In cornfields,factors such as the similarity between corn seedlings and weeds and the blurring of plant edge details pose challenges to corn and weed segmentation.In addition,remote areas such as farmland are usually ...In cornfields,factors such as the similarity between corn seedlings and weeds and the blurring of plant edge details pose challenges to corn and weed segmentation.In addition,remote areas such as farmland are usually constrained by limited computational resources and limited collected data.Therefore,it becomes necessary to lighten the model to better adapt to complex cornfield scene,and make full use of the limited data information.In this paper,we propose an improved image segmentation algorithm based on unet.Firstly,the inverted residual structure is introduced into the contraction path to reduce the number of parameters in the training process and improve the feature extraction ability;secondly,the pyramid pooling module is introduced to enhance the network’s ability of acquiring contextual information as well as the ability of dealing with the small target loss problem;and lastly,Finally,to further enhance the segmentation capability of the model,the squeeze and excitation mechanism is introduced in the expansion path.We used images of corn seedlings collected in the field and publicly available corn weed datasets to evaluate the improved model.The improved model has a total parameter of 3.79 M and miou can achieve 87.9%.The fps on a single 3050 ti video card is about 58.9.The experimental results show that the network proposed in this paper can quickly segment corn weeds in a cornfield scenario with good segmentation accuracy.展开更多
Objective: To analyze the application value of psychological intervention in gastric cancer nursing. Methods: This study analyzes gastric cancer patients admitted to hospitals from May 2022 to May 2023. Based on resea...Objective: To analyze the application value of psychological intervention in gastric cancer nursing. Methods: This study analyzes gastric cancer patients admitted to hospitals from May 2022 to May 2023. Based on research requirements and patient willingness, 80 patients were selected and divided into observation and control groups using a lottery method. The control group received conventional nursing care, while the observation group received psychological intervention in addition to conventional nursing care. Results: After the psychological intervention, patients in the observation group showed significant improvements in anxiety and depression, better sleep quality, remarkable enhancement in psychological resilience, higher levels of health literacy, and increased nursing satisfaction compared to the control group (P < 0.05). Conclusion: Incorporating psychological intervention into the nursing care of gastric cancer patients enhances their psychological adjustment ability and improves treatment adherence.展开更多
Atom-level modulation of the coordination environment for single-atom catalysts(SACs)is considered as an effective strategy for elevating the catalytic performance.For the MNxsite,breaking the symmetrical geometry and...Atom-level modulation of the coordination environment for single-atom catalysts(SACs)is considered as an effective strategy for elevating the catalytic performance.For the MNxsite,breaking the symmetrical geometry and charge distribution by introducing relatively weak electronegative atoms into the first/second shell is an efficient way,but it remains challenging for elucidating the underlying mechanism of interaction.Herein,a practical strategy was reported to rationally design single cobalt atoms coordinated with both phosphorus and nitrogen atoms in a hierarchically porous carbon derived from metal-organic frameworks.X-ray absorption spectrum reveals that atomically dispersed Co sites are coordinated with four N atoms in the first shell and varying numbers of P atoms in the second shell(denoted as Co-N/P-C).The prepared catalyst exhibits excellent oxygen reduction reaction(ORR)activity as well as zinc-air battery performance.The introduction of P atoms in the Co-SACs weakens the interaction between Co and N,significantly promoting the adsorption process of ^(*)OOH,resulting in the acceleration of reaction kinetics and reduction of thermodynamic barrier,responsible for the increased intrinsic activity.Our discovery provides insights into an ultimate design of single-atom catalysts with adjustable electrocatalytic activities for efficient electrochemical energy conversion.展开更多
"Synthetic"allopolyploids recreated by interspecific hybridization play an important role in providing novel genomic variation for crop improvement.Such synthetic allopolyploids often undergo rapid genomic s..."Synthetic"allopolyploids recreated by interspecific hybridization play an important role in providing novel genomic variation for crop improvement.Such synthetic allopolyploids often undergo rapid genomic structural variation(SV).However,how such SV arises,is inherited and fixed,and how it affects important traits,has rarely been comprehensively and quantitively studied in advanced generation synthetic lines.A better understanding of these processes will aid breeders in knowing how to best utilize synthetic allopolyploids in breeding programs.Here,we analyzed three genetic mapping populations(735 DH lines)derived from crosses between advanced synthetic and conventional Brassica napus(rapeseed)lines,using whole-genome sequencing to determine genome composition.We observed high tolerance of large structural variants,particularly toward the telomeres,and preferential selection for balanced homoeologous exchanges(duplication/deletion events between the A and C genomes resulting in retention of gene/chromosome dosage between homoeologous chromosome pairs),including stable events involving whole chromosomes("pseudoeuploidy").Given the experimental design(all three populations shared a common parent),we were able to observe that parental SV was regularly inherited,showed genetic hitchhiking effects on segregation,and was one of the major factors inducing adjacent novel and larger SV.Surprisingly,novel SV occurred at low frequencies with no significant impacts on observed fertility and yield-related traits in the advanced generation synthetic lines.However,incorporating genome-wide SV in linkage mapping explained significantly more genetic variance for traits.Our results provide a framework for detecting and understanding the occurrence and inheritance of genomic SV in breeding programs,and support the use of synthetic parents as an important source of novel trait variation.展开更多
This study demonstrates the feasibility of producing three polysaccharides(neutral LJP-1,acidic LJP-2 and acidic LJP-3)with significant in vitro and in vivo anti-inflammatory activities from the flowers of Lonicera ja...This study demonstrates the feasibility of producing three polysaccharides(neutral LJP-1,acidic LJP-2 and acidic LJP-3)with significant in vitro and in vivo anti-inflammatory activities from the flowers of Lonicera japonica.The three polysaccharides differed in chemical composition,molecular weight(Mw)distribution,glycosidic linkage pattern,functional groups and morphology.They exhibited excellent protective effects(in a dose-dependent manner)in lipopolysaccharide-injured RAW264.7 macrophages and Cu SO4-damaged zebrafish via reducing NO production and inhibiting the overexpressions of inflammation-related transcription factors,inflammatory proteins and cytokines in the NF-κB/MAPK signaling pathways.Their antiinflammatory effects varied owing to their different molecular characteristics and chemical compositions.Overall,LJP-2 at 400μg/m L was the most effective.LJP-2 consisted mainly of→5)-α-L-Araf(1→,→4)-α-LGalp A(1→and→2)-α-L-Rhap(1→residues with terminal T-β-D-Glcp.Thus,honeysuckle flowers are good sources of anti-inflammatory polysaccharides,and precise fractionation enables the production of potent antiinflammatory agents for the development of functional foods and healthcare products.展开更多
