盆腔腹膜后肿瘤临床病例分析

目的:探讨盆腔腹膜后肿瘤(primary pelvic retroperitoneal tumor,PPRT)的诊疗及预后。方法:回顾性分析2000年10月至2021年5月于天津医科大学肿瘤医院诊治的31例PPRT患者的临床病理资料。结果:术前31例患者均行MRI或CT检查,7例提示肿物位于腹膜后,1例因肿物体积大且血管丰富,术前行超声引导下肿物穿刺确诊为肉瘤。31例患者均行手术治疗,其中良性肿瘤15例、恶性肿瘤16例。良性肿瘤以畸胎瘤(5/15)及神经鞘瘤(3/15)多见,良性肿瘤均完整切除;恶性肿瘤以肉瘤(9/16)多见,11例完整切除、5例姑息切除。胚胎残留组织来源的肿瘤均位于正中部位且良性多为囊性,间叶组织及神经组织来源肿瘤多位于侧位且多数具有实性成分。良性肿瘤患者的平均年龄为42.1岁,恶性肿瘤的为49.7岁。随访期内,15例良性肿瘤中14例未复发,1例复发后完整切除;16例恶性肿瘤中4例失访,4例死于该病,2例发生2次复发(2例均行手术),6例未复发。结论:PPRT易漏诊或误诊,鉴别诊断需结合临床特点、妇科检查及影像学检查。超声引导下肿物穿刺有利于在术前制定治疗方案,首选彻底手术切除方法。

Genetic dissection of N use efficiency using maize inbred lines and testcrosses

Although the use of heterosis in maize breeding has increased crop productivity,the genetic causes underlying heterosis for nitrogen(N) use efficiency(NUE) have been insufficiently investigated.In this study,five N-response traits and five low-N-tolerance traits were investigated using two inbred line populations(ILs) consisting of recombinant inbred lines(RIL) and advanced backcross(ABL) populations,derived from crossing Ye478 with Wu312.Both populations were crossed with P178 to construct two testcross populations.IL populations,their testcross populations,and the midparent heterosis(MPH)for NUE were investigated.Kernel weight,kernel number,and kernel number per row were sensitive to N level and ILs showed higher N response than did the testcross populations.Based on a highdensity linkage map,138 quantitative trait loci(QTL) were mapped,each explaining 5.6%–38.8% of genetic variation.There were 52,34 and 52 QTL for IL populations,MPH,and testcross populations,respectively.The finding that 7.6% of QTL were common to the ILs and their testcross populations and that 11.7% were common to the MPH and testcross population indicated that heterosis for NUE traits was regulated by non-additive and non-dominant loci.A QTL on chromosome 5 explained 27% of genetic variation in all of the traits and Gln1-3 was identified as a candidate gene for this QTL.Genome-wide prediction of NUE traits in the testcross populations showed 14%–51% accuracy.Our results may be useful for clarifying the genetic basis of heterosis for NUE traits and the candidate gene may be used for genetic improvement of maize NUE.

A case of pulmonary mucormycosis presented with cardiac arrest

Mucormycosis is an uncommon and opportunistic fungal infection with high mortality. Infections may result from ingestion of contaminated food, inhalation of spores into the respiratory tract or inoculation into disruptedskin.^([1])Pulmonarymucormycosis(PM)is the most common clinical type.

LncRNA PVT1 promotes ovarian cancer progression by silencing miR-214

Objective: Emerging evidence indicates that long non-coding RNAs(lnc RNAs) are critical in carcinogenesis and progression of ovarian cancer. This study aimed to explore the functions and molecular mechanisms of plasmacytoma variant translocation I(PVT1) in ovarian cancer Methods: PVT1 and miR-214 were detected by qRT-PCR assays in ovarian cancer tissues and cells. The cell proliferation,migration, and invasion abilities were detected by cell functional experiments, respectively. Western blot assay was performed to detect epithelial-mesenchymal transition(EMT) markers. MiR-214 expression regulated by PVT1 was studied by RNA immunoprecipitation(RIP) and chromatin immunoprecipitation(Ch IP) assays.Results: The expression of PVT1 was up-regulated in ovarian cancer tissues and cell lines. Elevated PVT1 expression was associated with advanced stage and indicated poor prognosis for ovarian cancer patients. The knockdown of PVT1 impaired SKOV3 cell proliferation, migration, and invasion in vitro. The promotion of ovarian cancer progression by PVT1 involved in regulation of the epithelial-mesenchymal transition process and PVT1 interaction with EZH2 represses miR-214 expression in ovarian cancer cells.Conclusions: PVT1 plays an important role in ovarian cancer tumorigenesis, which might be as a novel diagnostic marker and therapeutic target for ovarian cancer.

