Clinical Effects of Moxifloxacin and Levofloxacin in the Treatment of Elderly Patients with Community-Acquired Pneumonia

Objective:To compare the clinical efficacy of moxifloxacin and levofloxacin in the treatment of elderly patients with community-acquired pneumonia(CAP).Methods:A total of 80 elderly CAP patients admitted between April 2023 and February 2024 were randomly divided into two groups.The control group(n=40)received treatment with levofloxacin,while the observation group(n=40)was treated with moxifloxacin.Relevant clinical indicators were observed and compared between the two groups.Results:The overall effective treatment rate in the observation group reached 95.00%,significantly higher than the 75.00%observed in the control group(P<0.05).The time required for improvement in clinical symptoms was significantly shorter in the observation group compared to the control group(P<0.001).Pulmonary function indicators,including FVC,FEV1,and FEV1/FVC,improved in both groups after treatment,but the improvement was more pronounced in the observation group(P<0.001).Serum inflammatory factor levels indicated that post-treatment levels of IL-6,PCT,and CRP decreased in both groups compared to pre-treatment levels,with a more significant reduction in the observation group(P<0.001).The incidence of adverse reactions in the observation group was 7.50%,markedly lower than the 25.00%observed in the control group(P<0.05).Conclusion:Moxifloxacin demonstrates better clinical efficacy and safety in the treatment of elderly patients with CAP,making it a valuable option for clinical application.However,the choice of medication should still consider individual patient conditions comprehensively.

A new trick on an old support: Zr in situ defects-created carbon nitride for efficient electrochemical nitrogen fixation

Electrochemical nitrogen reduction reaction(NRR) to produce ammonia under ambient conditions is considered as a promising approach to tackle the energy-intensive Haber-Bosch process,but the low Faradaic efficiency and yield of NH_3 are still a challenge.Herein,a carbon-vacancies enriched mesoporous g-C_3 N_4 is developed by an in situ Zr doping strategy.The in situ mesoporous-forming mechanism is deeply understood by TPSR to reveal the functions of Zr dopant that pulls C from the precursor of C_3 N_4,resulting the formation of homogeneous mesopores with about 57% of the one C-defective s-triazine ring in C_3 N_4.Due to the defect sites obtained in metal doping synthesis,the RuAu bimetallic supported catalyst(RuAu_3/0.3 Zr-C_3 N_4) exhibits effective NRR performance with a Faraday efficiency of 11.54% and an NH_3 yield of 5.28 μg h^(-1) mg_(cat) ^(-1).at-0.1 V(RHE),which is nearly 10 times higher than that of RuAu_3/C_3 N_4 catalyst.This work proposes a simple and template-free preparation method for the high defect density mesoporous C_3 N_4,and provides new possibilities of a wide application of mesopore g-C3 N4.

Research progress in ZnO single-crystal:growth, scientific understanding, and device applications

Zinc oxide,a wide band-gap semiconductor,has shown extensive potential applications in high-efficiency semiconductor photoelectronic devices,semiconductor photocatalysis,and diluted magnetic semiconductors.Due to the undisputed lattice integrity,ZnO single crystals are essential for the fabrication of high-quality ZnO-based photoelectronic devices,and also believed to be ideal research subjects for understanding the underlying mechanisms of semiconductor photocatalysis and diluted magnetic semiconductors.This review,which is organized in two main parts,introduces the recent progress in growth,basic characterization,and device development of ZnO single crystals,and some related works in our group.The first part begins from the growth of ZnO single crystal,and summarizes the fundamental and applied investigations based on ZnO single crystals.These works are composed of the fabrication of homoepitaxial ZnO-based photoelectronic devices,the research on the photocatalysis mechanism,and dilute magnetic mechanism.The second part describes the fabrication of highly thermostable n-type ZnO with high mobility and high electron concentration through intentional doping.More importantly,in this part,a conceptual approach for fabricating highly thermostable p-type ZnO materials with high mobility through an integrated three-step treatment is proposed on the basis of the preliminary research.