Seed vigor is a crucial trait for the direct seeding of rice.Here we examined the genetic regulation of seed vigor traits in rice,including germination index(GI)and germination potential(GP),using a genome-wide associ...Seed vigor is a crucial trait for the direct seeding of rice.Here we examined the genetic regulation of seed vigor traits in rice,including germination index(GI)and germination potential(GP),using a genome-wide association study approach.One major quantitative trait locus,qGI6/qGP6,was identified simultaneously for both GI and GP.The candidate gene encoding the cytochrome c oxidase subunit 5B(OsCOX5B)was validated for qGI6/qGP6.The disruption of OsCOX5B caused the vigor traits to be significantly lower in Oscox5b mutants than in the japonica Nipponbare wild type(WT).Gene co-expression analysis revealed that OsCOX5B influences seed vigor mainly by modulating the tricarboxylic acid cycle process.The glucose levels were significantly higher while the pyruvic acid and adenosine triphosphate levels were significantly lower in Oscox5b mutants than in WT during seed germination.The elite haplotype of OsCOX5B facilitates seed vigor by increasing its expression during seed germination.Thus,we propose that OsCOX5B is a potential target for the breeding of rice varieties with enhanced seed vigor for direct seeding.展开更多
To address the issues of low accuracy and high false positive rate in traditional Otsu algorithm for defect detection on infrared images of wind turbine blades(WTB),this paper proposes a technique that combines morpho...To address the issues of low accuracy and high false positive rate in traditional Otsu algorithm for defect detection on infrared images of wind turbine blades(WTB),this paper proposes a technique that combines morphological image enhancement with an improved Otsu algorithm.First,mathematical morphology’s differential multi-scale white and black top-hat operations are applied to enhance the image.The algorithm employs entropy as the objective function to guide the iteration process of image enhancement,selecting appropriate structural element scales to execute differential multi-scale white and black top-hat transformations,effectively enhancing the detail features of defect regions and improving the contrast between defects and background.Afterwards,grayscale inversion is performed on the enhanced infrared defect image to better adapt to the improved Otsu algorithm.Finally,by introducing a parameter K to adjust the calculation of inter-class variance in the Otsu method,the weight of the target pixels is increased.Combined with the adaptive iterative threshold algorithm,the threshold selection process is further fine-tuned.Experimental results show that compared to traditional Otsu algorithms and other improvements,the proposed method has significant advantages in terms of defect detection accuracy and reducing false positive rates.The average defect detection rate approaches 1,and the average Hausdorff distance decreases to 0.825,indicating strong robustness and accuracy of the method.展开更多
Terahertz time-domain spectroscopy is a kind of far-infrared spectroscopy technology,and its spectrum reflects the internal properties of substances with rich physical and chemical information,so the use of terahertz ...Terahertz time-domain spectroscopy is a kind of far-infrared spectroscopy technology,and its spectrum reflects the internal properties of substances with rich physical and chemical information,so the use of terahertz waves can be used to qualitatively identify food additives containing nitrogen elements.Analytic hierarchy process(AHP)was originally used to solve evaluation-type problems,and this paper introduces it into the field of terahertz spectral qualitative analysis,proposes a terahertz time-domain spectral qualitative identification method combined with analytic hierarchy process,and verifies the feasibility of the method by taking four common food additives(xylitol,L-alanine,sorbic acid,and benzoic acid)and two illegal additives(melamine,and Sudan Red No.I)as the objects of study.Firstly,the collected terahertz time-domain spectral data were pre-processed and transformed into a data set consisting of peaks,peak positions,peak numbers and overall trends;then,the data were divided into comparison and test sets,and a qualitative additive identification model incorporating analytic hierarchy process was constructed and parameter optimisation was performed.The results showed that the qualitative identification accuracies of additives based on single factors,i.e.,overall trend,peak value,peak position,and peak number,were 80.23%,70.93%,67.44%,and 40.70%,respectively,whereas the identification accuracy of the analytic hierarchy process qualitative identification method based on multi-factors could be improved to 92.44%.In addition,the fuzzy characterisation of the absorption spectrum data was binarised in the data pre-processing stage and used as the base data for the overall trend,and the recognition accuracy was improved to 94.19%by combining the fuzzy characterisation method of such data with the hierarchical analysis qualitative recognition model.The results show that it is feasible to use terahertz technology to identify different varieties of additives,and this paper constructs a hierarchical analytical qualitative model with better effect,which provides a new means for food additives detection,and the method is simple in steps,with a small demand for samples,which is suitable for the rapid detection of small samples.展开更多
Mobile operators face the challenge of how to best design a service-centric network that can effectively process the rapidly increasing number of bandwidth-intensive user requests while providing a higher quality of e...Mobile operators face the challenge of how to best design a service-centric network that can effectively process the rapidly increasing number of bandwidth-intensive user requests while providing a higher quality of experience(QoE). Existing content distribution networks(CDN) and mobile content distribution networks(mCDN) have both latency and throughput limitations due to being multiple network hops away from end-users. Here, we first propose a new Personalized Edge Caching System(PECS) architecture that employs big data analytics and mobile edge caching to provide personalized service access at the edge of the mobile network. Based on the proposed system architecture, the edge caching strategy based on user behavior and trajectory is analyzed. Employing our proposed PECS strategies, we use data mining algorithms to analyze the personalized trajectory and service usage patterns. Our findings provide guidance on how key technologies of PECS can be employed for current and future networks. Finally, we highlight the challenges associated with realizing such a system in 5G and beyond.展开更多
Objective:To analyze the effect of apatinib,S-1 combined with paclitaxel perfusion on malignant seroperitoneum of gastric cancer.Methods:From December 2019 to May 2020,172 patients with gastric cancer treated in our h...Objective:To analyze the effect of apatinib,S-1 combined with paclitaxel perfusion on malignant seroperitoneum of gastric cancer.Methods:From December 2019 to May 2020,172 patients with gastric cancer treated in our hospital were randomly divided into two groups:observation group and control group,86 cases each.The control group adopted the method of S-1 combined with paclitaxel perfusion therapy in the treatment of malignant seroperitoneum of gastric cancer.The observation group was given oral apatinib on the basis of S-1 combined with paclitaxel perfusion therapy,and the dosage was 500 mg/d.Results:The total effective treatment in the control group was 43.02%,while the total effective rate in the observation group was 69.77%;the drug resistance of the two groups of patients increased and the adverse reactions were low.Conclusion:Apatinib and S-1 combined with paclitaxel perfusion therapy can effectively improve the treatment effect,stabilize the patient's condition,increase the patient's drug resistance to adverse reactions,and have a good prognosis.展开更多
