Titanium dioxide with CoB amorphous alloys nanoparticles deposited on the surface is known to exhibit higher catalytic activity than the CoB amorphous.A study of the structure of such system is necessary to understand...Titanium dioxide with CoB amorphous alloys nanoparticles deposited on the surface is known to exhibit higher catalytic activity than the CoB amorphous.A study of the structure of such system is necessary to understand this effect.A quantum chemical study of Co2B2 on the TiO2（110） surface was studied using periodic slab model within the framework of density functional theory（DFT）.The results of geometry optimization indicated that the most stable model of adsorption was Co2B2 cluster adsorbed on the hollow site of TiO2 .The adsorption energy calculated for Co2B2 on the hollow site was 439.3 kJ/mol.The adsorption of CO and O2 was further studied and the results indicated that CO and O2 are preferred to adsorb on the Co2 site.Co-adsorption of CO and O2 shows that Co2B2 /TiO2 is a good catalyst for the oxidation of CO to carbon dioxide in the presence of oxygen.展开更多
[Objectives]To explore the inhibitory effect of AURKB gene in apoptosis and cancer cell growth in HCT 116 cells.[Methods]The in vitro cytology studies were carried out to confirm the expression of the AURKB gene in HC...[Objectives]To explore the inhibitory effect of AURKB gene in apoptosis and cancer cell growth in HCT 116 cells.[Methods]The in vitro cytology studies were carried out to confirm the expression of the AURKB gene in HCT 116 cells and make clear its role in cell activity,cell cycle control and apoptosis,and investigate the effect of AURKB gene in colorectal cancer(CRC).Quantitative reverse transcription/polymerase chain reaction(PCR)analysis and immunofluorescence(IF)staining for markers of AURKB gene were used to examine the effect of AURKB on HCT 116.The AURKB gene target was examined using western blot analysis.In addition,inhibition of AURKB expression was examined using RNA interference(RNAi)on HCT 116 cells in vitro.[Results]HCT 116 cells infected with AURKB shRNA virus suppressed expression of AURKB in vitro.AURKB gene knockdown HCT 116 cells showed reducing cell apoptosis in vitro.Finally,it demonstrated that AURKB function can induce apoptosis of HCT cells.[Conclusions]AURKB is a key regulator of colorectal cancer.AURKs are potential novel molecular targets for the prevention of cancer cell proliferation.展开更多
Via an insufficient coat protein complex I(COPI)retrieval signal,the majority of SARSCo V-2 spike(S)is resident in host early secretory organelles and a tiny amount is leaked out in cell surface.Only surface-exposed S...Via an insufficient coat protein complex I(COPI)retrieval signal,the majority of SARSCo V-2 spike(S)is resident in host early secretory organelles and a tiny amount is leaked out in cell surface.Only surface-exposed S can be recognized by B cell receptor(BCR)or anti-S therapeutic monoclonal antibodies(m Abs)that is the trigger step for B cell activation after S m RNA vaccination or infected cell clearance by S m Abs.Now,a drug strategy to promote S host surface exposure is absent.Here,we first combined structural and biochemical analysis to characterize S COPI sorting signals.A potent S COPI sorting inhibitor was then invented,evidently capable of promoting S surface exposure and facilitating infected cell clearance by S antibody-dependent cellular cytotoxicity(ADCC).Importantly,with the inhibitor as a probe,we revealed Omicron BA.1 S is less cell surface exposed than prototypes because of a constellation of S folding mutations,possibly corresponding to its ER chaperone association.Our findings not only suggest COPI is a druggable target against COVID-19,but also highlight SARS-Co V-2 evolution mechanism driven by S folding and trafficking mutations.展开更多
The design of the photocatalytic materials has made a great of remarkable progress in the area of the enhancement photocatalytic activity,but there are still lots of problems such as wide band gap,low utilization of s...The design of the photocatalytic materials has made a great of remarkable progress in the area of the enhancement photocatalytic activity,but there are still lots of problems such as wide band gap,low utilization of sunlight,low quantum efficiency and poor stability,which further limit the extensive practical applications.Thus,it is a hot research topic and key scientific problem to be solved that how to design and prepare the catalysts,which can respond to visible and near-infrared light in sunlight.Inspired by efficient nonlinear optical upconversion materials,upconversion-based nanocomposites can indirectly broaden the absorption ranges of semiconductors by co nverting the captured long-band visible and near-infrared incident light into