Clean production of Fe-based amorphous soft magnetic alloys via smelting reduction of high-phosphorus iron ore and apatite

Separated preparation of prealloys and amorphous alloys results in severe solidification-remelting and beneficial element removal-readdition contradictions,which markedly increase energy consumption and emissions.This study offered a novel strategy for the direct production of FePC amorphous soft magnetic alloys via smelting reduction of high-phosphorus iron ore(HPIO)and apatite.First,the thermodynamic conditions and equilibrium states of the carbothermal reduction reactions in HPIO were calculated,and the element content in reduced alloys was theoretically determined.The phase and structural evolutions,as well as element migration and enrichment behaviors during the smelting reduction of HPIO and Ca_(3)(PO_(4))_(2),were then experimentally verified.The addition of Ca_(3)(PO_(4))_(2)in HPIO contributes to the enrichment of the P element in reduced alloys and the subsequent development of Fe_(3)P and Fe_(2)P phases.The content of P and C elements in the range of 1.52 wt% -14.63 wt% and 0.62 wt% -2.47 wt%,respectively,can be well tailored by adding 0-50 g Ca_(3)(PO_(4))_(2)and controlling the C/O mole ratio of 0.8-1.1,which is highly consistent with the calculated results.These FePC alloys were then successfully formed into amorphous ribbons and rods.The energy consumption of the proposed strategy was estimated to be 2.00×10^(8) kJ/t,which is reduced by 30% when compared with the conventional production process.These results are critical for the comprehensive utilization of mineral resources and pave the way for the clean production of Fe-based amorphous soft magnetic alloys.

“一带一路”倡议下广东省国际贸易与国际物流协同发展研究

随着“一带一路”倡议的提出,广东省借助其开放程度高、经济实力强、辐射带动作用大的优势,加快推进广东省与“一带一路”沿线国家之间的交流与合作,其国际贸易和国际物流的发展迎来了机遇的同时,也迎来了新的挑战。查找最新相关数据,运用定量分析方法深入分析“一带一路”倡议下广东省国际贸易与国际物流协同发展的现状,发现两者可以实现协同发展,与此同时存在协同难度大、物流企业发展缓慢、两者沟通不足、存在安全隐患等问题。针对以上问题,本文从“一带一路”视角出发,提出了创造协同发展新环境、增强物流企业实力、促进两者的全面对接等建议。

Empirical Analysis on Factors Influencing Distribution of Vegetal Production

Since the reform and opening-up,there has been a great change in spatial pattern of China's vegetable production. This paper studied vegetable production in provinces of China in 1978- 2013. From the sequential characteristics,China's vegetable production area is constantly growing and takes on stage characteristic. From the spatial distribution,China's vegetable production takes on the trend of " going down the south" and " marching the west". In order to grasp rules of changes of vegetable production and the influence factors,this paper made theoretical and empirical analysis on factors possibly influencing distribution of vegetable production. Results show that major factors influencing distribution of China's vegetable production include irrigation condition,non-agricultural employment,market demand,knowledge spillover,comparative effectiveness,rural road and government policies.

Dronedarone inhibits the proliferation of esophageal squamous cell carcinoma through the CDK4/CDK6-RB1 axis in vitro and in vivo

Treatment options for patients with esophageal squamous cell carcinoma(ESCC)often result in poor prognosis and declining health-related quality of life.Screening FDA-approved drugs for cancer chemoprevention is a promising and cost-efficient strategy.Here,we found that dronedarone,an antiarrhythmic drug,could inhibit the proliferation of ESCC cells.Moreover,we conducted phosphorylomics analysis to investigate the mechanism of dronedarone-treated ESCC cells.Through computational docking models and pull-down assays,we demonstrated that dronedarone could directly bind to CDK4 and CDK6 kinases.We also proved that dronedarone effectively inhibited ESCC proliferation by targeting CDK4/CDK6 and blocking the G0/G1 phase through RB1 phosphorylation inhibition by in vitro kinase assays and cell cycle assays.Subsequently,we found that knocking out CDK4 and CDK6 decreased the susceptibility of ESCC cells to dronedarone.Furthermore,dronedarone suppressed the growth of ESCC in patient-derived tumor xenograft models in vivo.Thus,our study demonstrated that dronedarone could be repurposed as a CDK4/6 inhibitor for ESCC chemoprevention.

