Introduction:Pneumoconiosis emerges as the most critical and prevalent occupational disease in China at present,according to research.Studies indicate that pneumoconiosis may indeed impact the body’s phospholipid met...Introduction:Pneumoconiosis emerges as the most critical and prevalent occupational disease in China at present,according to research.Studies indicate that pneumoconiosis may indeed impact the body’s phospholipid metabolism.Methods:In this study,serum samples were taken from 46 paired participants,which included patients with pneumoconiosis and dust-exposed workers.We employed ultra-performance liquid chromatographytandem mass spectrometry(UPLC-MS/MS)technology in targeted lipidomics to investigate serum target phospholipids.Initially,a pilot study was conducted with a selection of 24 pneumoconiosis patients and 24 dust-exposed workers,using both univariate and multivariate statistical analyses to preliminarily identify significant differences in phospholipids.Subsequent to this,the remaining subjects were engaged in a validation study,wherein receiver operating characteristic(ROC)analysis was performed to further substantiate the screening potency of potential lipid biomarkers for pneumoconiosis.Results:The pilot study revealed significantly reduced serum levels of 16∶0 lysophosphatidylcholines(Lyso PC),18∶0–18∶1 phosphatidylglycerol(PG),18∶0–18∶1 phosphatidylethanolamine(PE),18∶0 PE,and 18∶1 lysophosphatidylethanolamine(Lyso PE)in the case group in comparison to the control group.Additionally,18∶0 PE,18∶0–18∶1 PE,and 18∶1 Lyso PE emerged as significant phospholipids with superior diagnostic values[area under the curve(AUC)>0.7].A diagnostic model was established,built on 16∶0 PC and 18∶0 PE(AUC>0.8).In the ROC analyses of validation studies,the 18∶0–18∶1 PE and this diagnostic model demonstrated excellent screening efficiency(AUC>0.7).Discussion:A significant divergence in phospholipid metabolism has been observed between pneumoconiosis patients and dust-exposed workers.The 18∶0–18∶1 PE present in serum could potentially function as a lipid biomarker for pneumoconiosis.Additionally,diagnostic models were developed relying on 16∶0 PC and 18∶0 PE,proving to have superior screening efficiency.展开更多
La0.1Ba0.9Fe12O19 powders with similar hexagonal crystal structure to Ba Fe12O19 have been successfully synthesized using polymer precursor method. The powders were suppressed into pellets, which were sintered into ce...La0.1Ba0.9Fe12O19 powders with similar hexagonal crystal structure to Ba Fe12O19 have been successfully synthesized using polymer precursor method. The powders were suppressed into pellets, which were sintered into ceramics at 1,300 °C for 1 h. The structure and morphology of the ceramics have been determined by X-ray diffraction(XRD) and field emission scanning electron microscopy(FESEM). Clear electric hysteresis loops upon different amplitude of external fields indicates that La0.1Ba0.9Fe12O19 is a kind of possible ferroelectric compound. The maximum remnant polarization of La0.1Ba0.9Fe12O19 ceramic is estimated to be *9.6 l C/cm2. The Fe O6 octahedron in its perovskite-like hexagonal unit cell as well as the shift of Fe3?off the center of octahedron are proposed to be the origin of electric polarization in La0.1Ba0.9Fe12O19. Simultaneous occurrence of large ferroelectricity and strong ferromagnetism has been observed in La0.1Ba0.9Fe12O19 ceramics. More interestingly, this compound demonstrates electronic polarization behavior being actuated by an applied magnetic field, indicating the existence of magnetoelectric(ME) coupling effect in the La0.1Ba0.9Fe12O19 ceramics. Our results may lead to new device applications such as magnetically recorded ferroelectric memory.展开更多
基金The National Key Research&Development Program of China(No.2021YFC 2500700).
文摘Introduction:Pneumoconiosis emerges as the most critical and prevalent occupational disease in China at present,according to research.Studies indicate that pneumoconiosis may indeed impact the body’s phospholipid metabolism.Methods:In this study,serum samples were taken from 46 paired participants,which included patients with pneumoconiosis and dust-exposed workers.We employed ultra-performance liquid chromatographytandem mass spectrometry(UPLC-MS/MS)technology in targeted lipidomics to investigate serum target phospholipids.Initially,a pilot study was conducted with a selection of 24 pneumoconiosis patients and 24 dust-exposed workers,using both univariate and multivariate statistical analyses to preliminarily identify significant differences in phospholipids.Subsequent to this,the remaining subjects were engaged in a validation study,wherein receiver operating characteristic(ROC)analysis was performed to further substantiate the screening potency of potential lipid biomarkers for pneumoconiosis.Results:The pilot study revealed significantly reduced serum levels of 16∶0 lysophosphatidylcholines(Lyso PC),18∶0–18∶1 phosphatidylglycerol(PG),18∶0–18∶1 phosphatidylethanolamine(PE),18∶0 PE,and 18∶1 lysophosphatidylethanolamine(Lyso PE)in the case group in comparison to the control group.Additionally,18∶0 PE,18∶0–18∶1 PE,and 18∶1 Lyso PE emerged as significant phospholipids with superior diagnostic values[area under the curve(AUC)>0.7].A diagnostic model was established,built on 16∶0 PC and 18∶0 PE(AUC>0.8).In the ROC analyses of validation studies,the 18∶0–18∶1 PE and this diagnostic model demonstrated excellent screening efficiency(AUC>0.7).Discussion:A significant divergence in phospholipid metabolism has been observed between pneumoconiosis patients and dust-exposed workers.The 18∶0–18∶1 PE present in serum could potentially function as a lipid biomarker for pneumoconiosis.Additionally,diagnostic models were developed relying on 16∶0 PC and 18∶0 PE,proving to have superior screening efficiency.
文摘La0.1Ba0.9Fe12O19 powders with similar hexagonal crystal structure to Ba Fe12O19 have been successfully synthesized using polymer precursor method. The powders were suppressed into pellets, which were sintered into ceramics at 1,300 °C for 1 h. The structure and morphology of the ceramics have been determined by X-ray diffraction(XRD) and field emission scanning electron microscopy(FESEM). Clear electric hysteresis loops upon different amplitude of external fields indicates that La0.1Ba0.9Fe12O19 is a kind of possible ferroelectric compound. The maximum remnant polarization of La0.1Ba0.9Fe12O19 ceramic is estimated to be *9.6 l C/cm2. The Fe O6 octahedron in its perovskite-like hexagonal unit cell as well as the shift of Fe3?off the center of octahedron are proposed to be the origin of electric polarization in La0.1Ba0.9Fe12O19. Simultaneous occurrence of large ferroelectricity and strong ferromagnetism has been observed in La0.1Ba0.9Fe12O19 ceramics. More interestingly, this compound demonstrates electronic polarization behavior being actuated by an applied magnetic field, indicating the existence of magnetoelectric(ME) coupling effect in the La0.1Ba0.9Fe12O19 ceramics. Our results may lead to new device applications such as magnetically recorded ferroelectric memory.
