Terrain is an important environment factor that plays a vital role in human development by influencing the spatial layout of land use patterns. The terrain niche index, combined with slope and elevation, can comprehen...Terrain is an important environment factor that plays a vital role in human development by influencing the spatial layout of land use patterns. The terrain niche index, combined with slope and elevation, can comprehensively present detailed information about spatial differences in terrain and is superior to single terrain factors. We applied remote sensing and geographical information system to terrain gradient, used the non-dimensional distribution index to examine spatial distribution characteristics of various landscape types, and analyzed the ecological effects of landscape were quantitatively on terrain gradients. Eco-environment quality (EEQ) was evaluated using the forestry operation area as the evaluation unit. The spatial distributions in various landscapes were significantly influenced by terrain factors, especially by bodies of water, cropland and residential land. The spatial distribution varied greatly in different terrain gradients for similar landscape types. The areas associated with good, intermediate and poor EEQ were occupied primarily by natural landscape, semi-natural and largely artificial landscapes, respectively.展开更多
This study investigates aberrant DNA methylations as potential diagnosis and prognosis markers for esophageal squamous-cell carcinoma(ESCC),which if diagnosed at advanced stages has<30%five-year survival rate.Compa...This study investigates aberrant DNA methylations as potential diagnosis and prognosis markers for esophageal squamous-cell carcinoma(ESCC),which if diagnosed at advanced stages has<30%five-year survival rate.Comparing genome-wide methylation sites of 91 ESCC and matched adjacent normal tissues,we identified 35,577 differentially methylated CpG sites(DMCs)and characterized their distribution patterns.展开更多
Esophageal squamous-cell carcinoma （ESCC） is one of the most lethal malignancies in the world and occurs at particularly higher frequency in China. While several genome-wide association studies （GWAS） of germline ...Esophageal squamous-cell carcinoma （ESCC） is one of the most lethal malignancies in the world and occurs at particularly higher frequency in China. While several genome-wide association studies （GWAS） of germline variants and whole-genome or whole-exome sequencing studies of somatic mutations in ESCC have been published, there is no comprehensive database publically available for this cancer. Here, we developed the Chinese Cancer Genomic Database-Esophageal Squamous Cell Carcinoma （CCGD-ESCC） database, which contains the associations of 69,593 single nucleotide polymorphisms （SNPs） with ESCC risk in 2022 cases and 2039 controls, survival time of 1006 ESCC patients （survival GWAS） and gene expression （expression quantitative trait loci,eQTL） in 94 ESCC patients. Moreover, this database also provides the associations between8833 somatic mutations and survival time in 675 ESCC patients. Our user-friendly database is a resource useful for biologists and oncologists not only in identifying the associations of genetic variants or somatic mutations with the development and progression of ESCC but also in studying the underlying mechanisms for tumorigenesis of the cancer. CCGD-ESCC is freely accessible at http：//db.cbi.pku.edu.cn/ccgd/ESCCdb.展开更多
基金supported by National High Technology Research and Development Program 863(Grant No.2012AA102001)Natural Scientific Foundation of Heilongjiang Province(Grant No.D201410)Natural Science Foundation of Heilongjiang Province Department Education Commission(Grant No.12531513)
文摘Terrain is an important environment factor that plays a vital role in human development by influencing the spatial layout of land use patterns. The terrain niche index, combined with slope and elevation, can comprehensively present detailed information about spatial differences in terrain and is superior to single terrain factors. We applied remote sensing and geographical information system to terrain gradient, used the non-dimensional distribution index to examine spatial distribution characteristics of various landscape types, and analyzed the ecological effects of landscape were quantitatively on terrain gradients. Eco-environment quality (EEQ) was evaluated using the forestry operation area as the evaluation unit. The spatial distributions in various landscapes were significantly influenced by terrain factors, especially by bodies of water, cropland and residential land. The spatial distribution varied greatly in different terrain gradients for similar landscape types. The areas associated with good, intermediate and poor EEQ were occupied primarily by natural landscape, semi-natural and largely artificial landscapes, respectively.
基金Supported by National Natural Science Foundation of China(81988101 to D.L.and C.W.)National Science Fund for Distinguished Young Scholars(81725015 to C.W.)+2 种基金Chinese Academy Medical Sciences Innovation Fund for Medical Sciences(2021-I2M-1-013 to D.L.,C.W.and W.T.,2019-I2M-2-001 to D.L and C.W.)Beijing Outstanding Young Scientist Program(BJJWZYJH01201910023027 to C.W.)the National Key R&D Program of China(2021YFC2502000 to Y.L.).
文摘This study investigates aberrant DNA methylations as potential diagnosis and prognosis markers for esophageal squamous-cell carcinoma(ESCC),which if diagnosed at advanced stages has<30%five-year survival rate.Comparing genome-wide methylation sites of 91 ESCC and matched adjacent normal tissues,we identified 35,577 differentially methylated CpG sites(DMCs)and characterized their distribution patterns.
基金supported by CAMS Innovation Fund for Medical Sciences (Grant No. 2016-I2M-4-002 awarded to CW)the National Key R&D Program (Grant No. 2016YFC1302701 to CW and Grant No. 2016YFC0901603 to GG)
文摘Esophageal squamous-cell carcinoma （ESCC） is one of the most lethal malignancies in the world and occurs at particularly higher frequency in China. While several genome-wide association studies （GWAS） of germline variants and whole-genome or whole-exome sequencing studies of somatic mutations in ESCC have been published, there is no comprehensive database publically available for this cancer. Here, we developed the Chinese Cancer Genomic Database-Esophageal Squamous Cell Carcinoma （CCGD-ESCC） database, which contains the associations of 69,593 single nucleotide polymorphisms （SNPs） with ESCC risk in 2022 cases and 2039 controls, survival time of 1006 ESCC patients （survival GWAS） and gene expression （expression quantitative trait loci,eQTL） in 94 ESCC patients. Moreover, this database also provides the associations between8833 somatic mutations and survival time in 675 ESCC patients. Our user-friendly database is a resource useful for biologists and oncologists not only in identifying the associations of genetic variants or somatic mutations with the development and progression of ESCC but also in studying the underlying mechanisms for tumorigenesis of the cancer. CCGD-ESCC is freely accessible at http：//db.cbi.pku.edu.cn/ccgd/ESCCdb.