Lateral heterogeneity of a cell membrane,including the formation of lipid raft-like clusters and the inter-leaflet coupling of specific phase domains,is crucial for cellular functions such as membrane trafficking and ...Lateral heterogeneity of a cell membrane,including the formation of lipid raft-like clusters and the inter-leaflet coupling of specific phase domains,is crucial for cellular functions such as membrane trafficking and transmembrane signaling.However,the wide diversity in lipid species and the consequent complexity in lipid-lipid interplays hinder our understanding of the underlying mechanism.In this work,with coarse-grained molecular dynamics simulations,the effect of lipid tail structures on the phase behavior of a model ternary lipid membrane was systematically explored.A serial of 27 lipid membrane systems consisting of saturated,unsaturated lipids,and cholesterol(Chol)molecules,at a fixed molar ratio of 4:4:2 while varying in lipid structures including tail length,unsaturation degree,and/or position of unsaturated atoms,were constructed.These structural factors were found to exert sophisticated influences on packing states of the constituent molecules,especially Chol,in a bilayer,and modulate the complicated entropy-enthalpy competition of the membrane system accordingly.Specifically,an appropriate difference in effective tail length and distinct feature of the tail ends between the saturated and unsaturated lipid compositions promised an enhanced phase separation of the membrane into the Chol-rich Lo and Chol-poor Ld phase domains,with a full inter-leaflet coupling of each domain.Our results provide insights into the lipid organizations and segregations of the cellular plasma membrane.展开更多
Habitat restoration is an effective method for improving landscape connectivity,which can reduce habitat fragmentation.Maintaining landscape connectivity could promote connections between habitat,which is extremely es...Habitat restoration is an effective method for improving landscape connectivity,which can reduce habitat fragmentation.Maintaining landscape connectivity could promote connections between habitat,which is extremely essential to preserve gene flow and population viability.This study proposes a methodological framework to analyze landscape connectivity for Asian elephant habitat conservation,aiming to provide practical options for reducing habitat fragmentation and improving habitat connectivity.Our approach involved combining a species distribution model using MaxEnt and landscape functional connectivity models using graph theory to assess the impact on connectivity improvement via farmland/plantation restoration as habitat.The results showed that:(1)there were 119 suitable habitat patches of Asian elephant covering a total area of 1952.41 km^(2).(2)The connectivity between habitats improved significantly after vegetation restoration and the gain first decreased and then increased with the increase of dispersal distance.(3)The first few new habitat patches that were identified played an important role in improving connectivity,and the variation rate of connectivity gradually leveled off as the number of new habitats increased.(4)Prioritization of the 25 best new habitat patches increased connectivity from 0.54%to 5.59%as the dispersal distance increased and mainly was located between two Asian elephant distribution regions and two components.Establishment of new habitat patches was effective for improving or restoring connectivity.Our findings can be used as guidance for improving the studied fragmented Asian elephant habitats,and they can also be used as a reference for the habitat restoration of other endangered species heavily affected by habitat fragmentation.展开更多
We proposed a hybrid imaging scheme to estimate a high-resolution absolute depth map from low photon counts. It leverages measurements of photon arrival times from a single-photon LiDAR and an intensity image from a c...We proposed a hybrid imaging scheme to estimate a high-resolution absolute depth map from low photon counts. It leverages measurements of photon arrival times from a single-photon LiDAR and an intensity image from a conventional high-resolution camera. Using a tailored fusion algorithm, we jointly processed the raw measurements from both sensors and output a high-resolution absolute depth map. We scaled up the resolution by a factor of 10, achieving 1300 × 2611 pixels and extending ~4.7 times the unambiguous range. These results demonstrated the superior capability of long-range high-resolution 3D imaging without range ambiguity.展开更多
Atmospheric radiation is a major branch of atmospheric physics that encompasses the fundamental theories of atmospheric absorption,particle scattering(aerosols and clouds),and radiative transfer.Specifically,the simul...Atmospheric radiation is a major branch of atmospheric physics that encompasses the fundamental theories of atmospheric absorption,particle scattering(aerosols and clouds),and radiative transfer.Specifically,the simulations of atmospheric gaseous absorption and scattering properties of particles are the essential components of atmospheric radiative transfer models.Atmospheric radiation has important applications in weather,climate,data assimilation,remote sensing,and atmospheric detection studies.In PartⅠ,a comprehensive review of the progress in the field of gas absorption and particle scattering research over the past 30 years with a particular emphasis on the contributions from Chinese scientists is presented.The review of gas absorption includes the construction of absorption databases,the impact of different atmospheric absorption algorithms on radiative calculations,and their applications in weather and climate models and remote sensing.The review on particle scattering starts with the theoretical and computational methods and subsequently explores the optical modeling of aerosols and clouds in remote sensing and atmospheric models.Additionally,the paper discusses potential future research directions in this field.展开更多
In the framework of vigorous promotion of low-carbon power system growth as well as economic globalization,multi-resource penetration in active distribution networks has been advancing fiercely.In particular,distribut...In the framework of vigorous promotion of low-carbon power system growth as well as economic globalization,multi-resource penetration in active distribution networks has been advancing fiercely.In particular,distributed generation(DG)based on renewable energy is critical for active distribution network operation enhancement.To comprehensively analyze the accessing impact of DG in distribution networks from various parts,this paper establishes an optimal DG location and sizing planning model based on active power losses,voltage profile,pollution emissions,and the economics of DG costs as well as meteorological conditions.Subsequently,multiobjective particle swarm optimization(MOPSO)is applied to obtain the optimal Pareto front.Besides,for the sake of avoiding the influence of the subjective setting of the weight coefficient,the decisionmethod based on amodified ideal point is applied to execute a Pareto front decision.Finally,simulation tests based on IEEE33 and IEEE69 nodes are designed.The experimental results show thatMOPSO can achieve wider and more uniformPareto front distribution.In the IEEE33 node test system,power loss,and voltage deviation decreased by 52.23%,and 38.89%,respectively,while taking the economy into account.In the IEEE69 test system,the three indexes decreased by 19.67%,and 58.96%,respectively.展开更多