Dynamic nanomechanical characterization of cells in exosome therapy

Exosomes derived from mesenchymal stem cells(MSCs)have been confirmed to enhance cell proliferation and improve tissue repair.Exosomes release their contents into the cytoplasmic solution of the recipient cell to mediate cell expression,which is the main pathway through which exosomes exert therapeutic effects.The corresponding process of exosome internalization mainly occurs in the early stage of treatment.However,the therapeutic effect of exosomes in the early stage remains to be further studied.We report that the three-dimensional cell traction force can intuitively reflect the ability of exosomes to enhance the cytoskeleton and cell contractility of recipient cells,serving as an effective method to characterize the therapeutic effect of exosomes.Compared with traditional biochemical methods,we can visualize the early therapeutic effect of exosomes in real time without damage by quantifying the cell traction force.Through quantitative analysis of traction forces,we found that endometrial stromal cells exhibit short-term cell roundness accompanied by greater traction force during the early stage of exosome therapy.Further experiments revealed that exosomes enhance the traction force and cytoskeleton by regulating the Rac1/RhoA signaling pathway,thereby promoting cell proliferation.This work provides an effective method for rapidly quantifying the therapeutic effects of exosomes and studying the underlying mechanisms involved.

Cold-Induced Reprogramming of Subcutaneous White Adipose Tissue Assessed by Single-Cell and Single-Nucleus RNA Sequencing

Adipose browning has demonstrated therapeutic potentials in several diseases.Here,by conducting transcriptomic profiling at the single-cell and single-nucleus resolution,we reconstituted the cellular atlas in mouse inguinal subcutaneous white adipose tissue(iWAT)at thermoneutrality or chronic cold condition.All major nonimmune cells within the iWAT,including adipose stem and progenitor cells(ASPCs),mature adipocytes,endothelial cells,Schwann cells,and smooth muscle cells,were recovered,allowing us to uncover an overall and detailed blueprint for transcriptomes and intercellular cross-talks and the dynamics during white adipose tissue brown remodeling.Our findings also unravel the existence of subpopulations in mature adipocytes,ASPCs,and endothelial cells,as well as new insights on their interconversion and reprogramming in response to cold.The adipocyte subpopulation competent of major histocompatibility complex class Ⅱ(MHCⅡ)antigen presentation is potentiated.Furthermore,a subcluster of ASPC with CD74 expression was identified as the precursor of this MHCⅡ^(+)adipocyte.Beige adipocytes are transdifferented from preexisting lipid generating adipocytes,which exhibit developmental trajectory from de novo differentiation of amphiregulin cells(Aregs).Two distinct immune-like endothelial subpopulations are present in iWAT and are responsive to cold.Our data reveal fundamental changes during cold-evoked adipose browning.

Nanomechanical assay for ultrasensitive and rapid detection of SARS-CoV-2 based on peptide nucleic acid

The massive global spread of the COVID-19 pandemic makes the development of more effective and easily popularized assays critical.Here,we developed an ultrasensitive nanomechanical method based on microcantilever array and peptide nucleic acid(PNA)for the detection of severe acute respiratory syndrome-coronavirus-2(SARS-CoV-2)RNA.The method has an extremely low detection limit of 0.1 fM(105 copies/mL)for N-gene specific sequence(20 bp).Interestingly,it was further found that the detection limit of N gene(pharyngeal swab sample)was even lower,reaching 50 copies/mL.The large size of the N gene dramatically enhances the sensitivity of the nanomechanical sensor by up to three orders of magnitude.The detection limit of this amplification-free assay method is an order of magnitude lower than RT-PCR(500 copies/mL)that requires amplification.The non-specific signal in the assay is eliminated by the in-situ comparison of the array,reducing the false-positive misdiagnosis rate.The method is amplification-free and label-free,allowing for accurate diagnosis within 1 h.The strong specificity and ultrasensitivity allow single base mutations in viruses to be distinguished even at very low concentrations.Also,the method remains sensitive to fM magnitude lung cancer marker(miRNA-155).Therefore,this ultrasensitive,amplification-free and inexpensive assay is expected to be used for the early diagnosis of COVID-19 patients and to be extended as a broad detection tool.

