Colorectal cancer(CRC),one of the most common malignant diseases,ranks second in morbidity and third in mortality among all cancers worldwide1.The liver is the most common site of distant metastasis in CRC.Liver metas...Colorectal cancer(CRC),one of the most common malignant diseases,ranks second in morbidity and third in mortality among all cancers worldwide1.The liver is the most common site of distant metastasis in CRC.Liver metastasis is also the main cause of death in patients with CRC.Approximately 25%of patients with CRC have liver metastasis detected at the initial diagnosis,and approximately 50%of patients eventually develop liver metastasis during disease progression.Liver metastasis severely affects the prognosis of patients with CRC.展开更多
Perovskite solar cells with TiO_2 electron transport layers exhibit power conversion efficiency(PCE) as high as 22.7% in single cells. However, the preparation process of the TiO_2 layer is adopted by an unscalable me...Perovskite solar cells with TiO_2 electron transport layers exhibit power conversion efficiency(PCE) as high as 22.7% in single cells. However, the preparation process of the TiO_2 layer is adopted by an unscalable method or requires high-temperature sintering, which precludes its potential use for mass production of flexible devices. In this study, a scalable low-temperature softcover-assisted hydrolysis(SAH) method is presented,where the precursor solution is sandwiched between a soft cover and preheated substrate to form a closed hydrolysis environment. Compact homogeneous TiO_2 films with a needle-like structure were obtained after the hydrolysis of a TiCl_4 aqueous solution. Moreover, by careful optimization of the TiO_2 fabrication conditions, a high PCE of 14.01% could be achieved for a solar module(4 × 4 cm^2) prepared using the SAH method. This method provides a novel approach for the efficient scale-up of the low-temperature TiO_2 film growth for industrial applications.展开更多
Electric furnace short process steelmaking is one of the most important steelmaking methods in the world today, and the waste heat recovery potential of electric furnace flue gas is huge.?The research on the recovery ...Electric furnace short process steelmaking is one of the most important steelmaking methods in the world today, and the waste heat recovery potential of electric furnace flue gas is huge.?The research on the recovery of electric furnace flue gas waste heat is of great significance. In order to make better use of this part of the heat,?in this paper, a compound cycle of nitrogen Brayton cycle as a first-order cycle and toluene transcritical Rankine cycle as a second-order cycle is proposed to recover waste heat from furnace flue gas in steelmaking process for power generation. A mathematical model was established with the net output power as the objective function and the initial expansion pressure, the final expansion pressure, the initial expansion temperature and the initial pressure of the second cycle as the independent variables. The effect of multivariate on the net output power of the waste heat power generation cycle is studied, and then, the optimal parameters of the compound cycle are determined. The results show that under the general electric furnace steelmaking process, the power generation efficiency of this new cycle can be increased by 21.02% compared with the conventional cycle.展开更多
Large-scale and complex process systems are essentially interconnected networks.The automated operation of such process networks requires the solution of control and optimization problems in a distributed manner.In th...Large-scale and complex process systems are essentially interconnected networks.The automated operation of such process networks requires the solution of control and optimization problems in a distributed manner.In this approach,the network is decomposed into several subsystems,each of which is under the supervision of a corresponding computing agent(controller,optimizer).The agents coordinate their control and optimization decisions based on information communication among them.In recent years,algorithms and methods for distributed control and optimization are undergoing rapid development.In this paper,we provide a comprehensive,up-to-date review with perspectives and discussions on possible future directions.展开更多
Complex biological environments and multiple physiological barriers significantly impede efficient accumulation and penetration of nanomaterials within tumor tissue for therapy.In situ energy conversion of nanomotors ...Complex biological environments and multiple physiological barriers significantly impede efficient accumulation and penetration of nanomaterials within tumor tissue for therapy.In situ energy conversion of nanomotors features autonomous movements and improves cancer treatment.However,one of the key challenges is to prepare nanomotors with an adequately small size,good biocompatibility,and precise positioning.Herein,we demonstrate a simple,ultrasmall,versatile,and real-time motion guidance strategy for magnetocatalytic CoPt@graphene navigators(MCGNs)that can enable highly efficient propulsion in the presence of H_(2)O_(2) or magnetic actuation.MCGNs act as highly diffusive delivery vehicles to promote tumor tissue targeting,and the amount of drug in the tumor was three times than without navigation.By engaging movements powered through in situ energy conversion,MCGNs gain considerable propulsion to penetrate a cell’s membrane and enhance intracellular delivery.展开更多
基金supported by the National Natural Science Foundation of China (Grant No.82072678)the Shanghai Science and Technology Committee Project (Grant No.23JC1401300)。
文摘Colorectal cancer(CRC),one of the most common malignant diseases,ranks second in morbidity and third in mortality among all cancers worldwide1.The liver is the most common site of distant metastasis in CRC.Liver metastasis is also the main cause of death in patients with CRC.Approximately 25%of patients with CRC have liver metastasis detected at the initial diagnosis,and approximately 50%of patients eventually develop liver metastasis during disease progression.Liver metastasis severely affects the prognosis of patients with CRC.
