Dear Editor,Adeno-associated virus(AAV)is one of the most powerful vectors for exogenous gene delivery.1 However,the risks associated with the high dosages of AAV administration that are required to achieve meaningful...Dear Editor,Adeno-associated virus(AAV)is one of the most powerful vectors for exogenous gene delivery.1 However,the risks associated with the high dosages of AAV administration that are required to achieve meaningful effects limit the applicability of this method.Generally,AAV only presents cell autonomous manner in infected cells.Besides,mosaic genetic editing or gene therapy would trigger global biological function restore by above 30–40%infective ratio in heart diseases.展开更多
基金This work was supported by the National Natural Science Foundation of China(81741025 and 81700360)Technology Project of Sichuan Province of China(2020YFS0102).
文摘Dear Editor,Adeno-associated virus(AAV)is one of the most powerful vectors for exogenous gene delivery.1 However,the risks associated with the high dosages of AAV administration that are required to achieve meaningful effects limit the applicability of this method.Generally,AAV only presents cell autonomous manner in infected cells.Besides,mosaic genetic editing or gene therapy would trigger global biological function restore by above 30–40%infective ratio in heart diseases.