Nanomechanical vibration profiling of oocytes

The beginning of a mammalian life commences with a fertilized oocyte.The study of oocytes is certainly one of the most intriguing scientific questions of our time.Herein,we studied oocytes from a mechanical perspective and characterized the typical life activities of oocytes by nanomechanical vibrations.During the development of oocytes from the germinal vesicle(GV)stage to the zygotes,the GV stage oocytes induced a significant nanomechanical vibration,compared with the oocytes in meiosis I(MI)and meiosis II(MII)stages and zygotes.We analyzed the characteristics of mechanical vibrations of oocytes,including the amplitude as well as the frequency.It showed that the amplitude and frequency of nanomechanical vibrations induced by oocytes were caused by the cytoskeleton(microfilaments)and the distribution of metabolic characteristics(mitochondria)within oocytes.This work provides a new perspective for clinical quality assessment and basic research of oocytes,and can open new doors for development of life science.

Repurposed benzydamine targeting CDK2 suppresses the growth of esophageal squamous cell carcinoma

Esophageal squamous cell carcinoma (ESCC) is one of the leading causes of cancer death worldwide. It is urgent to develop new drugs to improve the prognosis of ESCC patients. Here, we found benzydamine, a locally acting non-steroidal anti-inflammatory drug, had potent cytotoxic effect on ESCC cells. Benzydamine could suppress ESCC proliferation in vivo and in vitro. In terms of mechanism, CDK2 was identified as a target of benzydamine by molecular docking, pull-down assay and in vitro kinase assay. Specifically, benzydamine inhibited the growth of ESCC cells by inhibiting CDK2 activity and affecting downstream phosphorylation of MCM2, c-Myc and Rb, resulting in cell cycle arrest. Our study illustrates that benzydamine inhibits the growth of ESCC cells by downregulating the CDK2 pathway.

An early screening model of pulse detection technology for hepatic steatosis

Background The increasing prevalence of hepatic steatosis presents a considerable challenge to public health.There is a critical need for the development of novel preventive and screening strategies for this condition.Thisstudy evaluated the potential applications of wrist pulse detection technology for the early detection of liverdiseases.The pulse time-domain features of a medical exam population with and without hepatic steatosis wereassessed to develop a screening model for this disease.Methods Participants were consecutively recruited from March 2021 to March 2022 in the medical examinationcenters of the Yueyang Hospital of Integrated Traditional Chinese and Western Medicine and the Shanghai Municipal Hospital of Traditional Chinese Medicine.Clinical data from 255 participants,including general information(sex,age,and body mass index),and data related to glucose and blood lipids(fasting plasma glucose,triglyceride,total cholesterol,high-density lipoprotein,and low-density lipoprotein levels)were collected.Wrist pulse signalswere acquired using a pulse detection device,and the pulse time-domain features,including t_(1),t_(4),t_(5),T,w_(1),w_(2),h_(2)/h_(1),h_(3)/h_(1),and h5/h_(1) were extracted.Participants were assigned to hepatic steatosis and non-hepatic steatosisgroups according to their abdominal ultrasound examination results.Their clinical data and pulse time-domainfeatures were compared using chi-square and parametric or non-parametric statistical methods.Three datasetswere used to construct screening models for hepatic steatosis based on the random forest algorithm.The datasetsfor modeling were defined as Dataset 1,containing blood glucose and lipid data and general information;Dataset2,containing time-domain features and general information;Dataset 3,containing time-domain features,bloodglucose and lipid data,and general information.The evaluation metrics,accuracy,precision,recall,F1-score,andareas under the receiver operating characteristic curve(AUC)were compared for each model.Results The time-domain features of the two groups differed significantly.The t_(1),t_(4),t_(5),T,h_(2)/h_(1),h_(3)/h_(1),w_(1),and w_(2) features were higher in the hepatic steatosis group than in the non-hepatic steatosis group(P<0.05),while the h5/h_(1) features were lower in the hepatic steatosis group than in the non-hepatic steatosis group(P<0.05).The screening models for hepatic steatosis based on both time-domain features and blood glucose andlipid data outperformed those based on time-domain features or blood markers alone.The accuracy,precision,recall,F1-score,and AUC of the combined model were 81.18%,80.56%,76.32%,79%,and 87.79%,respectively.These proportions were 1.57%,1.86%,1.76%,2%,and 3.54%higher,respectively,than those of the model basedon time-domain features alone and 3.14%,4.2%,2.64%,4%,and 6.47%higher,respectively,than those of themodel based on blood glucose and lipid alone.Conclusion The early screening model for hepatic steatosis using datasets that included pulse time-domainfeatures achieved better performance.The findings suggest that pulse detection technology could be used toinform the development of a mobile medical device or remote home monitoring system to test for hepatitissteatosis.

