(human epidermal growth factor receptor 2,HER2)阳性非小细胞肺癌(non-small cell lung cancer,NSCLC)是指因HER2基因发生突变、扩增、过表达,导致其功能失调,从而发生的NSCLC。HER2是HER家族中活性最高的受体,可以与其他成员结合形成二聚体,激活多种信号通路,从而调节细胞增殖、分化、迁移和凋亡。在NSCLC中,HER2阳性通常被认为是预后不良的标志。目前HER2阳性NSCLC的诊疗尚未成熟。通常使用免疫组化(immunohistochemistry,IHC)、下一代测序(next generation sequencing,NGS)等方法来检测HER2突变、扩增、过表达这些阳性状态。在先前的研究中,抗肿瘤药物在HER2阳性NSCLC中并未显示出理想的疗效。但近些年来,相关研究表明靶向治疗中的抗体药物偶联物(antibody-drug conjugates,ADCs)和新型酪氨酸激酶抑制剂(tyrosine kinase inhibitors,TKIs)对HER2阳性NSCLC显示出较好的抗肿瘤活性。本文归纳了HER2阳性NSCLC的诊断和治疗进展,为后续研究提供参考。 展开更多
关键词 肺肿瘤 人表皮生长因子受体2 靶向治疗
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Review of intelligent diagnosis methods for imaging gland cancer based on machine learning
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作者 Han JIANG wenjia sun +3 位作者 Hanfei GUO Jiayuan ZENG Xin XUE Shuai LI 《Virtual Reality & Intelligent Hardware》 EI 2023年第4期293-316,共24页
Gland cancer is a high-incidence disease that endangers human health,and its early detection and treatment require efficient,accurate,and objective intelligent diagnosis methods.In recent years,the advent of machine l... Gland cancer is a high-incidence disease that endangers human health,and its early detection and treatment require efficient,accurate,and objective intelligent diagnosis methods.In recent years,the advent of machine learning techniques has yielded satisfactory results in intelligent gland cancer diagnosis based on clinical images,significantly improving the accuracy and efficiency of medical image interpretation while reducing the workload of doctors.The focus of this study is to review,classify,and analyze intelligent diagnosis methods for imaging gland cancer based on machine learning and deep learning.This paper briefly introduces some basic imaging principles of multimodal medical images,such as the commonly used computed tomography(CT),magnetic resonance imaging(MRI),ultrasound(US),positron emission tomography(PET),and pathology.In addition,the intelligent diagnosis methods for imaging gland cancer were further classified into supervised learning and weakly supervised learning.Supervised learning consists of traditional machine learning methods,such as K-nearest neighbor algorithm(KNN),support vector machine(SVM),and multilayer perceptron,and deep learning methods evolving from convolutional neural network(CNN).By contrast,weakly supervised learning can be further categorized into active learning,semisupervised learning,and transfer learning.State-of-the-art methods are illustrated with implementation details,including image segmentation,feature extraction,and optimization of classifiers.Their performances are evaluated through indicators,such as accuracy,precision,and sensitivity.In conclusion,the challenges and development trends of intelligent diagnosis methods for imaging gland cancer were addressed and discussed. 展开更多
关键词 Gland cancer Intelligent diagnosis Machine learning Deep learning Multimodal medical images
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Study on a Comprehensive Energy-Saving Sail by CFD Method
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作者 Yanna Zheng Dexing Liu +2 位作者 Hongwei An wenjia sun Tiaojian Xu 《Open Journal of Fluid Dynamics》 2016年第3期145-155,共11页
A comprehensive energy-saving sail (CES) has been proposed in order to promote energy saving and emission reduction from shipping. Wind energy is harvested for propulsion and electrical generator at the same time by a... A comprehensive energy-saving sail (CES) has been proposed in order to promote energy saving and emission reduction from shipping. Wind energy is harvested for propulsion and electrical generator at the same time by a unique structure of CES. A CFD (Computational Fluid Dynamics) code is verified by a case of arc wind sail, and it is used to simulate the pressure and velocity around the CES. The results show that the outlet velocity of air tunnel V<sub>o</sub> and wind velocity V<sub>i</sub> serve as an equation V<sub>o</sub> ≈ 1.31V<sub>i</sub>, which means the CES can effectively improve the conversion efficiency. In addition, it is found that V<sub>o</sub> increases with the tunnel diameter to some extend over which it will keep almost constant. 展开更多