Single-nucleotide polymorphisms(SNPs)are the most abundant form of genomic polymorphisms and are widely used in population genetics research.Here,high-throughput sequencing was used to examine the genome-level diversi...Single-nucleotide polymorphisms(SNPs)are the most abundant form of genomic polymorphisms and are widely used in population genetics research.Here,high-throughput sequencing was used to examine the genome-level diversity,population structure,and relationships of apricot,which are important for germplasm conservation and molecular breeding.Restriction site-associated DNA sequencing(RAD-seq)was adopted to sequence 168 Prunus spp.accessions distributed in five ecological groups,including 74 accessions of cultivated Prunus armeniaca L.and 94 accessions of wild apricots(P.armeniaca L.and Prunus sibirica L.),which generated 417,961 high-quality SNPs.We used cluster,genetic structure,and principal component analyses to examine the genetic diversities and genetic relationships of the 168 accessions.The Dzhungar-Ili ecological group accessions showed the highest genetic diversity in terms of private allele number,observed heterozygosity,and nucleotide diversity.We speculate that the Central Asian ecological group accessions were domesticated from the Dzhungar-Ili ecological group accessions.The population structure and gene flow of the North China and European ecological group accessions suggested a genetic background of P.sibirica.We argue that the two groups should be considered hybrid swarms connected to P.sibirica by continuous and extensive gene flow.P.armeniaca originated in Northwest China(Ili Valley),subsequently spread throughout Central Asia,and eventually spread to Europe.In addition,selective sweep signatures in P.armeniaca during domestication from wild to cultivated apricots,combined with differentially expressed genes,underlie distinct fruit traits,including sugars,aromas,organic acids,and carotenoids.This study provides substantive and valuable genomic resources that will significantly advance apricot improvement and effective utilization.展开更多
Bohai Rim region is an important economic development area and a large carbon emission area in China.It is of great significance to explore the total factor energy efficiency and its influencing factors for the low ca...Bohai Rim region is an important economic development area and a large carbon emission area in China.It is of great significance to explore the total factor energy efficiency and its influencing factors for the low carbon transformation and high-quality development of the Bohai Rim region.Based on the total factor energy efficiency framework,the DDF-DEA model was used to calculate the total factor energy efficiency,and the internal and external differences of the total factor energy efficiency were further analyzed.The internal and external influencing factors were determined by ML index method and classical endogenous growth theory,and then the Tobit panel model was used to empirically analyze the action mechanism of all influencing factors of total factor energy efficiency in the Bohai Rim region.The results show that the pure technical efficiency,scale efficiency and technological progress among the internal influencing factors contribute to the improvement of energy efficiency in the Bohai Rim region.Industrial structure,industrial internal structure and ownership structure inhibit the improvement of energy efficiency.Energy consumption structure and energy endowment also have a negative impact on energy efficiency.Therefore,measures such as promoting technological progress,adjusting economic structure and optimizing energy structure will effectively improve total factor energy efficiency in the Bohai Rim region.展开更多
In heterogeneous catalytic reactions,supported metal catalysts have attracted increasing attention for the environmental remediation and industrial manufacture due to their inherent catalytic capacity.However,leaching...In heterogeneous catalytic reactions,supported metal catalysts have attracted increasing attention for the environmental remediation and industrial manufacture due to their inherent catalytic capacity.However,leaching,agglomeration,and poisoning of active metal particles lead to catalyst deactivation,thereby limiting their applications.To avoid this,strategies to protect the active metals from such inactivating processes are major areas of research.Emerging encapsulation strategies,in which active species are coated by protective shells,have proven to be a powerful technology to enhance catalytic performance by creating a well-developed structure about the active catalytic sites.This review highlights the recent advances on preparation method and application of encapsulated catalysts since 2016.Building upon the traditional confinement effect,new categories and extended concepts of encapsulation are introduced.In parallel,effects of encapsulation structure on performance and key factors controlling the structure of encapsulated catalyst are discussed definitely in this review.Finally,future perspectives on opportunities and challenges for further research in the field are given at the end of this paper.展开更多
Due to the essential role of cyclin D1 in regulating transition from G1 to S phase in cell cycle,aberrant cyclin D1 expression is a major oncogenic event in many types of cancers.In particular,the dysregulation of ubi...Due to the essential role of cyclin D1 in regulating transition from G1 to S phase in cell cycle,aberrant cyclin D1 expression is a major oncogenic event in many types of cancers.In particular,the dysregulation of ubiquitination-dependent degradation of cyclin D1 contributes to not only the pathogenesis of malignancies but also the refractory to cancer treatment regiments with CDK4/6 inhibitors.Here we show that in colorectal and gastric cancer patients,MG53 is downregulated in more than 80%of tumors compared to the normal gastrointestinal tissues from the same patient,and the reduced MG53 expression is correlated with increased cyclin D1 abundance and inferior survival.Mechanistically,MG53 catalyzes the K48-linked ubiquitination and subsequent degradation of cyclin D1.Thus,increased expression of MG53 leads to cell cycle arrest at G1,and thereby markedly suppresses cancer cell proliferation in vitro as well as tumor growth in mice with xenograft tumors or AOM/DSS induced-colorectal cancer.Consistently,MG53 deficiency results in accumulation of cyclin D1 protein and accelerates cancer cell growth both in culture and in animal models.These findings define MG53 as a tumor suppressor via facilitating cyclin D1 degradation,highlighting the therapeutic potential of targeting MG53 in treating cancers with dysregulated cyclin D1 turnover.展开更多
文摘In cornfields,factors such as the similarity between corn seedlings and weeds and the blurring of plant edge details pose challenges to corn and weed segmentation.In addition,remote areas such as farmland are usually constrained by limited computational resources and limited collected data.Therefore,it becomes necessary to lighten the model to better adapt to complex cornfield scene,and make full use of the limited data information.In this paper,we propose an improved image segmentation algorithm based on unet.Firstly,the inverted residual structure is introduced into the contraction path to reduce the number of parameters in the training process and improve the feature extraction ability;secondly,the pyramid pooling module is introduced to enhance the network’s ability of acquiring contextual information as well as the ability of dealing with the small target loss problem;and lastly,Finally,to further enhance the segmentation capability of the model,the squeeze and excitation mechanism is introduced in the expansion path.We used images of corn seedlings collected in the field and publicly available corn weed datasets to evaluate the improved model.The improved model has a total parameter of 3.79 M and miou can achieve 87.9%.The fps on a single 3050 ti video card is about 58.9.The experimental results show that the network proposed in this paper can quickly segment corn weeds in a cornfield scenario with good segmentation accuracy.