Post-hepatoportoenterostomy Acoustic Radiation Force Impulse Elastography to Predict Two-year Outcome of Biliary Atresia

Background and Aims: Early identification of prognostic factors to predict transplant/death outcome of biliary atresia (BA) is challenging. We aimed to investigate the longitudinal changes and predictive value of dynamic changes in acoustic radiation force impulse elastography with shear wave speed (SWS) quantification and other parameters within three months after hepatoportoenterostomy (HPE) for 2-year BA outcomes. Methods: Seventy-four patients who underwent HPE between July 2016 and June 2019 were prospectively enrolled. Outcomes were classified into native liver survival and transplant/death groups. Acoustic radiation force im-pulse elastography was performed sequentially at 3 months intervals post-HPE. Cox regression analysis was used to de-termine the superior SWS values and other predictors of liver transplantation or death. Results: Among patients 2 years of age, 36 survived with a native liver, nine died, and 29 underwent liver transplantation. The trend in SWS levels in the transplant/death group was significantly different from that in the native liver survival group. ΔSWS at 1-3 months post-HPE and total bilirubin at 1 month post-HPE were se-lected as superior predictors of liver transplantation or death using multivariate Cox regression models: hazard ratio (HR)=1.927;95% confidence interval (CI): 1.475-2.661;p<0.001 and HR=1.010;95% CI: 1.003-1.017;p=0.007, respectively. The combination of the selected ΔSWS and total bilirubin had good predictive power, with an area under the receiver operating characteristics curve of 0.89, specificity 94.44% and sensitivity 73.68%. Conclusions: Our results suggest that early postoperative bilirubin levels and SWS changes were reliable predictors of 2-year BA outcomes.

Dynamic response of the cell traction force to osmotic shock

Osmotic pressure is vital to many physiological activities,such as cell proliferation,wound healing and disease treatment.However,how cells interact with the extracellular matrix(ECM)when subjected to osmotic shock remains unclear.Here,we visualize the mechanical interactions between cells and the ECM during osmotic shock by quantifying the dynamic evolution of the cell traction force.We show that both hypertonic and hypotonic shocks induce continuous and large changes in cell traction force.Moreover,the traction force varies with cell volume:the traction force increases as cells shrink and decreases as cells swell.However,the direction of the traction force is independent of cell volume changes and is always toward the center of the cell-substrate interface.Furthermore,we reveal a mechanical mechanism in which the change in cortical tension caused by osmotic shock leads to the variation in traction force,which suggests a simple method for measuring changes in cell cortical tension.These findings provide new insights into the mechanical force response of cells to the external environment and may provide a deeper understanding of how the ECM regulates cell structure and function.

濒危植物大别山五针松根际细菌群落特征与功能分析

植物根际微生物群落对植物健康生长有重要影响,每种植物根际都有其特定的微生物群落。大别山五针松(Pinus dabeshanensis)被国际自然保护联盟列为濒危物种,具有重要研究价值。该研究采用16S rRNA高通量测序技术与生物信息学方法,对濒危植物大别山五针松根际细菌群落特征与功能进行分析。结果表明,大别山五针松根际微生物的主要种类为变形菌门、放线菌门、酸杆菌门和疣微菌门。网络分析表明,大别山五针松根际细菌类群存在显著相关性,其中Bryobacter属、Bradyrhizobium属和未定义的TK10属是互作网络中的重要节点。PICRUSt1功能预测表明其微生物组功能主要为氨基酸运输和代谢、细胞壁/膜/膜生物发生以及能量产生和转换。FAPROTAX功能预测表明,大别山五针松根际富含的优势菌群具有丰富的化学异养、纤维素水解、需氧化学异养和固氮功能,其对植物生长发育具有重要作用。研究结果可为培育健康的大别山五针松根际微生物菌群及微生物资源的开发利用提供重要依据。

Single copper sites dispersed on hierarchically porous carbon for improving oxygen reduction reaction towards zinc-air battery

