The flowers of the hemiparasitic family Loranthaceae are always subtended by a rimmed structure known as the calyculus.The origin and identity of the calyculus have been disputed for more than a century.Various hypoth...The flowers of the hemiparasitic family Loranthaceae are always subtended by a rimmed structure known as the calyculus.The origin and identity of the calyculus have been disputed for more than a century.Various hypotheses have been proposed,for example,an outgrowth of the axis,a reduced calyx,and a bracteolar(prophyllar)origin,but controversies remain.To obtain a plausible explanation of the origin of the calyculus,we investigated the flowers of Loranthus tanakae using scanning electron microscopy and light microscopy to observe the entire developmental process of the floral parts.Our results show that bracts are not present in L.tanakae.The calyculus,which lacks serving vascular bundles,initiates as a semicircular primordium and then develops into a circular structure by an adnation at both sides.The flower primordium usually cleaves into six petals from its centre along a whorled pattern in two series with three petals each,before or after the calyculus closed.Isomerous stamen primordia probably follow the same initiation pattern as petals do.Several carpels of different sizes initiate simultaneously as a united primordium.We support the hypotheses that the calyculus is of bract or bracteole origin due to its independent initiation from the inflorescence rachis,its similar morphology and positioning as the bract or bracteole,and that having no developmental relationship with the petals.We suggest keeping the usage of the term“calyculus”.Loranthus flowers should be considered monochlamydeous with three whorls of floral parts,namely petal,androecium,and gynoecium.展开更多
Pancreatic adenocarcinoma(PAAD) is one of the most lethal malignancies. Although gemcitabine(GEM) is a standard treatment for PAAD, resistance limits its application and therapy. Secoemestrin C(Sec C) is a natural com...Pancreatic adenocarcinoma(PAAD) is one of the most lethal malignancies. Although gemcitabine(GEM) is a standard treatment for PAAD, resistance limits its application and therapy. Secoemestrin C(Sec C) is a natural compound from the endophytic fungus Emericella, and its anticancer activity has not been investigated since it was isolated. Our research is the first to indicate that Sec C is a broad-spectrum anticancer agent and could exhibit potently similar anticancer activity both in GEM-resistant and GEM-sensitive PAAD cells. Interestingly, Sec C exerted a rapid growth-inhibiting effect(80% death at 6 h), which might be beneficial for patients who need rapid tumor shrinkage before surgery. Liquid chromatography/mass spectrometry and N-acetyl-L-cysteine(NAC) reverse assays show that Sec C sulfates cysteines to disrupt disulfide-bonds formation in endoplasmic reticulum(ER) proteins to cause protein misfolding, leading to ER stress and disorder of lipid biosynthesis. Microarray data and subsequent assays show that ER stress-mediated ER-associated degradation(ERAD) ubiquitinates anddownregulates YAP to enhance ER stress via destruction complex(YAP-Axin-GSK-βTr CP), which also elucidates a unique degrading style for YAP. Potent anticancer activity in GEM-resistant cells and low toxicity make Sec C a promising anti-PAAD candidate.展开更多
Ni-rich oxides,LiNixMnyCozO2(NMC),are among leading candidates for cathode materials in Li-ion batteries.However,they are mostly fabricated by coprecipitation approach under complex conditions,which usually produces l...Ni-rich oxides,LiNixMnyCozO2(NMC),are among leading candidates for cathode materials in Li-ion batteries.However,they are mostly fabricated by coprecipitation approach under complex conditions,which usually produces large secondary particles composed of aggregated primary particles.Undesirable cation mixing and crack propagation upon cycling block ion and electron transport,result in fast capacity fading and poor rate capability.Herein,we present an ultrasound-triggered cation chelation and reassembly route for synthesizing one-dimensional precursor with homogeneous element distribution at the atomic level.This process is accomplished by the synergistic combination of ultrasound and surfactant,which can disperse reactants and remove hydration shells surrounding cations so as to accelerate chelating reaction,and then separate and assemble chelates into one dimensional structure.The whole synthesis time is only 20 min(8.9 min of ultrasonic working time)in an open vessel under natural ambient conditions.One-dimensional LiNi0.6Mn0.2Co0.2O2 has a high reversible capacity(184 mAh·g^−1 at 0.1 C)and long cycling stability(95.1%and 82.4%capacity retention for 100 and 1000 cycles,respectively).The short charging time of 76 s is realized at super high current rate of 20 C,which is very important to improve the competitiveness of electric vehicles relative to fuel vehicles.Our synthetic approach can provide a general strategy for the growth of mixed-metal-EDTA chelate precursors by changing the feeding ratio of Ni2+,Mn2+and Co2+cations in reaction for fabricating NMC cathode materials with other compositions.展开更多
基金by the Program for Integrated Traditional Chinese and Western Medicine in Shandong Province of China(YXH2019ZXY007)Ji’nan Professionals Development Special Fund(20228118)+1 种基金Science and Technology Project of(Sinopec Group)Shengli Petroleum Administration Co.,Ltd(GKY2001)Science and Technology Project of Ji'nan Health Committee(2020-3-65).