Distributed Control of Multiple-Bus Microgrid With Paralleled Distributed Generators

A microgrid is hard to control due to its reduced inertia and increased uncertainties. To overcome the challenges of microgrid control, advanced controllers need to be developed.In this paper, a distributed, two-level, communication-economic control scheme is presented for multiple-bus microgrids with each bus having multiple distributed generators(DGs) connected in parallel. The control objective of the upper level is to calculate the voltage references for one-bus subsystems. The objectives of the lower control level are to make the subsystems' bus voltages track the voltage references and to enhance load current sharing accuracy among the local DGs. Firstly, a distributed consensusbased power sharing algorithm is introduced to determine the power generations of the subsystems. Secondly, a discrete-time droop equation is used to adjust subsystem frequencies for voltage reference calculations. Finally, a Lyapunov-based decentralized control algorithm is designed for bus voltage regulation and proportional load current sharing. Extensive simulation studies with microgrid models of different levels of detail are performed to demonstrate the merits of the proposed control scheme.

Distributed Periodic Event-Triggered Optimal Control of DC Microgrids Based on Virtual Incremental Cost

This article presents a distributed periodic eventtriggered(PET)optimal control scheme to achieve generation cost minimization and average bus voltage regulation in DC microgrids.In order to accommodate the generation constraints of the distributed generators(DGs),a virtual incremental cost is firstly designed,based on which an optimality condition is derived to facilitate the control design.To meet the discrete-time(DT)nature of modern control systems,the optimal controller is directly developed in the DT domain.Afterward,to reduce the communication requirement among the controllers,a distributed event-triggered mechanism is introduced for the DT optimal controller.The event-triggered condition is detected periodically and therefore naturally avoids the Zeno phenomenon.The closed-loop system stability is proved by the Lyapunov synthesis for switched systems.The generation cost minimization and average bus voltage regulation are obtained at the equilibrium point.Finally,switch-level microgrid simulations validate the performance of the proposed optimal controller.

Distributed Virtual Inertia Based Control of Multiple Photovoltaic Systems in Autonomous Microgrid

The large inertia of a traditional power system slows down system's frequency response but also allows decent time for controlling the system.Since an autonomous renewable microgrid usually has much smaller inertia,the control system must be very fast and accurate to fight against the small inertia and uncertainties.To reduce the demanding requirements on control,this paper proposes to increase the inertia of photovoltaic(PV) system through inertia emulation.The inertia emulation is realized by controlling the charging/discharging of the direct current(DC)-link capacitor over a certain range and adjusting the PV generation when it is feasible and/or necessary.By well designing the inertia,the DC-link capacitor parameters and the control range,the negative impact of inertia emulation on energy efficiency can be reduced.The proposed algorithm can be integrated with distributed generation setting algorithms to improve dynamic performance and lower implementation requirements.Simulation studies demonstrate the effectiveness of the proposed solution.

Genome-wide prediction in a hybrid maize population adapted to Northwest China

Genome-wide prediction is a promising approach to boost selection gain in hybrid breeding.Our main objective was to evaluate the potential and limits of genome-wide prediction to identify superior hybrid combinations adapted to Northwest China.A total of 490 hybrids derived from crosses among 119 inbred lines from the Shaan A and Shaan B heterotic pattern were used for genome-wide prediction of ten agronomic traits.We tested eight different statistical prediction models considering additive(A)effects and in addition evaluated the impact of dominance(D)and epistasis(E)on the prediction ability.Employing five-fold cross validation,we show that the average prediction ability ranged from 0.386 to 0.794 across traits and models.Six parametric methods,i.e.ridge regression,LASSO,Elastic Net,Bayes B,Bayes C and reproducing kernel Hilbert space(RKHS)approach,displayed a very similar prediction ability for each trait and two non-parametric methods(random forest and support vector machine)had a higher prediction performance for the trait rind penetrometer resistance of the third internode above ground(RPR_TIAG).The models of A+D RKHS and A+D+E RKHS were slightly better for predicting traits with a relatively high non-additive variance.Integrating trait-specific markers into the A+D RKHS model improved the prediction ability of grain yield by 3%,from 0.528 to 0.558.Of all 6328 potential hybrids,selection of the top 44 hybrids would lead to a 6%increase in grain yield compared with Zhengdan 958,a commercially successful hybrid variety.In conclusion,our results substantiate the value of genome-wide prediction for hybrid breeding and suggest dozens of promising single crosses for developing high-yielding hybrids for Northwest China.