文摘Objective: To analyze the application value of psychological intervention in gastric cancer nursing. Methods: This study analyzes gastric cancer patients admitted to hospitals from May 2022 to May 2023. Based on research requirements and patient willingness, 80 patients were selected and divided into observation and control groups using a lottery method. The control group received conventional nursing care, while the observation group received psychological intervention in addition to conventional nursing care. Results: After the psychological intervention, patients in the observation group showed significant improvements in anxiety and depression, better sleep quality, remarkable enhancement in psychological resilience, higher levels of health literacy, and increased nursing satisfaction compared to the control group (P < 0.05). Conclusion: Incorporating psychological intervention into the nursing care of gastric cancer patients enhances their psychological adjustment ability and improves treatment adherence.
基金supported by the National Natural Science Foundation of China(51872115,12234018 and 52101256)Beijing Synchrotron Radiation Facility(BSRF,4B9A)。
文摘Atom-level modulation of the coordination environment for single-atom catalysts(SACs)is considered as an effective strategy for elevating the catalytic performance.For the MNxsite,breaking the symmetrical geometry and charge distribution by introducing relatively weak electronegative atoms into the first/second shell is an efficient way,but it remains challenging for elucidating the underlying mechanism of interaction.Herein,a practical strategy was reported to rationally design single cobalt atoms coordinated with both phosphorus and nitrogen atoms in a hierarchically porous carbon derived from metal-organic frameworks.X-ray absorption spectrum reveals that atomically dispersed Co sites are coordinated with four N atoms in the first shell and varying numbers of P atoms in the second shell(denoted as Co-N/P-C).The prepared catalyst exhibits excellent oxygen reduction reaction(ORR)activity as well as zinc-air battery performance.The introduction of P atoms in the Co-SACs weakens the interaction between Co and N,significantly promoting the adsorption process of ^(*)OOH,resulting in the acceleration of reaction kinetics and reduction of thermodynamic barrier,responsible for the increased intrinsic activity.Our discovery provides insights into an ultimate design of single-atom catalysts with adjustable electrocatalytic activities for efficient electrochemical energy conversion.
基金supported by the National Natural Science Foundation of China(NSFC,31970564,32000397,32171982)the Fundamental Research Funds for the Central Universities(2662023PY004)。
文摘"Synthetic"allopolyploids recreated by interspecific hybridization play an important role in providing novel genomic variation for crop improvement.Such synthetic allopolyploids often undergo rapid genomic structural variation(SV).However,how such SV arises,is inherited and fixed,and how it affects important traits,has rarely been comprehensively and quantitively studied in advanced generation synthetic lines.A better understanding of these processes will aid breeders in knowing how to best utilize synthetic allopolyploids in breeding programs.Here,we analyzed three genetic mapping populations(735 DH lines)derived from crosses between advanced synthetic and conventional Brassica napus(rapeseed)lines,using whole-genome sequencing to determine genome composition.We observed high tolerance of large structural variants,particularly toward the telomeres,and preferential selection for balanced homoeologous exchanges(duplication/deletion events between the A and C genomes resulting in retention of gene/chromosome dosage between homoeologous chromosome pairs),including stable events involving whole chromosomes("pseudoeuploidy").Given the experimental design(all three populations shared a common parent),we were able to observe that parental SV was regularly inherited,showed genetic hitchhiking effects on segregation,and was one of the major factors inducing adjacent novel and larger SV.Surprisingly,novel SV occurred at low frequencies with no significant impacts on observed fertility and yield-related traits in the advanced generation synthetic lines.However,incorporating genome-wide SV in linkage mapping explained significantly more genetic variance for traits.Our results provide a framework for detecting and understanding the occurrence and inheritance of genomic SV in breeding programs,and support the use of synthetic parents as an important source of novel trait variation.
基金supported by Key R&D Program of Shandong Province,China(2021CXGC010508)。
文摘This study demonstrates the feasibility of producing three polysaccharides(neutral LJP-1,acidic LJP-2 and acidic LJP-3)with significant in vitro and in vivo anti-inflammatory activities from the flowers of Lonicera japonica.The three polysaccharides differed in chemical composition,molecular weight(Mw)distribution,glycosidic linkage pattern,functional groups and morphology.They exhibited excellent protective effects(in a dose-dependent manner)in lipopolysaccharide-injured RAW264.7 macrophages and Cu SO4-damaged zebrafish via reducing NO production and inhibiting the overexpressions of inflammation-related transcription factors,inflammatory proteins and cytokines in the NF-κB/MAPK signaling pathways.Their antiinflammatory effects varied owing to their different molecular characteristics and chemical compositions.Overall,LJP-2 at 400μg/m L was the most effective.LJP-2 consisted mainly of→5)-α-L-Araf(1→,→4)-α-LGalp A(1→and→2)-α-L-Rhap(1→residues with terminal T-β-D-Glcp.Thus,honeysuckle flowers are good sources of anti-inflammatory polysaccharides,and precise fractionation enables the production of potent antiinflammatory agents for the development of functional foods and healthcare products.
基金supported by the Hainan Province Science and Technology Special Fund,China(ZDYF2023XDNY086)the Project of Sanya Yazhou Bay Science and Technology City,China(SCKJ-JYRC-2022-87)+2 种基金the Natural Science Foundation of Guangdong Province,China(2023A1515012052 and 2023A1515012092)the Guangzhou Science and Technology Plan Project,China(2023A04J1452 and 2023A04J0749)the Double First-class Discipline Promotion Project,China(2021B10564001).