基金supported financially by the National Natural Science Foundation of China (Grants Nos. 11574199, 11674219)the Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning+1 种基金the Natural Science Foundation of Shanghai (17ZR1414800)the Baotou-SJTU innovation guidance fund Project (17H100000514)
文摘Perovskite solar cells with TiO_2 electron transport layers exhibit power conversion efficiency(PCE) as high as 22.7% in single cells. However, the preparation process of the TiO_2 layer is adopted by an unscalable method or requires high-temperature sintering, which precludes its potential use for mass production of flexible devices. In this study, a scalable low-temperature softcover-assisted hydrolysis(SAH) method is presented,where the precursor solution is sandwiched between a soft cover and preheated substrate to form a closed hydrolysis environment. Compact homogeneous TiO_2 films with a needle-like structure were obtained after the hydrolysis of a TiCl_4 aqueous solution. Moreover, by careful optimization of the TiO_2 fabrication conditions, a high PCE of 14.01% could be achieved for a solar module(4 × 4 cm^2) prepared using the SAH method. This method provides a novel approach for the efficient scale-up of the low-temperature TiO_2 film growth for industrial applications.
文摘Electric furnace short process steelmaking is one of the most important steelmaking methods in the world today, and the waste heat recovery potential of electric furnace flue gas is huge.?The research on the recovery of electric furnace flue gas waste heat is of great significance. In order to make better use of this part of the heat,?in this paper, a compound cycle of nitrogen Brayton cycle as a first-order cycle and toluene transcritical Rankine cycle as a second-order cycle is proposed to recover waste heat from furnace flue gas in steelmaking process for power generation. A mathematical model was established with the net output power as the objective function and the initial expansion pressure, the final expansion pressure, the initial expansion temperature and the initial pressure of the second cycle as the independent variables. The effect of multivariate on the net output power of the waste heat power generation cycle is studied, and then, the optimal parameters of the compound cycle are determined. The results show that under the general electric furnace steelmaking process, the power generation efficiency of this new cycle can be increased by 21.02% compared with the conventional cycle.
基金Supported by Division of Chemical,Bioengineering,Environmental and Transport Systems(CBET) of the National Science Foundation(NSF) of the United States of America
文摘Large-scale and complex process systems are essentially interconnected networks.The automated operation of such process networks requires the solution of control and optimization problems in a distributed manner.In this approach,the network is decomposed into several subsystems,each of which is under the supervision of a corresponding computing agent(controller,optimizer).The agents coordinate their control and optimization decisions based on information communication among them.In recent years,algorithms and methods for distributed control and optimization are undergoing rapid development.In this paper,we provide a comprehensive,up-to-date review with perspectives and discussions on possible future directions.
基金financially supported by the National Natural Science Foundation of China(grant no.21522501)Hunan Provincial Natural Science Foundation of China(grant no.2020RC4017)+1 种基金National Postdoctoral Program for Innovative Talents of China(grant no.BX20190111)the Science and Technology Development Fund,Macao(no.196/2017/A3).
文摘Complex biological environments and multiple physiological barriers significantly impede efficient accumulation and penetration of nanomaterials within tumor tissue for therapy.In situ energy conversion of nanomotors features autonomous movements and improves cancer treatment.However,one of the key challenges is to prepare nanomotors with an adequately small size,good biocompatibility,and precise positioning.Herein,we demonstrate a simple,ultrasmall,versatile,and real-time motion guidance strategy for magnetocatalytic CoPt@graphene navigators(MCGNs)that can enable highly efficient propulsion in the presence of H_(2)O_(2) or magnetic actuation.MCGNs act as highly diffusive delivery vehicles to promote tumor tissue targeting,and the amount of drug in the tumor was three times than without navigation.By engaging movements powered through in situ energy conversion,MCGNs gain considerable propulsion to penetrate a cell’s membrane and enhance intracellular delivery.