Adaptive Decentralized Output-Constrained Control of Single-Bus DC Microgrids

A single-bus DC microgrid can represent a wide range of applications. Control objectives of such systems include high-performance bus voltage regulation and proper load sharing among multiple distributed generators(DGs) under various operating conditions. This paper presents a novel decentralized control algorithm that can guarantee both the transient voltage control performance and realize the predefined load sharing percentages. First, the output-constrained control problem is transformed into an equivalent unconstrained one. Second, a two-step backstepping control algorithm is designed based on the transformed model for bus-voltage regulation. Since the overall control effort can be split proportionally and calculated with locally-measurable signals, decentralized load sharing can be realized. The control design requires neither accurate parameters of the output filters nor load measurement. The stability of the transformed systems under the proposed control algorithm can indirectly guarantee the transient bus voltage performance of the original system. Additionally, the high-performance control design is robust, flexible, and reliable. Switch-level simulations under both normal and fault operating conditions demonstrate the effectiveness of the proposed algorithm.

Suitability Analysis of Scale Management in Northeast China Based on Efficiency Evaluation

Under the resource constraint of low per capita possession of cultivated land and the strategic requirements for ensuring national food security,the intensive and efficient use of cultivated land is an important topic for long-term research in China's academic circles. It is an important prerequisite for exploring the moderate scale management of agricultural land. The calculation results of 147 county-level units in Northeast China by DEA method show that in the use efficiency evaluation results of cultivated land of county-level units,the mean values of comprehensive efficiency,pure technical efficiency and scale efficiency were 0. 674,0. 705 and 0. 96,respectively,and the DEA effective units account for about 11%. The effective areas of pure technical efficiency and scale efficiency do not have a high level of superposition. To a certain extent,this also limits the improvement of overall efficiency. In view of the scale of family farmland management,counties and cities with an average per household possession of cultivated land of 1. 71-2. 13 ha can achieve both scale and efficiency through efficiency improvement.

An Analysis of Development Trend of Food Industry in Three Northeastern Provinces of China

The food industry has developed into a leading industry in Northeast China.However,various economic indicators have shown a significant downward trend in recent years.Through the systematic analysis of the development trend of food industry in Northeast China in the past ten years,especially in 2014,it is found that in the context of stable and smooth operation of the food industry in China,the efficiency of the main processing industries declines in the three northeastern provinces of China,there is a simultaneous decline in the share of output value of the leading industries in the output value of manufacturing sector in three provinces,the collective and individual capital withdrawal is obvious in the paid-up capital,and there is a simultaneous decline in the industrial production and sales rate and the export delivery value.The food industry in Northeast China has plunged into the dilemma of development.Finally,this article puts forward some targeted recommendations from aspects of policy making,industrial agglomeration and enterprise cultivation.

Spatial heterogeneity and compositional profiles of dissolved organic matter in farmland soils across China' Mainland

Dissolved organic matter(DOM) plays an essential role in many geochemical processes,however its complexity, chemical diversity, and molecular composition are poorly understood. Soil samples were collected from 500 vegetable fields in administrative regions of China' Mainland, of which 122 were selected for further investigation. DOM properties were characterized by three-dimensional excitation-emission matrix(3D-EEM) fuorescence spectroscopy and Fourier transform ion cyclotron resonance mass spectrometry(FTICRMS)(field intensity is 15 Tesla). Our results indicated that the main constituents were UVA humic-like substances, humic-like substances, fulvic acid-like substances, and tyrosine-like substances. A total of 10,989 molecular formulae with a mass range of 100.04 to 799.59 Da were detected, covering the mass spectrometric information of the soil samples from 27 different regions. CHO and CHON molecules were dominant in DOM, whereas lignin, tannins,and aromatic substances served as the main components. The results of cluster analysis revealed that the soil properties in Jiangxi Province were considerably different from those in other regions. The key backgrounds of the DOM molecular characteristics in the vegetablefield soil samples across China' Mainland were provided at the molecular level, with large abundance and great variability.