关键词 Energy-Saving Sail Wind Power Generation Wind-Assisted Propulsion
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多色标记免疫组织化学染色和免疫荧光染色在肺癌免疫治疗中的研究进展 被引量:2
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作者 孙文佳 周建娅 周建英 《中国肺癌杂志》 CAS CSCD 北大核心 2021年第1期36-42,共7页
肺癌是目前临床上最常见的恶性肿瘤,严重威胁着患者的生命健康及生活质量。程序性细胞死亡受体1(programmed cell death receptor 1, PD-1)及其配体(programmed cell death ligand 1, PD-L1)抑制剂为非小细胞肺癌(non-small cell lung c... 肺癌是目前临床上最常见的恶性肿瘤,严重威胁着患者的生命健康及生活质量。程序性细胞死亡受体1(programmed cell death receptor 1, PD-1)及其配体(programmed cell death ligand 1, PD-L1)抑制剂为非小细胞肺癌(non-small cell lung cancer, NSCLC)患者提供了新的治疗策略。现有的生物标志物检测对准确选择免疫治疗受益的患者均有一定的价值,但都存在着局限性。多标记免疫组织化学/免疫荧光(multiplex immunohistochemistry/immunofluorescence,mIHC/IF)技术允许在单一组织切片上同时检测多个抗体,并对细胞组成、细胞功能和细胞-细胞相互作用进行全面研究。国内外已有大量研究使用mIHC/IF技术对肿瘤免疫微环境(tumor immune microenvironment, TIME)下特异性免疫细胞群进行了探索,发现其有助于肺癌患者临床预后判断及疗效预测。肺癌免疫治疗时代,这项技术在转化研究和临床实践中均具有良好的应用前景。本文就mIHC/IF检测方法在肺癌免疫治疗中的研究进展进行了总结和展望。 展开更多
关键词 肺肿瘤 多色标记 免疫组织化学 免疫荧光 免疫治疗
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On "China-measures related to the exportation of various raw materials" case in terms of DSB's interpretations 被引量:1
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作者 Hua Shi wenjia sun Scott Albert Charles Roker 《Chinese Journal of Population,Resources and Environment》 2014年第2期165-170,共6页
The Appellate Body report in January 2012 had supported the decision of Panel in the"China-measures related to the exportation of various raw materials"case(WT/DS394,395,398)and affirmed that China's res... The Appellate Body report in January 2012 had supported the decision of Panel in the"China-measures related to the exportation of various raw materials"case(WT/DS394,395,398)and affirmed that China's restrictions(such as tariffs and quota measures)on the exportation of raw materials violated rules put forth by the WTO,which were required to be modified.In this case China's right to invoke Article 20 of GATT1994("general exception")to justify its exemption from the guidelines in Article 11.3 of the WTO Accession Protocol was denied by the Panel and the Appellate Body.This was due to the fact that the phrasing in Article 11.3 of Protocol failed to mention"GATT."This was the consequence of the two interpretation approaches the Dispute Settlement Body(DSB)adopted-a narrow textual interpretation and a subjective presumption of"legislative silence."The inappropriate use of the two methods of interpretation lead to an imbalance between the right and obligation of China under the additional obligations that were imposed upon China by the WTO,which create a negative impact on China's rare earth case and the protection of domestic natural resources. 展开更多
关键词 raw material TEXTUAL interpretation LEGISLATIVE si
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利用连续旋转旋进电子衍射断层扫描确定纳米晶的确切结构
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作者 沈弈寒 孙文甲 +2 位作者 刘扬 周钲洋 孙俊良 《Science China Materials》 SCIE EI CAS CSCD 2022年第5期1417-1420,共4页
三维电子衍射已逐渐成为人们探索微观世界的强有力的工具.本文中,我们展示了一种新的三维电子衍射数据收集方法,命名为连续旋转旋进电子衍射断层扫描(cPEDT),该方法是旋进电子衍射断层扫描(PEDT)与连续旋转电子衍射(cRED)的结合.使用cP... 三维电子衍射已逐渐成为人们探索微观世界的强有力的工具.本文中,我们展示了一种新的三维电子衍射数据收集方法,命名为连续旋转旋进电子衍射断层扫描(cPEDT),该方法是旋进电子衍射断层扫描(PEDT)与连续旋转电子衍射(cRED)的结合.使用cPEDT方法,可以避免PEDT方法中步进式过程引入的不必要的电子剂量,同时利用cPEDT收集到的数据也可以进行动力学精修从而确定材料的精确结构.该方法可以促进三维电子衍射在一些电子束敏感材料上的应用,如金属-有机框架(MOF)、共价有机框架(COF),以及一些有机物. 展开更多
关键词 电子衍射 连续旋转 断层扫描 数据收集方法 步进式 纳米晶 微观世界 PEDT
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