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PULLBACK EXPONENTIAL ATTRACTORS FOR THE NON-AUTONOMOUS MICROPOLAR FLUID FLOWS
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作者 wenlong sun Yeping LI 《Acta Mathematica Scientia》 SCIE CSCD 2018年第4期1370-1392,共23页
This paper investigates the pullback asymptotic behaviors for the non-autonomous micropolar fluid flows in 2D bounded domains. We use the energy method, combining with some important properties of the generated proces... This paper investigates the pullback asymptotic behaviors for the non-autonomous micropolar fluid flows in 2D bounded domains. We use the energy method, combining with some important properties of the generated processes, to prove the existence of pullback exponential attractors and global pullback attractors and show that they both with finite fractal dimension. Further, we give the relationship between global pullback attractors and pullback exponential attractors. 展开更多
关键词 micropolar fluid flow pullback exponential attractor global pullback attractor fractal dimension enstrophy equality
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Network pharmacology analysis to explore mechanism of Three Flower Tea against nonalcoholic fatty liver disease with experimental support using high-fat diet-induced rats 被引量:5
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作者 Peixuan Wu Shufei Liang +7 位作者 Yanping He Rui Lv Bendong Yang Meng Wang Chao Wang Yong Li Xinhua Song wenlong sun 《Chinese Herbal Medicines》 CAS 2022年第2期273-282,共10页
Objective:Nonalcoholic fatty liver disease(NAFLD)has become a common chronic liver disease that is harmful to human health.Moreover,there is currently no FDA-approved first-line drug for the treatment of nonalcoholic ... Objective:Nonalcoholic fatty liver disease(NAFLD)has become a common chronic liver disease that is harmful to human health.Moreover,there is currently no FDA-approved first-line drug for the treatment of nonalcoholic steatohepatitis(NASH)or NAFLD.Traditional Chinese medicine(TCM)is widely used to ameliorate liver diseases,such as the traditional ancient recipe called Three Flower Tea(TFT),which consists of double rose(Rosa rugosa),white chrysanthemum(Chrysanthemum morifolium),and Daidaihua(Citrus aurantium).However,the mechanisms of the action of TFT are not clear.Therefore,this study aimed to elucidate the mechanisms of TFT against NAFLD in high-fat diet(HFD)-induced rats.Methods:This study utilized bioinformatics and network pharmacology to establish the active and potential ingredient-target networks of TFT.Furthermore,a protein–protein interaction(PPI)network was constructed,and enrichment analysis was performed to determine the key targets of TFT against NAFLD.Furthermore,an animal experiment was conducted to evaluate the therapeutic effect and confirm the key targets of TFT against NAFLD.Results:A total of 576 NAFLD-related genes were searched in Gene Cards,and under the screening criteria of oral bioavailability(OB)≥30%and drug-likeness(DL)≥0.18,a total of 19 active ingredients and 210 targets were identified in TFT.Network pharmacology analysis suggested that 55 matching targets in PPIs were closely associated with roles for NAFLD treatment.Through the evaluation of network topology parameters,four key central genes,PPARγ,SREBP,AKT,and RELA,were identified.Furthermore,animal experiments indicated that TFT could reduce plasma lipid profiles,hepatic lipid profiles and hepatic fat accumulation,improve liver function,suppress inflammatory factors,and reduce oxidative stress.Through immunoblotting and immunofluorescence analysis,PPARγ,SREBP,AKT,and RELA were confirmed as targets of TFT in HFD-induced rats.Conclusion:In summary,our results indicate that TFT can prevent and treat NAFLD via multiple targets,including lipid accumulation,antioxidation,insulin sensitivity,and inflammation. 展开更多
关键词 network pharmacology nonalcoholic fatty liver disease Three Flower Tea
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Suppressor tRNA in gene therapy
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作者 Jingjing Ruan Xiaoxiao Yu +7 位作者 Huixia Xu Wenrui Cui Kaiye Zhang Chenyang Liu wenlong sun Xiaodan Huang Lei An Yue Zhang 《Science China(Life Sciences)》 SCIE CAS 2024年第10期2120-2131,共12页
Suppressor tRNAs are engineered or naturally occurring transfer RNA molecules that have shown promise in gene therapy for diseases caused by nonsense mutations,which result in premature termination codons(PTCs)in codi... Suppressor tRNAs are engineered or naturally occurring transfer RNA molecules that have shown promise in gene therapy for diseases caused by nonsense mutations,which result in premature termination codons(PTCs)in coding sequence,leading to truncated,often nonfunctional proteins.Suppressor t RNAs can recognize and pair with these PTCs,allowing the ribosome to continue translation and produce a full-length protein.This review introduces the mechanism and development of suppressor t RNAs,compares suppressor tRNAs with other readthrough therapies,discusses their potential for clinical therapy,limitations,and obstacles.We also summarize the applications of suppressor tRNAs in both in vitro and in vivo,offering new insights into the research and treatment of nonsense mutation diseases. 展开更多
关键词 suppressor tRNA PTC nonsense mutation readthrough gene therapy
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