high-energy short-band visible or ultraviolet light,which can be adopted as the promising candidate in wide-spectral-light-activating photocatalytic materials coupling with conventional semiconductors.According to our recent works and literature reports,recent review summarizes the research progress of photocatalytic materials with upconversion effect on photolysis of water for hydrogen production,degradation of organic and inorganic pollutants,reduction of CO_(2) and photodynamic therapy.The prepared nanocomposites can suppress the recombination of electrons and holes,and greatly improve the photocatalytic efficiency by the synergistic effect.It maybe stimulates a great interest in rational design and preparation of efficient full-spectrum photocatalytic systems and their wide application in solar energy conversion.展开更多
The utilization of photoelectrochemical cathodic protection(PECCP)enables an indirect corrosion pro-tection of metals with low self-corrosion potential by introducing a metallic nickel interlayer.However,the ability t...The utilization of photoelectrochemical cathodic protection(PECCP)enables an indirect corrosion pro-tection of metals with low self-corrosion potential by introducing a metallic nickel interlayer.However,the ability to enhance the PECCP efficiency remains challenging because of the inherent property of the semiconductor.Herein,this ability is demonstrated by coupling a covalent organic framework(TpBD)dec-orated TiO 2 photoanode(TiO 2/TpBD)with nickel coating on magnesium alloy for an effective corrosion protection.The composite photoanode showed direct PECCP for the nickel interlayer and indirect corro-sion protection of the magnesium alloy.The composite structure of the nanotube array and the covalent organic framework for the photoanode were confirmed by field emission scanning electron microscopy(FESEM),transmission electron microscopy(TEM),and X-ray photoelectron spectroscopy(XPS).The en-hanced photoelectrochemical conversion capability and PECCP performance of the nickel-coated Mg alloy were evidenced by the results from electrochemical and photoelectrochemical measurements including Mott-Schottky curves,photoinduced potential variations,and electrochemical impedance spectroscopy(EIS).Lastly,a corrosion protection mechanism is proposed,where the enhanced PECCP efficiency is at-tributed to the formation of a direct Z-scheme heterojunction,which is substantiated by the results from valence band(VB)XPS and electron spin resonance characterizations.展开更多
基金supported by the program for the National Natural Science Foundation of China (90922022, 10676007, and 20773025)NCETFJ (No.HX2006-103)+1 种基金Science and Technology Foundation of Fujian Education Bureau (No. JA08019)Foundation of State Key Laboratory of Coal Combustion(No. FSKLCC0814)
文摘Titanium dioxide with CoB amorphous alloys nanoparticles deposited on the surface is known to exhibit higher catalytic activity than the CoB amorphous.A study of the structure of such system is necessary to understand this effect.A quantum chemical study of Co2B2 on the TiO2（110） surface was studied using periodic slab model within the framework of density functional theory（DFT）.The results of geometry optimization indicated that the most stable model of adsorption was Co2B2 cluster adsorbed on the hollow site of TiO2 .The adsorption energy calculated for Co2B2 on the hollow site was 439.3 kJ/mol.The adsorption of CO and O2 was further studied and the results indicated that CO and O2 are preferred to adsorb on the Co2 site.Co-adsorption of CO and O2 shows that Co2B2 /TiO2 is a good catalyst for the oxidation of CO to carbon dioxide in the presence of oxygen.
文摘[Objectives]To explore the inhibitory effect of AURKB gene in apoptosis and cancer cell growth in HCT 116 cells.[Methods]The in vitro cytology studies were carried out to confirm the expression of the AURKB gene in HCT 116 cells and make clear its role in cell activity,cell cycle control and apoptosis,and investigate the effect of AURKB gene in colorectal cancer(CRC).Quantitative reverse transcription/polymerase chain reaction(PCR)analysis and immunofluorescence(IF)staining for markers of AURKB gene were used to examine the effect of AURKB on HCT 116.The AURKB gene target was examined using western blot analysis.In addition,inhibition of AURKB expression was examined using RNA interference(RNAi)on HCT 116 cells in vitro.[Results]HCT 116 cells infected with AURKB shRNA virus suppressed expression of AURKB in vitro.AURKB gene knockdown HCT 116 cells showed reducing cell apoptosis in vitro.Finally,it demonstrated that AURKB function can induce apoptosis of HCT cells.[Conclusions]AURKB is a key regulator of colorectal cancer.AURKs are potential novel molecular targets for the prevention of cancer cell proliferation.