Market Rule or Equal Opportunity Rule:An Empirical Analysis Based on Acquisitions of Chinese Listed Companies

This paper examines the data of A-share listed companies in China from 2002 to 2017,drawing on the theory of equal opportunity and market rules in M&A transactions.This paper investigates the correlation between changes in tender offer policy and M&A tendencies and performance.The findings suggest that following the policy shift and the adoption of market rules,companies that secure an exemption from the mandatory tender offer obligation not only exhibit stronger M&A tendencies but also improved long-term M&A performance.This indicates that market rules are more suitable for China and contribute to enhancing the efficiency of the M&A market.The paper also presents evidence of a moderating effect,demonstrating that exemptions from the mandatory tender offer obligation positively influence the relationship between policy change and M&A performance.Lastly,this paper finds that state-owned and large-scale firms tend to exhibit a higher degree of M&A tendencies.

Type-B response regulator OsRR22 forms a transcriptional activation complex with OsSLR1 to modulate OsHKT2;1 expression in rice

Soil salinity severely limits crop yields and quality.Plants have evolved several strategies to mitigate the adverse effects of salinity,including redistribution and compartmentalization of toxic ions using ion-specific transporters.However,the mechanisms underlying the regulation of these ion transporters have not been fully elucidated.Loss-of-function mutants of OsHKT2;1,which is involved in sodium uptake,exhibit strong salt stress-resistant phenotypes.In this study,OsHKT2;1 was identified as a transcriptional target of the type-B response regulator OsRR22.Loss-of-function osrr22 mutants showed resilience to salt stress,and OsRR22-overexpression plants were sensitive to salt stress.OsRR22 was found to activate the expression of OsHKT2;1 by directly binding to the promoter region of OsHKT2;1 via a consensus cis-element of type-B response regulators.Moreover,rice DELLA protein OsSLR1 directly interacted with OsRR22 and functioned as a transcriptional co-activator.This study has uncovered a novel transcriptional regulatory mechanism by which a type-B response regulator controls sodium transport under salinity stress.

Real-time programmable metasurface for terahertz multifunctional wave front engineering

Terahertz(THz)technologies have become a focus of research in recent years due to their prominent role in envisioned future communication and sensing systems.One of the key challenges facing the field is the need for tools to enable agile engineering of THz wave fronts.Here,we describe a reconfigurable metasurface based on GaN technology with an array-of-subarrays architecture.This subwavelength-spaced array,under the control of a 1-bit digital coding sequence,can switch between an enormous range of possible configurations,providing facile access to nearly arbitrary wave front control for signals near 0.34 THz.We demonstrate wide-angle beam scanning with 1°of angular precision over 70 GHz of bandwidth,as well as the generation of multi-beam and diffuse wave fronts,with a switching speed up to 100 MHz.This device,offering the ability to rapidly reconfigure a propagating wave front for beam-forming or diffusively scattered wide-angle coverage of a scene,will open new realms of possibilities in sensing,imaging,and networking.

Regional characterization of vs30 with hybrid geotechnical and geological data

Regional characterization of soil properties requires not only geostatistical models considering the spatial variability of soil properties but also methods that account for various sources of heterogeneous information.This paper presents a multi-conditional random field approach to characterize the regional characteristics of the average shear-wave velocity in the top 30 meters of subsoil(vs30)based on hybrid geotechnical and geological data.The workflow for integrating multiple sources of soil properties information in a random field model for regional vs30 mapping is developed.A detailed two-dimensional(2D)synthetic digital soil field is generated to assess and verify this workflow.With the generated synthetic field,parametric studies on the investigation plans,the value of Markov Bayes coefficient B,element size,and a predefined grid of secondary data are performed.Practice on whether to incorporate secondary data for vs30 mapping and the determination of coefficient B are provided.

Enhancing phosphorus uptake efficiency through QTL-based selection for root system architecture in maize