The demand for high-performance non-precious-metal electrocatalysts to replace the noble metal-based catalysts for oxygen reduction reaction(ORR)is intensively increasing.Herein,single-atomic copper sites supported on N-doped three-dimensional hierarchically porous carbon catalyst(Cu_(1)/NC)was prepared by coordination pyrolysis strategy.Remarkably,the Cu_(1)/NC-900 catalyst not only exhibits excellent ORR performance with a half-wave potential of 0.894 V(vs.RHE)in alkaline media,outperforming those of commercial Pt/C(0.851 V)and Cu nanoparticles anchored on N-doped porous carbon(CuNPs/NC-900),but also demonstrates high stability and methanol tolerance.Moreover,the Cu_(1)/NC-900 based Zn-air battery exhibits higher power density,rechargeability and cyclic stability than the one based on Pt/C.Both experimental and theoretical investigations demonstrated that the excellent performance of the as-obtained Cu_(1)/NC-900 could be attributed to the synergistic effect between copper coordinated by three N atoms active sites and the neighbouring carbon defect,resulting in elevated Cu d-band centers of Cu atoms and facilitating intermediate desorption for ORR process.This study may lead towards the development of highly efficient non-noble metal catalysts for applications in electrochemical energy conversion.

Enhanced orange emission by doping CeB_6 in CaAlSiN_3:Ce^(3+) phosphor for application in white LEDs

A series of CeB6-doped and CeO2-doped Ca1-xSiAlN3:xCe3+(denoted as CASN:Ce3+@CeB6 and CASN:Ce3+@CeO2, respectively) were synthesized by alloy-nitridation method under high-purity nitrogen atmosphere. The morphologies, crystal phases, and luminescence properties were investigated in detail.With an increase in the concentration of CeB6, the unit cell volume of CASN:Ce3+@CeB6slightly increases due to the substitution between ions, which leads to a change of micro structure around Ce3+. CASN:Ce3+@CeB6 efficiently emits yellow-orange light with a maximum emission intensity at around 550 nm for the content x of 0.01(being in comparable situation, CASN:Ce3+@CeO2is x = 0.04) when excited at460 nm. Compared with CASN:Ce3+@CeO2, the red emission component of Ce3+ in CASN:Ce3+@CeB6 is much stronger. This is ascribed to energy transfer of intra-Ce3+(within one Ce3+ ion) and inter-Ce3+(between Ce3+ and Ce3+ ions). In addition, the replacements of N3-(0.132 nm for CN = 4) and O2-(0.124 nm for CN = 4) by B2-(0.140 nm for CN = 4), which can lead to a marked expansion of the host lattice and a decrease of the oxidation of samples, are also responsible for the increase of red emission component. Furthermore, CASN:Ce3+@CeB6phosphor has an excellent thermal stability because of the partial substitution of Ce-O(Ce-N) bonds by more covalent Ce-B. As a result, the outstanding luminescent properties of CASN:Ce3+@CeB6 phosphor make it practical to use in the single phosphor-coated high-color-rendering power white LED.

A high-sensitivity MEMS gravimeter with a largedynamic range

Precise measurement of variations in the local gravitational acceleration is valuable for natural hazard forecasting,prospecting,and geophysical studies.Common issues of the present gravimetry technologies include their high cost,high mass,and large volume,which can potentially be solved by micro-electromechanical-system(MEMS)technology.However,the reported MEMS gravimeter does not have a high sensitivity and a large dynamic range comparable with those of the present commercial gravimeters,lowering its practicability and ruling out worldwide deployment.In this paper,we introduce a more practical MEMS gravimeter that has a higher sensitivity of 8μGal/√Hz and a larger dynamic range of 8000 mGal by using an advanced suspension design and a customized optical displacement transducer.The proposed MEMS gravimeter has performed the co-site earth tides measurement with a commercial superconducting gravimeter GWR iGrav with the results showing a correlation coefficient of 0.91.

Photodegradation-Induced Turn-On Luminescence of Tetraphenylethylene-Based Trithiocarbonate Polymers

Main observation and conclusion Fluorescent intelligent materials have attracted wide attention because of their great potential applications.One major hurdle for the development and application of fluorescent intelligent materials is the aggregation-caused quenching effect in the solid state.Herein,tetraphenylethylene-based trithiocarbonate polymers with satisfactory molecular weights(Mw up to 24900)were synthesized through a one-pot polymerization route under mild conditions.The polymers were non-emissive due to the quenching effect of the trithiocarbonate group.However,upon UV irradiation,the polymers degraded and strong emission from the tetraphenylethylene unit was observed.Such a unique property endows them with great potential applications,such as photopatterning,anti-counterfeit labels,and UV detection.