基金supported by Startup fund program at Beijing University of Chinese Medicine(BUCM)(90011451310011,China)to Wenfu Mathe emergency fund against COVID-19 program at BUCM(1000061223476,China)to Wenfu Mathe innovation team and talents cultivation program of national administration of traditional Chinese medicine(ZYYCXTD-C202006,China)to Wenfu Ma。
文摘Via an insufficient coat protein complex I(COPI)retrieval signal,the majority of SARSCo V-2 spike(S)is resident in host early secretory organelles and a tiny amount is leaked out in cell surface.Only surface-exposed S can be recognized by B cell receptor(BCR)or anti-S therapeutic monoclonal antibodies(m Abs)that is the trigger step for B cell activation after S m RNA vaccination or infected cell clearance by S m Abs.Now,a drug strategy to promote S host surface exposure is absent.Here,we first combined structural and biochemical analysis to characterize S COPI sorting signals.A potent S COPI sorting inhibitor was then invented,evidently capable of promoting S surface exposure and facilitating infected cell clearance by S antibody-dependent cellular cytotoxicity(ADCC).Importantly,with the inhibitor as a probe,we revealed Omicron BA.1 S is less cell surface exposed than prototypes because of a constellation of S folding mutations,possibly corresponding to its ER chaperone association.Our findings not only suggest COPI is a druggable target against COVID-19,but also highlight SARS-Co V-2 evolution mechanism driven by S folding and trafficking mutations.
基金Project supported by the National Natural Science Foundation of China(21962006,21707055,21872030)Youth Key Project of Jiangxi Province Natural Science Foundation(20192ACBL21011)+6 种基金Program of Qingjiang Excellent Young Talents of Jiangxi University of Science and Technology(3401223429)Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme(2019)Guangdong Basic and Applied Basic Research Foundation(2019A1515011249)Key Research Project of Natural Science of Guangdong Provincial Department of Education(2019)Jiangxi Province Natural Science Foundation(20181BAB213010)Open Fund of Guangdong Provincial Key Laboratory of Petrochemical Pollution Process and Control(2018B030322017)Open Fund for Key Laboratory of Green Energy and Environmental Catalysis in Universities of Fujian Province(FJ-GEEC201901)。
文摘The design of the photocatalytic materials has made a great of remarkable progress in the area of the enhancement photocatalytic activity,but there are still lots of problems such as wide band gap,low utilization of sunlight,low quantum efficiency and poor stability,which further limit the extensive practical applications.Thus,it is a hot research topic and key scientific problem to be solved that how to design and prepare the catalysts,which can respond to visible and near-infrared light in sunlight.Inspired by efficient nonlinear optical upconversion materials,upconversion-based nanocomposites can indirectly broaden the absorption ranges of semiconductors by co nverting the captured long-band visible and near-infrared incident light into high-energy short-band visible or ultraviolet light,which can be adopted as the promising candidate in wide-spectral-light-activating photocatalytic materials coupling with conventional semiconductors.According to our recent works and literature reports,recent review summarizes the research progress of photocatalytic materials with upconversion effect on photolysis of water for hydrogen production,degradation of organic and inorganic pollutants,reduction of CO_(2) and photodynamic therapy.The prepared nanocomposites can suppress the recombination of electrons and holes,and greatly improve the photocatalytic efficiency by the synergistic effect.It maybe stimulates a great interest in rational design and preparation of efficient full-spectrum photocatalytic systems and their wide application in solar energy conversion.
基金supported by the Science and Technology Department of Sichuan Province(No.2021ZYD0049)the Natural Science Foundation of Hunan Province(No.2021JJ30543)+2 种基金Open Project Program of the State Key Laboratory of Photocatalysis on Energy and Environment(No.SKLPEE-KF201811),Fuzhou UniversityOpen Project of Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province(No.CSPC202004)the Funda-mental Research Funds of CWNU(No.CXTD2020-1).C.J.Zhong ac-knowledges the support from the National Science Foundation(No.CHE 2102482).Support from the high-level full-time talents pro-gram of Guangdong Provincial People’s Hospital(No.KY012021462)is also acknowledged.
文摘The utilization of photoelectrochemical cathodic protection(PECCP)enables an indirect corrosion pro-tection of metals with low self-corrosion potential by introducing a metallic nickel interlayer.However,the ability to enhance the PECCP efficiency remains challenging because of the inherent property of the semiconductor.Herein,this ability is demonstrated by coupling a covalent organic framework(TpBD)dec-orated TiO 2 photoanode(TiO 2/TpBD)with nickel coating on magnesium alloy for an effective corrosion protection.The composite photoanode showed direct PECCP for the nickel interlayer and indirect corro-sion protection of the magnesium alloy.The composite structure of the nanotube array and the covalent organic framework for the photoanode were confirmed by field emission scanning electron microscopy(FESEM),transmission electron microscopy(TEM),and X-ray photoelectron spectroscopy(XPS).The en-hanced photoelectrochemical conversion capability and PECCP performance of the nickel-coated Mg alloy were evidenced by the results from electrochemical and photoelectrochemical measurements including Mott-Schottky curves,photoinduced potential variations,and electrochemical impedance spectroscopy(EIS).Lastly,a corrosion protection mechanism is proposed,where the enhanced PECCP efficiency is at-tributed to the formation of a direct Z-scheme heterojunction,which is substantiated by the results from valence band(VB)XPS and electron spin resonance characterizations.