文摘Seed vigor is a crucial trait for the direct seeding of rice.Here we examined the genetic regulation of seed vigor traits in rice,including germination index(GI)and germination potential(GP),using a genome-wide association study approach.One major quantitative trait locus,qGI6/qGP6,was identified simultaneously for both GI and GP.The candidate gene encoding the cytochrome c oxidase subunit 5B(OsCOX5B)was validated for qGI6/qGP6.The disruption of OsCOX5B caused the vigor traits to be significantly lower in Oscox5b mutants than in the japonica Nipponbare wild type(WT).Gene co-expression analysis revealed that OsCOX5B influences seed vigor mainly by modulating the tricarboxylic acid cycle process.The glucose levels were significantly higher while the pyruvic acid and adenosine triphosphate levels were significantly lower in Oscox5b mutants than in WT during seed germination.The elite haplotype of OsCOX5B facilitates seed vigor by increasing its expression during seed germination.Thus,we propose that OsCOX5B is a potential target for the breeding of rice varieties with enhanced seed vigor for direct seeding.
基金supported by Natural Science Foundation of Jilin Province(YDZJ202401352ZYTS).
文摘To address the issues of low accuracy and high false positive rate in traditional Otsu algorithm for defect detection on infrared images of wind turbine blades(WTB),this paper proposes a technique that combines morphological image enhancement with an improved Otsu algorithm.First,mathematical morphology’s differential multi-scale white and black top-hat operations are applied to enhance the image.The algorithm employs entropy as the objective function to guide the iteration process of image enhancement,selecting appropriate structural element scales to execute differential multi-scale white and black top-hat transformations,effectively enhancing the detail features of defect regions and improving the contrast between defects and background.Afterwards,grayscale inversion is performed on the enhanced infrared defect image to better adapt to the improved Otsu algorithm.Finally,by introducing a parameter K to adjust the calculation of inter-class variance in the Otsu method,the weight of the target pixels is increased.Combined with the adaptive iterative threshold algorithm,the threshold selection process is further fine-tuned.Experimental results show that compared to traditional Otsu algorithms and other improvements,the proposed method has significant advantages in terms of defect detection accuracy and reducing false positive rates.The average defect detection rate approaches 1,and the average Hausdorff distance decreases to 0.825,indicating strong robustness and accuracy of the method.
基金funded by Key Technology Tackling Programme of Inner Mongolia,grant number2021GG0361funded by Basic Research Operating Costs of Colleges and Universities Directly Under the Inner Mongolia Autonomous Region Project。
文摘Terahertz time-domain spectroscopy is a kind of far-infrared spectroscopy technology,and its spectrum reflects the internal properties of substances with rich physical and chemical information,so the use of terahertz waves can be used to qualitatively identify food additives containing nitrogen elements.Analytic hierarchy process(AHP)was originally used to solve evaluation-type problems,and this paper introduces it into the field of terahertz spectral qualitative analysis,proposes a terahertz time-domain spectral qualitative identification method combined with analytic hierarchy process,and verifies the feasibility of the method by taking four common food additives(xylitol,L-alanine,sorbic acid,and benzoic acid)and two illegal additives(melamine,and Sudan Red No.I)as the objects of study.Firstly,the collected terahertz time-domain spectral data were pre-processed and transformed into a data set consisting of peaks,peak positions,peak numbers and overall trends;then,the data were divided into comparison and test sets,and a qualitative additive identification model incorporating analytic hierarchy process was constructed and parameter optimisation was performed.The results showed that the qualitative identification accuracies of additives based on single factors,i.e.,overall trend,peak value,peak position,and peak number,were 80.23%,70.93%,67.44%,and 40.70%,respectively,whereas the identification accuracy of the analytic hierarchy process qualitative identification method based on multi-factors could be improved to 92.44%.In addition,the fuzzy characterisation of the absorption spectrum data was binarised in the data pre-processing stage and used as the base data for the overall trend,and the recognition accuracy was improved to 94.19%by combining the fuzzy characterisation method of such data with the hierarchical analysis qualitative recognition model.The results show that it is feasible to use terahertz technology to identify different varieties of additives,and this paper constructs a hierarchical analytical qualitative model with better effect,which provides a new means for food additives detection,and the method is simple in steps,with a small demand for samples,which is suitable for the rapid detection of small samples.
基金supported in part by the Fundamental Research Funds for the Central Universities of China (No. 2018CUCTJ078, CUC18A002-2)
文摘Mobile operators face the challenge of how to best design a service-centric network that can effectively process the rapidly increasing number of bandwidth-intensive user requests while providing a higher quality of experience(QoE). Existing content distribution networks(CDN) and mobile content distribution networks(mCDN) have both latency and throughput limitations due to being multiple network hops away from end-users. Here, we first propose a new Personalized Edge Caching System(PECS) architecture that employs big data analytics and mobile edge caching to provide personalized service access at the edge of the mobile network. Based on the proposed system architecture, the edge caching strategy based on user behavior and trajectory is analyzed. Employing our proposed PECS strategies, we use data mining algorithms to analyze the personalized trajectory and service usage patterns. Our findings provide guidance on how key technologies of PECS can be employed for current and future networks. Finally, we highlight the challenges associated with realizing such a system in 5G and beyond.
基金Apatinib,S-1 combined with paclitaxel perfusion in the treatment of malignant seroperitoneum of gastric cancer(No.of project:17ZF165)。
文摘Objective:To analyze the effect of apatinib,S-1 combined with paclitaxel perfusion on malignant seroperitoneum of gastric cancer.Methods:From December 2019 to May 2020,172 patients with gastric cancer treated in our hospital were randomly divided into two groups:observation group and control group,86 cases each.The control group adopted the method of S-1 combined with paclitaxel perfusion therapy in the treatment of malignant seroperitoneum of gastric cancer.The observation group was given oral apatinib on the basis of S-1 combined with paclitaxel perfusion therapy,and the dosage was 500 mg/d.Results:The total effective treatment in the control group was 43.02%,while the total effective rate in the observation group was 69.77%;the drug resistance of the two groups of patients increased and the adverse reactions were low.Conclusion:Apatinib and S-1 combined with paclitaxel perfusion therapy can effectively improve the treatment effect,stabilize the patient's condition,increase the patient's drug resistance to adverse reactions,and have a good prognosis.
