66kV高压线下底净空临近既有高路堤铁路营运线桩基施工技术

随着中国经济的飞速发展,交通运输铁路也越来越多,高压线及临近高路堤铁路下施工工程难度不言而喻。66kV高压线下底净空临近既有高路堤铁路营运线桩基施工技术备受关注,以新建铁路用特大桥40#墩及41#墩临近既有高路堤运营铁路和66kV高压线双重不利因素下的桩基工程为背景,对高压线及临近高路堤铁路下钻孔灌注桩施工进行了风险分析,并从施工技术措施、现场管控、应急预案三个方面对施工安全防护进行深入的论述,取得了较好的社会经济效益。

Research on the Model of Consumer Health Information Seeking Behavior via Social Media

Purpose: We aim to create a model of consumer health information seeking behavior via social media, then to have a better understand of it. After that further efforts should be made to provide targeted recommendations for media managers to promote health communication via social media. Methods: Our custom model was derived from literature review, empirical research was tested by the use of questionnaire investigation, and then the collected data were analyzed by structural equation model tool SmartPLS. Finally, the custom model was modified according to the experimental results of SmartPLS. Results: A total of 239 (66.39%) of the respondents were female and 121 (33.61%) were male. The maximum of two stages of age were 18 - 29 (70.56%), 30 - 39 (13.89%). Wechat (60.28%), QQ Zone (55.22%), Micro-blog (48.89%) were the most commonly used social media to obtain health information. About 44.72% of respondents used social media to obtain health information multiple times a day. The whole numerical values of AVE, cronbach’s alpha, CR and square roots of AVE were above the benchmarks of themselves and showed great reliability and validity. All the 11 hypotheses had obvious statistical significance, the P-value of eight path coefficients exhibited <0.001, one path coefficient exhibited <0.01 and two path coefficients exhibited <0.05. Conclusions: A suitable model of consumer health information seeking behavior via social media was created and some inner relationships were found. Namely, gratification of health information and its platform had a positive effect on attitudes toward health information seeking behavior. Health information literacy and health status were proved to have a significant influence on attitudes toward health information seeking behavior, subject norms and perceived behavioral control respectively. In addition, attitudes toward the health information seeking behavior, subject norms and perceived behavioral control were proved to positively associate with health information seeking behavior intention.

Assessing the inhibition efficacy of clinical drugs against the main proteases of SARS-CoV-2 variants and other coronaviruses

The rapid evolution of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)mainly due to its high mutation rate and rapid viral replication,has led to new variants resistant to the available vaccines and monoclonal antibodies.In contrast,oral clinical drugs targeting viral protease and RNA polymerase remain effective against Omicron variants[1].Main protease(Mpro)plays a crucial role in the maturation and replication of viral strains,making it an attractive target for developing antiviral drugs.Nirmatrelvir(NTV)is the first-in-class Mpro peptidomimetic covalent inhibitor known as“Paxlovid”approved in 2021 by the Food and Drug Administration[2].Nevertheless,NTV-resistant Mpro mutants particularly the E166V mutation,have been characterized in the Global Initiative on Sharing Avian Influenza Data(GISAID)database[3]and reported in COVID-19 patients[4,5].

A transcriptome-based analysis reveals functional differences among Dendrobium officinale Kimura&Migo species from different growing regions and with different quality levels

Dendrobium officinale Kimura&Migo(D.officinale)is a common,high medicinal value food and herbal medicine used in the treatment of yin-deficient diseases.Adulterants obtained with similar inexpensive species of Dendrobium plants are available in the market.However,Dendrobium species with different quality levels or from different regions as well as analogous species have a similar appearance,which makes the discrimination of Dendrobium species difficult.Reliable objective methods for authenticating D.officinale are lacking.Here,samples of Dendrobium officinale Kimura&Migo(D.officinale)from two regions with three quality levels and sample of the analogous species Dendrobium compactum Rolfe ex W.Hackett(D.compactum)were subjected to genome-wide biological response fingerprinting(BioReF)in RAW264.7 cells by RNA sequencing.The biological pathways affected by these samples could distinguish D.officinale from D.compactum.The high-quality D.officinale samples from Yunnan exhibited the strongest inhibition of lipopolysaccharide(LPS)induced inflammatory genes and pathways,followed by samples from Myanmar.The medium-and low-quality samples from Yunnan exhibited weaker effects,and D.compactum exerted mild effects.The RNA sequencing results were strengthened by the results from analyses of the expression of the inflammation-related genes Il6,Ccl5,and Cox2 and the production of nitric oxide.Thus,transcriptomic profiling can be used to evaluate the quality of D.officinale and distinguish its origin.