As a promising cancer treatment method,cold atmospheric plasma has received widespread attention in recent years.However,previous research has focused more on how to realize and expand the anti-cancer scope of plasma ...As a promising cancer treatment method,cold atmospheric plasma has received widespread attention in recent years.However,previous research has focused more on how to realize and expand the anti-cancer scope of plasma jet.There are also studies on the killing of small-scale cancer cells,but the effects of plasma jet on normal cells and normal cell clusters have been ignored.Therefore,we proposed a 50μm sized micro-plasma jet device,and used the device to treat melanoma cells(A-375)and human glial cells(HA1800)to evaluate their anti-cancer effects and effects on normal cells.The experimental results show that this kind of micro-plasma jet device can effectively inactivate cancer cells in a short period of time,while having little effect on normal cells.This work provides a certain experimental basis for the application offine plasma jet to clinically inactivate cancer cells.展开更多
By tilting a plasma jet and rotating 360°,a large-area can be scanned and sterilized in a short time.Compared with the previous array device,this pipe has the significant advantages of high sterilization uniformi...By tilting a plasma jet and rotating 360°,a large-area can be scanned and sterilized in a short time.Compared with the previous array device,this pipe has the significant advantages of high sterilization uniformity and low gas consumption.Firstly,a rotatable plasma jet device,which can control the swing and rotation of a jet pipe,is designed,and a corresponding theoretical model is established to guide the experiment.Secondly,with Staphylococcus aureus(S.aureus)and Escherichia coli(E.coli)as the target bacteria,the device achieves a short sterilization time of 158 s—the minimum sterilization flow of S.aureus and E.coli is 0.8 slm and 0.6 slm,respectively.The device is compared with an array plasma sterilization device in terms of sterilization speed and gas consumption.The results show that the device is not only better than an array plasma sterilization device with respect to scanning uniformity,but also far less than the array plasma sterilization device in gas consumption of 5 slm.Therefore,the device has great potential in applications involving efficient,large-area sterilization.展开更多
基金supported by the National Natural Science Foundation of China under Grant Number 62163009 and 61864001the Natural Science Foundation of GuangXi under Grant Number 2021JJD170019+2 种基金the Foundation of Guangxi Key Laboratory of Automatic Detecting Technology and Instruments(Guilin University of Electronic Technology)under Grant Number YQ23103Innovation Project of GuangXi Graduate Education under Grant Nos.YCSW2022277 and 2023YCXS184Guangxi Major Scientific and Technological Innovation Base(Guilin University of Electronic Technology)under Grant 231002-k.
文摘As a promising cancer treatment method,cold atmospheric plasma has received widespread attention in recent years.However,previous research has focused more on how to realize and expand the anti-cancer scope of plasma jet.There are also studies on the killing of small-scale cancer cells,but the effects of plasma jet on normal cells and normal cell clusters have been ignored.Therefore,we proposed a 50μm sized micro-plasma jet device,and used the device to treat melanoma cells(A-375)and human glial cells(HA1800)to evaluate their anti-cancer effects and effects on normal cells.The experimental results show that this kind of micro-plasma jet device can effectively inactivate cancer cells in a short period of time,while having little effect on normal cells.This work provides a certain experimental basis for the application offine plasma jet to clinically inactivate cancer cells.
基金partially supported by National Natural Science Foundation of China(Nos.61864001 and 62163009)Key Projects of Guangxi Natural Science Foundation(No.2021JJD170019)+1 种基金the Foundation of Guangxi Key Laboratory of Automatic Detecting Technology and Instruments(Guilin University of Electronic Technology)(Nos.YQ21111 and YQ21204)Innovation Project of Guang Xi Graduate Education(No.YCSW2021181)。
文摘By tilting a plasma jet and rotating 360°,a large-area can be scanned and sterilized in a short time.Compared with the previous array device,this pipe has the significant advantages of high sterilization uniformity and low gas consumption.Firstly,a rotatable plasma jet device,which can control the swing and rotation of a jet pipe,is designed,and a corresponding theoretical model is established to guide the experiment.Secondly,with Staphylococcus aureus(S.aureus)and Escherichia coli(E.coli)as the target bacteria,the device achieves a short sterilization time of 158 s—the minimum sterilization flow of S.aureus and E.coli is 0.8 slm and 0.6 slm,respectively.The device is compared with an array plasma sterilization device in terms of sterilization speed and gas consumption.The results show that the device is not only better than an array plasma sterilization device with respect to scanning uniformity,but also far less than the array plasma sterilization device in gas consumption of 5 slm.Therefore,the device has great potential in applications involving efficient,large-area sterilization.