基金Project supported by the National Natural Science Foundation of China (Grant Nos. 21422404,21774092,U1532108,21728502,and U1932121)the Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions+1 种基金the support of the Natural Science Foundation of Jiangsu Province of China (Grant Nos. BK20171207 and BK20171210)the support of Undergraduate Training Program for Innovation and Entrepreneurship of Soochow University,China (Grant No. 201810285023Z)
文摘Lateral heterogeneity of a cell membrane,including the formation of lipid raft-like clusters and the inter-leaflet coupling of specific phase domains,is crucial for cellular functions such as membrane trafficking and transmembrane signaling.However,the wide diversity in lipid species and the consequent complexity in lipid-lipid interplays hinder our understanding of the underlying mechanism.In this work,with coarse-grained molecular dynamics simulations,the effect of lipid tail structures on the phase behavior of a model ternary lipid membrane was systematically explored.A serial of 27 lipid membrane systems consisting of saturated,unsaturated lipids,and cholesterol(Chol)molecules,at a fixed molar ratio of 4:4:2 while varying in lipid structures including tail length,unsaturation degree,and/or position of unsaturated atoms,were constructed.These structural factors were found to exert sophisticated influences on packing states of the constituent molecules,especially Chol,in a bilayer,and modulate the complicated entropy-enthalpy competition of the membrane system accordingly.Specifically,an appropriate difference in effective tail length and distinct feature of the tail ends between the saturated and unsaturated lipid compositions promised an enhanced phase separation of the membrane into the Chol-rich Lo and Chol-poor Ld phase domains,with a full inter-leaflet coupling of each domain.Our results provide insights into the lipid organizations and segregations of the cellular plasma membrane.
基金We are grateful for the financial support of the National Key Research and Development Program of China(2016YFC0503200)the National Nature Science Foundation of China(31570408 and 31801986)the China Postdoctoral Science Foundation(2018M631372).
文摘Habitat restoration is an effective method for improving landscape connectivity,which can reduce habitat fragmentation.Maintaining landscape connectivity could promote connections between habitat,which is extremely essential to preserve gene flow and population viability.This study proposes a methodological framework to analyze landscape connectivity for Asian elephant habitat conservation,aiming to provide practical options for reducing habitat fragmentation and improving habitat connectivity.Our approach involved combining a species distribution model using MaxEnt and landscape functional connectivity models using graph theory to assess the impact on connectivity improvement via farmland/plantation restoration as habitat.The results showed that:(1)there were 119 suitable habitat patches of Asian elephant covering a total area of 1952.41 km^(2).(2)The connectivity between habitats improved significantly after vegetation restoration and the gain first decreased and then increased with the increase of dispersal distance.(3)The first few new habitat patches that were identified played an important role in improving connectivity,and the variation rate of connectivity gradually leveled off as the number of new habitats increased.(4)Prioritization of the 25 best new habitat patches increased connectivity from 0.54%to 5.59%as the dispersal distance increased and mainly was located between two Asian elephant distribution regions and two components.Establishment of new habitat patches was effective for improving or restoring connectivity.Our findings can be used as guidance for improving the studied fragmented Asian elephant habitats,and they can also be used as a reference for the habitat restoration of other endangered species heavily affected by habitat fragmentation.
基金supported by the Key-Area Research and Development Program of Guangdong Province (No.2020B0303020001)the National Natural Science Foundation of China (Nos.62031024 and 12104443)+5 种基金the Innovation Program for Quantum Science and Technology (No.2021ZD0300300)the Shanghai MunicipalScienceandTechnologyMajorProject (No.2019SHZDZX01)the Shanghai Science and Technology Development Foundation (No.22JC1402900)the Shanghai Academic/Technology Research Leader (No.21XD1403800)the Shanghai Sailing Program (No.21YF1452600)the Natural Science Foundation of Shanghai (No.21ZR1470000)。
文摘We proposed a hybrid imaging scheme to estimate a high-resolution absolute depth map from low photon counts. It leverages measurements of photon arrival times from a single-photon LiDAR and an intensity image from a conventional high-resolution camera. Using a tailored fusion algorithm, we jointly processed the raw measurements from both sensors and output a high-resolution absolute depth map. We scaled up the resolution by a factor of 10, achieving 1300 × 2611 pixels and extending ~4.7 times the unambiguous range. These results demonstrated the superior capability of long-range high-resolution 3D imaging without range ambiguity.
基金Supported by the National Natural Science Foundation of China(42275039 and 42022038)。
文摘Atmospheric radiation is a major branch of atmospheric physics that encompasses the fundamental theories of atmospheric absorption,particle scattering(aerosols and clouds),and radiative transfer.Specifically,the simulations of atmospheric gaseous absorption and scattering properties of particles are the essential components of atmospheric radiative transfer models.Atmospheric radiation has important applications in weather,climate,data assimilation,remote sensing,and atmospheric detection studies.In PartⅠ,a comprehensive review of the progress in the field of gas absorption and particle scattering research over the past 30 years with a particular emphasis on the contributions from Chinese scientists is presented.The review of gas absorption includes the construction of absorption databases,the impact of different atmospheric absorption algorithms on radiative calculations,and their applications in weather and climate models and remote sensing.The review on particle scattering starts with the theoretical and computational methods and subsequently explores the optical modeling of aerosols and clouds in remote sensing and atmospheric models.Additionally,the paper discusses potential future research directions in this field.
基金The authors gratefully acknowledge the support of the Enhancement Strategy of Multi-Type Energy Integration of Active Distribution Network(YNKJXM20220113).
文摘In the framework of vigorous promotion of low-carbon power system growth as well as economic globalization,multi-resource penetration in active distribution networks has been advancing fiercely.In particular,distributed generation(DG)based on renewable energy is critical for active distribution network operation enhancement.To comprehensively analyze the accessing impact of DG in distribution networks from various parts,this paper establishes an optimal DG location and sizing planning model based on active power losses,voltage profile,pollution emissions,and the economics of DG costs as well as meteorological conditions.Subsequently,multiobjective particle swarm optimization(MOPSO)is applied to obtain the optimal Pareto front.Besides,for the sake of avoiding the influence of the subjective setting of the weight coefficient,the decisionmethod based on amodified ideal point is applied to execute a Pareto front decision.Finally,simulation tests based on IEEE33 and IEEE69 nodes are designed.The experimental results show thatMOPSO can achieve wider and more uniformPareto front distribution.In the IEEE33 node test system,power loss,and voltage deviation decreased by 52.23%,and 38.89%,respectively,while taking the economy into account.In the IEEE69 test system,the three indexes decreased by 19.67%,and 58.96%,respectively.