Root system architecture （RSA） plays an important role in phosphorus （P） acquisition, but enhancing P use efficiency （PUE） in maize via genetic manipulation of RSA has not yet been reported. Here, using a maize recombinant inbred line （RIL） population, we investigated the genetic relationships between PUE and RSA, and developed P-efficient lines by selection of quantitative trait loci （QTLs） that coincide for both traits. In low-P （LP） fields, P uptake efficiency （PupE） was more closely correlated with PUE （r = 0.48 -0.54）, and RSA in hydroponics was significantly related to PupE （r=0.25-0.30） but not to P utilization efficiency （PutE）. QTL analysis detected a chromosome region where two QTLs for PUE, three for PupE and three for RSA were assigned into two QTL clusters, Cl-bin3.04a and Cl-bin3.04b. These QTLs had favorable effects from alleles derived from the large-rooted and high-PupE parent. Marker-assisted selection （MAS） identified nine advanced backcross-derived lines carrying Cl-bin3.04a or Cl-bin3.04b that displayed mean increases of 22%-26% in PUE in LP fields. Furthermore, a line L224 pyramiding Cl- binB.04a and Cl-bin3.04b showed enhanced PupE, relying mainly on changes in root morphology, rather than root physiology, under both hydroponic and field conditions. These results highlight the physiological and genetic contributions of RSA to maize PupE, and provide a successful study case of developing P-efficient crops through QTL-based selection.

Emission factors of particulate matter, CO and CO_2 in the pyrolytic processing of typical electronic wastes

A self-designed experimental device was employed to simulate the pyrolytic dismantling process of selected electronic wastes(E-wastes), including printed wiring boards(PWBs)and plastic casings. The generated particulate matter(PM) of different particle sizes, carbon monoxide(CO) and carbon dioxide(CO_2) were determined, and the corresponding emission factors(EFs) were estimated. Finer particles with particle sizes of 0.4–2.1 μm accounted for78.9% and 89.3% of PM emitted by the pyrolytic processing of PWBs and plastic casings,respectively, and the corresponding EFs were 9.68 ± 4.81 and 18.49 ± 7.2 g/kg, respectively.The EFs of CO and CO_2 from PWBs and plastic casings were 55.9 ± 26.9 and 1182 ± 439 g/kg,and 133.6 ± 34.6 and 2827 ± 276 g/kg, respectively. Compared with other emission sources,such as coal, biomass, and traffic exhaust, the EFs of E-wastes were relatively higher,especially for PM. There were significant positive correlations(p < 0.05) of the initial contents of carbon and nitrogen in PWBs with the related EFs of PM, CO, and CO_2, while the correlations for plastic casings were insignificant. The EFs of CO of PWBs were significantly positively correlated with the corresponding EFs of PM and the parent polycyclic aromatic hydrocarbons(PAHs); however, the same result was not observed for plastic casings.

Highly efficient dual-wavelength acousto-optically Q-switched Tm,La:CaF_(2)laser

A highly efficient milli-joule-level Q-switched Tm,La:CaF_(2)laser is experimentally demonstrated.By employing an acousto-optic modulator,the diode-pumped pulsed lasers are stably operated at repetition rates ranging from 500 Hz to 10 kHz.Dual-wavelength operation of 1881.7 nm and 1888.5 nm is achieved with slope efficiency of 64.7%.Up to 1.89 mJ of pulse energy is obtained at a pulse width of 100 ns,corresponding to a peak power of 18.88 kW.These results verified that the Tm,La:CaF_(2)crystal could be a promising candidate for achieving highly efficient and high-energy pulsed lasers.

HEXOKINASE1 forms a nuclear complex with the PRC2 subunits CURLY LEAF and SWINGER to regulate glucose signaling

The glucose sensor HEXOKINASE1(HXK1)integrates myriad external and internal signals to regulate gene expression and development in Arabidopsis thaliana.However,how HXK1 mediates glucose signaling in the nucleus remains unclear.Here,using immunoprecipitationcoupled mass spectrometry,we show that two catalytic subunits of Polycomb Repressive Complex 2,SWINGER(SWN)and CURLY LEAF(CLF),directly interact with catalytically active HXK1 and its inactive forms(HXK1^(G104D) and HXK1^(S177A))via their evolutionarily conserved SANT domains.HXK1,CLF,and SWN target common glucose-responsive genes to regulate glucose signaling,as revealed by RNA sequencing.The glucose-insensitive phenotypes of the Arabidopsis swn-1 and clf-50 mutants were similar to that of hxk1,and genetic analysis revealed that CLF,SWN,and HXK1 function in the same genetic pathway.Intriguingly,HXK1 is required for CLF-and SWN-mediated histone H3 lysine 27(H3K27me3)deposition and glucose-mediated gene repression.Moreover,CLF and SWN affect the recruitment of HXK1 to its target chromatin.These findings support a model in which HXK1 and epigenetic modifiers form a nuclear complex to cooperatively mediate glucose signaling,thereby affecting the histone modification and expression of glucoseregulated genes in plants.