Phosphorylation inhibition of protein-tyrosine phosphatase 1B tyrosine-152 induces bone regeneration coupled with angiogenesis for bone tissue engineering

A close relationship has been reported to exist between cadherin-mediated cell-cell adhesion and integrin-mediated cell mobility,and protein tyrosine phosphatase 1B(PTP1B)may be involved in maintaining this homeostasis.The stable residence of mesenchymal stem cells(MSCs)and endothelial cells(ECs)in their niches is closely related to the regulation of PTP1B.However,the exact role of the departure of MSCs and ECs from their niches during bone regeneration is largely unknown.Here,we show that the phosphorylation state of PTP1B tyrosine-152(Y152)plays a central role in initiating the departure of these cells from their niches and their subsequent recruitment to bone defects.Based on our previous design of a PTP1B Y152 region-mimicking peptide(152RM)that significantly inhibits the phosphorylation of PTP1B Y152,further investigations revealed that 152RM enhanced cell migration partly via integrinαvβ3 and promoted MSCs osteogenic differentiation partly by inhibiting ATF3.Moreover,152RM induced type H vessels formation by activating Notch signaling.Demineralized bone matrix(DBM)scaffolds were fabricated with mesoporous silica nanoparticles(MSNs),and 152RM was then loaded onto them by electrostatic adsorption.The DBM-MSN/152RM scaffolds were demonstrated to induce bone formation and type H vessels expansion in vivo.In conclusion,our data reveal that 152RM contributes to bone formation by coupling osteogenesis with angiogenesis,which may offer a potential therapeutic strategy for bone defects.

Constructing the separation pathway for photo-generated carriers by diatomic sites decorated on MIL-53-NH2(Al)for enhanced photocatalytic performance

High yield production of phenol from hydroxylation of benzene with low energy consumption is of paramount importance,but still challenging.Herein,a new strategy,consisting of using diatomic synergistic modulation(DSM)to effectively control the separation of photo-generated carriers for an enhanced production of phenol is reported.The atomic level dispersion of Fe and Cr respectively decorated on Al based MIL-53-NH_(2)photocatalyst(Fe1/Cr:MIL-53-NH_(2))is designed,in which Cr single atoms are substituted for Al3+while Fe single atoms are coordinated by N.Notably,the Fe1/Cr:MIL-53-NH_(2)significantly boosts the photooxidation of benzene to phenol under visible light irradiation,which is much higher than those of MIL-53-NH_(2),Cr:MIL-53-NH_(2),Fe1/MIL-53-NH_(2),and Fe nanoparticles/Cr:MIL-53-NH_(2)catalysts.Theoretical and experimental results reveal that the Cr single atoms and Fe single atoms can act as electron acceptor and electron donor,respectively,during photocatalytic reaction,exhibiting a synergistic effect on the separation of the photo-generated carriers and thereby causing great enhancement on the benzene oxidation.This strategy provides new insights for rational design of advanced photocatalysts at the atomic level.

On the understanding of dielectric elastomer and its application for all-soft artificial heart

Although dielectric elastomer(DE)with substantial actuated strain(AS)has been reported 20 years ago,its scientific understanding remains unclear.The most accepted theory of DE,which is proposed in 2000,holds the view that AS of DE is induced by the Maxwell stress.According to this theory,materials have similar ratios of permittivity and Young’s modulus should have similar AS,while the experimental results are on contrary to this theory,and the experimental AS has no relationship with ideal AS.Here,a new dipole-conformation-actuated strain cross-scale model is proposed,which can be generally applied to explain the AS of DE without pre-strain.According to this model,several characteristics of an ideal DE are listed in this work and a new DE based on polyphosphazene(PPZ)is synthesized.The AS of PPZ can reach 84%without any pre-strain.At last,a PPZ-based all soft artificial heart(ASAH)is built,which works in the similar way with natural myocardium,indicating that this material has great application potential and possibility in the construction of an ASAH for heart failure(HF)patients.