The liver has remarkable capability to regenerate,employing mechanism to ensure the stable liver-to-bodyweight ratio for body homeostasis.The source of this regenerative capacity has received great attention over the ...The liver has remarkable capability to regenerate,employing mechanism to ensure the stable liver-to-bodyweight ratio for body homeostasis.The source of this regenerative capacity has received great attention over the past decade yet still remained controversial currently.Deciphering the sources for hepatocytes provides the basis for understanding tissue regeneration and repair,and also illustrates new potential therapeutic targets for treating liver diseases.In this review,we describe recent advances in genetic lineage tracing studies over liver stem cells,hepatocyte proliferation,and cell lineage conversions or cellular reprogramming.This review will also evaluate the technical strengths and limitations of methods used for studies on hepatocyte generation and cell fate plasticity in liver homeostasis,repair and regeneration.展开更多
Following publication of the original article(Pu and Zhou 2022),some errors were identified in the Back-ground and Hepatocyte proliferation sections.The updated three sentences have been highlighted in Bold typeface.
Unravelling lineage plasticity and cellular contribution to hepatocytes provides valuable information for understanding sources that fuel homeostatic renewal of the liver(Miyajima et al.,2014).In the adult stage,hepat...Unravelling lineage plasticity and cellular contribution to hepatocytes provides valuable information for understanding sources that fuel homeostatic renewal of the liver(Miyajima et al.,2014).In the adult stage,hepatocytes are mainly self-renewed through cell division(Schaub et al.,2014;Tarlow et al.,2014;Yanger et al.,2014).Under severe injury or when hepatocyte proliferation is significantly impaired,cholangiocytes or biliary epithelial cells contribute to hepatocytes(Raven et al.,2017;Deng et al.,2018).展开更多
基金This work was supported by the National Science Foundation of China(82088101,31730112,32050087,91849202,31625019)National key Research&Development Program of China(2019YFA0110404,2019YFA0802000).
文摘The liver has remarkable capability to regenerate,employing mechanism to ensure the stable liver-to-bodyweight ratio for body homeostasis.The source of this regenerative capacity has received great attention over the past decade yet still remained controversial currently.Deciphering the sources for hepatocytes provides the basis for understanding tissue regeneration and repair,and also illustrates new potential therapeutic targets for treating liver diseases.In this review,we describe recent advances in genetic lineage tracing studies over liver stem cells,hepatocyte proliferation,and cell lineage conversions or cellular reprogramming.This review will also evaluate the technical strengths and limitations of methods used for studies on hepatocyte generation and cell fate plasticity in liver homeostasis,repair and regeneration.
文摘Following publication of the original article(Pu and Zhou 2022),some errors were identified in the Back-ground and Hepatocyte proliferation sections.The updated three sentences have been highlighted in Bold typeface.
基金supported by the National Key Research and Development Program of China(2018YFA0107900 and 2018YFA0108100)the National Science Foundation of China(31730112 and 31625019)the China Postdoctoral Innovative Talent Support Program。
文摘Unravelling lineage plasticity and cellular contribution to hepatocytes provides valuable information for understanding sources that fuel homeostatic renewal of the liver(Miyajima et al.,2014).In the adult stage,hepatocytes are mainly self-renewed through cell division(Schaub et al.,2014;Tarlow et al.,2014;Yanger et al.,2014).Under severe injury or when hepatocyte proliferation is significantly impaired,cholangiocytes or biliary epithelial cells contribute to hepatocytes(Raven et al.,2017;Deng et al.,2018).