基金funded by the National Key R&D Program of China(2016YFC0501503)the Fundamental ResearchFunds for theCentral Non-profit Research Instituteof theCAF(CAFYBB2017SZ003).
基金This research was financially supported by the National Natural Science Foundation of China(No.31400520)Central Public-interest Scientific Institution Basal Research Funds(Nos.CAFYBB2014QB032,CAFRIFEEP2015B09).
文摘The flowers of the hemiparasitic family Loranthaceae are always subtended by a rimmed structure known as the calyculus.The origin and identity of the calyculus have been disputed for more than a century.Various hypotheses have been proposed,for example,an outgrowth of the axis,a reduced calyx,and a bracteolar(prophyllar)origin,but controversies remain.To obtain a plausible explanation of the origin of the calyculus,we investigated the flowers of Loranthus tanakae using scanning electron microscopy and light microscopy to observe the entire developmental process of the floral parts.Our results show that bracts are not present in L.tanakae.The calyculus,which lacks serving vascular bundles,initiates as a semicircular primordium and then develops into a circular structure by an adnation at both sides.The flower primordium usually cleaves into six petals from its centre along a whorled pattern in two series with three petals each,before or after the calyculus closed.Isomerous stamen primordia probably follow the same initiation pattern as petals do.Several carpels of different sizes initiate simultaneously as a united primordium.We support the hypotheses that the calyculus is of bract or bracteole origin due to its independent initiation from the inflorescence rachis,its similar morphology and positioning as the bract or bracteole,and that having no developmental relationship with the petals.We suggest keeping the usage of the term“calyculus”.Loranthus flowers should be considered monochlamydeous with three whorls of floral parts,namely petal,androecium,and gynoecium.
基金supported by the National Key Research and Development Program of China(2016YFA0201504)National Natural Science Foundation of China(No.81473249 and81102464)+2 种基金the National Mega-project for Innovative Drugs(2014ZX09201042,China)the CAMS Innovation Fund for Medical Sciences(CIFMS,2016-I2M-2-002,China)Drug Innovation Major Project of China(2018ZX09711001-007-002)。
文摘Pancreatic adenocarcinoma(PAAD) is one of the most lethal malignancies. Although gemcitabine(GEM) is a standard treatment for PAAD, resistance limits its application and therapy. Secoemestrin C(Sec C) is a natural compound from the endophytic fungus Emericella, and its anticancer activity has not been investigated since it was isolated. Our research is the first to indicate that Sec C is a broad-spectrum anticancer agent and could exhibit potently similar anticancer activity both in GEM-resistant and GEM-sensitive PAAD cells. Interestingly, Sec C exerted a rapid growth-inhibiting effect(80% death at 6 h), which might be beneficial for patients who need rapid tumor shrinkage before surgery. Liquid chromatography/mass spectrometry and N-acetyl-L-cysteine(NAC) reverse assays show that Sec C sulfates cysteines to disrupt disulfide-bonds formation in endoplasmic reticulum(ER) proteins to cause protein misfolding, leading to ER stress and disorder of lipid biosynthesis. Microarray data and subsequent assays show that ER stress-mediated ER-associated degradation(ERAD) ubiquitinates anddownregulates YAP to enhance ER stress via destruction complex(YAP-Axin-GSK-βTr CP), which also elucidates a unique degrading style for YAP. Potent anticancer activity in GEM-resistant cells and low toxicity make Sec C a promising anti-PAAD candidate.
基金This work was financially supported by the National Natural Science Foundation of China(No.51772337)Free Exploration Fund of State Key Laboratory of Optoelectronic Materials and Technologies of China(No.OEMT-2017-ZY-09).
文摘Ni-rich oxides,LiNixMnyCozO2(NMC),are among leading candidates for cathode materials in Li-ion batteries.However,they are mostly fabricated by coprecipitation approach under complex conditions,which usually produces large secondary particles composed of aggregated primary particles.Undesirable cation mixing and crack propagation upon cycling block ion and electron transport,result in fast capacity fading and poor rate capability.Herein,we present an ultrasound-triggered cation chelation and reassembly route for synthesizing one-dimensional precursor with homogeneous element distribution at the atomic level.This process is accomplished by the synergistic combination of ultrasound and surfactant,which can disperse reactants and remove hydration shells surrounding cations so as to accelerate chelating reaction,and then separate and assemble chelates into one dimensional structure.The whole synthesis time is only 20 min(8.9 min of ultrasonic working time)in an open vessel under natural ambient conditions.One-dimensional LiNi0.6Mn0.2Co0.2O2 has a high reversible capacity(184 mAh·g^−1 at 0.1 C)and long cycling stability(95.1%and 82.4%capacity retention for 100 and 1000 cycles,respectively).The short charging time of 76 s is realized at super high current rate of 20 C,which is very important to improve the competitiveness of electric vehicles relative to fuel vehicles.Our synthetic approach can provide a general strategy for the growth of mixed-metal-EDTA chelate precursors by changing the feeding ratio of Ni2+,Mn2+and Co2+cations in reaction for fabricating NMC cathode materials with other compositions.