基金supported by the National Key Research and Development Program(grant number 2016YFC0501504)the Xinjiang Uygur Autonomous Region Key Research and Development Program(grant number 2016B01005-1)+1 种基金the Xinjiang Uygur Autonomous Region Horticulture Key Discipline Fund(grant number 2016-10758-3)the Xinjiang Uygur Autonomous Region Graduate Innovation Project(grant number XJ2019G134).
文摘Single-nucleotide polymorphisms(SNPs)are the most abundant form of genomic polymorphisms and are widely used in population genetics research.Here,high-throughput sequencing was used to examine the genome-level diversity,population structure,and relationships of apricot,which are important for germplasm conservation and molecular breeding.Restriction site-associated DNA sequencing(RAD-seq)was adopted to sequence 168 Prunus spp.accessions distributed in five ecological groups,including 74 accessions of cultivated Prunus armeniaca L.and 94 accessions of wild apricots(P.armeniaca L.and Prunus sibirica L.),which generated 417,961 high-quality SNPs.We used cluster,genetic structure,and principal component analyses to examine the genetic diversities and genetic relationships of the 168 accessions.The Dzhungar-Ili ecological group accessions showed the highest genetic diversity in terms of private allele number,observed heterozygosity,and nucleotide diversity.We speculate that the Central Asian ecological group accessions were domesticated from the Dzhungar-Ili ecological group accessions.The population structure and gene flow of the North China and European ecological group accessions suggested a genetic background of P.sibirica.We argue that the two groups should be considered hybrid swarms connected to P.sibirica by continuous and extensive gene flow.P.armeniaca originated in Northwest China(Ili Valley),subsequently spread throughout Central Asia,and eventually spread to Europe.In addition,selective sweep signatures in P.armeniaca during domestication from wild to cultivated apricots,combined with differentially expressed genes,underlie distinct fruit traits,including sugars,aromas,organic acids,and carotenoids.This study provides substantive and valuable genomic resources that will significantly advance apricot improvement and effective utilization.
基金supported by the National Natural Science Foundation of China under Grant 71804089the Humanities and Social Sciences Youth Foundation of Ministry of Education of China under Grants 18YJCZH034 and 19YJC790128+3 种基金the Jiangsu Postdoctoral Research Foundation underGrant 2018K195C,the Natural Science Foundation of Shandong Province in China under Grant ZR2020QG054the Graduate Education Quality Improvement Project of Shandong Province,China under Grants SDYKC19180 and SDYAL19180The project number of“The quality course in Financial Statistics”is SDYKC19180The project number of“Financial Literacy Oriented Case Library of Derivative Financial Instruments Teaching”is SDYAL19180.
文摘Bohai Rim region is an important economic development area and a large carbon emission area in China.It is of great significance to explore the total factor energy efficiency and its influencing factors for the low carbon transformation and high-quality development of the Bohai Rim region.Based on the total factor energy efficiency framework,the DDF-DEA model was used to calculate the total factor energy efficiency,and the internal and external differences of the total factor energy efficiency were further analyzed.The internal and external influencing factors were determined by ML index method and classical endogenous growth theory,and then the Tobit panel model was used to empirically analyze the action mechanism of all influencing factors of total factor energy efficiency in the Bohai Rim region.The results show that the pure technical efficiency,scale efficiency and technological progress among the internal influencing factors contribute to the improvement of energy efficiency in the Bohai Rim region.Industrial structure,industrial internal structure and ownership structure inhibit the improvement of energy efficiency.Energy consumption structure and energy endowment also have a negative impact on energy efficiency.Therefore,measures such as promoting technological progress,adjusting economic structure and optimizing energy structure will effectively improve total factor energy efficiency in the Bohai Rim region.
基金supported by the National Natural Science Foundation of China(Nos.21971002 and 42077361)the Natural Science Foundation of Anhui Province(No.1908085QB45)+1 种基金Open Fund of State Key Lab of Pollution Control and Resource Reuse Research,China(No.PCRRF20002)the University Natural Science Research Project of Anhui Province(No.KJ2020A0064).
文摘In heterogeneous catalytic reactions,supported metal catalysts have attracted increasing attention for the environmental remediation and industrial manufacture due to their inherent catalytic capacity.However,leaching,agglomeration,and poisoning of active metal particles lead to catalyst deactivation,thereby limiting their applications.To avoid this,strategies to protect the active metals from such inactivating processes are major areas of research.Emerging encapsulation strategies,in which active species are coated by protective shells,have proven to be a powerful technology to enhance catalytic performance by creating a well-developed structure about the active catalytic sites.This review highlights the recent advances on preparation method and application of encapsulated catalysts since 2016.Building upon the traditional confinement effect,new categories and extended concepts of encapsulation are introduced.In parallel,effects of encapsulation structure on performance and key factors controlling the structure of encapsulated catalyst are discussed definitely in this review.Finally,future perspectives on opportunities and challenges for further research in the field are given at the end of this paper.
基金This project was funded by National Key R&D Program of China(2018YFA0800701,2018YFA0507603,and 2018YFA0800501)National Natural Science Foundation of China(81770376,81630008,81790621,31521062,31671177,and 81370234)+1 种基金Beijing Natural Science Foundation(5182010)Beijing Municipal Science&Technology Commission(Z171100000417006).
文摘Due to the essential role of cyclin D1 in regulating transition from G1 to S phase in cell cycle,aberrant cyclin D1 expression is a major oncogenic event in many types of cancers.In particular,the dysregulation of ubiquitination-dependent degradation of cyclin D1 contributes to not only the pathogenesis of malignancies but also the refractory to cancer treatment regiments with CDK4/6 inhibitors.Here we show that in colorectal and gastric cancer patients,MG53 is downregulated in more than 80%of tumors compared to the normal gastrointestinal tissues from the same patient,and the reduced MG53 expression is correlated with increased cyclin D1 abundance and inferior survival.Mechanistically,MG53 catalyzes the K48-linked ubiquitination and subsequent degradation of cyclin D1.Thus,increased expression of MG53 leads to cell cycle arrest at G1,and thereby markedly suppresses cancer cell proliferation in vitro as well as tumor growth in mice with xenograft tumors or AOM/DSS induced-colorectal cancer.Consistently,MG53 deficiency results in accumulation of cyclin D1 protein and accelerates cancer cell growth both in culture and in animal models.These findings define MG53 as a tumor suppressor via facilitating cyclin D1 degradation,highlighting the therapeutic potential of targeting MG53 in treating cancers with dysregulated cyclin D1 turnover.