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体重指数与急性冠脉综合征患者院内不良心脑血管事件的相关性 被引量:1
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作者 周晴 朱丹 +8 位作者 王怡亭 董文阅 杨杰 温军 刘军 杨娜 赵冬 花欣炜 唐熠达 《中华心血管病杂志》 CAS CSCD 北大核心 2024年第1期42-48,共7页
目的了解体重指数(BMI)与急性冠脉综合征(ACS)患者院内主要不良心脑血管事件(MACCE)的相关性。方法该研究是一项多中心前瞻性队列研究。研究数据来源于中国心血管疾病医疗质量改善(CCC)项目。入选2014年11月1日至2019年12月31日CCC项目... 目的了解体重指数(BMI)与急性冠脉综合征(ACS)患者院内主要不良心脑血管事件(MACCE)的相关性。方法该研究是一项多中心前瞻性队列研究。研究数据来源于中国心血管疾病医疗质量改善(CCC)项目。入选2014年11月1日至2019年12月31日CCC项目中年龄介于18~80岁的ACS住院患者,按照入院第1次测得的BMI分为4组:低体重组(BMI<18.5 kg/m^(2))、正常体重组(BMI 18.5~24.9 kg/m^(2))、超重组(BMI 25.0~29.9 kg/m^(2))和肥胖组(BMI≥30.0 kg/m^(2))。主要结局为住院期间发生的MACCE,包括全因死亡、再次心肌梗死、心力衰竭、心原性休克、心脏骤停和卒中。采用多因素logistic回归模型分析BMI与院内MACCE发生风险的关系。结果研究共纳入71681例ACS住院患者,年龄(63.4±14.7)岁,女性占26.5%(18979/71681),低体重组、正常体重组、超重组和肥胖组分别有2154、41960、24140和3427例。低体重组、正常体重组、超重组和肥胖组的院内MACCE发生率分别为14.9%(322/2154)、9.5%(3997/41960)、7.9%(1908/24140)和7.0%(240/3427)(P<0.001)。多因素logistic回归分析结果显示,低体重组的MACCE发生风险高于正常体重组(OR=1.30,95%CI 1.13~1.49,P<0.001),超重组和肥胖组MACCE发生风险与正常体重组差异均无统计学意义(P均>0.05)。结论BMI低于正常的ACS患者院内MACCE发生风险高,BMI有可能成为评价ACS患者短期预后的一项指标。 展开更多
关键词 急性冠状动脉综合征 体重指数 预后
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Formate as a supplementary substrate facilitates sugar metabolism and solvent production by Clostridium beijerinckii NCIMB 8052
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作者 Ran Zhao wenyue dong +3 位作者 Chen Yang Weihong Jiang Jinzhong Tian Yang Gu 《Synthetic and Systems Biotechnology》 SCIE CSCD 2023年第2期196-205,共10页
Microbial utilization and conversion of organic one-carbon compounds,such as formate and methanol that can be easily produced from CO_(2),has emerged as an attractive approach for biorefinery.In this study,we discover... Microbial utilization and conversion of organic one-carbon compounds,such as formate and methanol that can be easily produced from CO_(2),has emerged as an attractive approach for biorefinery.In this study,we discovered Clostridium beijerinckii NCIMB 8052,a typical solventogenic Clostridium strain,to be a native formate-utilizing bacterium.^(13)C isotope analysis showed that formate could be metabolized via both assimilation and dissimi-lation pathways in C.beijerinckii NCIMB 8052.Notably,the use of formate as the supplementary substrate by this strain could significantly enhance its glucose consumption and ABE(acetone-butanol-ethanol)production,largely due to the up-regulation of genes responsible for glycolysis and glucose transport under formate stress.Based on these findings,we further improved formate tolerance of C.beijerinckii NCIMB 8052 by adaptive lab-oratory evolution,generating an evolved strain Cbei-FA01.The Cbei-FA01 strain could produce 23.0 g/L of ABE solvents using glucose and formate as dual substrates,~50%higher than that of the wild-type strain under the same condition.Moreover,such a promotion effect of formate on ABE production by Cbei-FA01 was also observed in fermenting a glucose-xylose mixture.This work reveals a previously unreported role of formate in biological ABE production,providing a new approach to utilize this one-carbon source. 展开更多
关键词 Formate utilization Clostridium beijerinckii Metabolic pathways Adaptive laboratory evolution ABE solvents
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Alkoxy encapsulation of carbazole-based thermally activated delayed fluorescent dendrimers for highly efficient solution-processed organic light-emitting diodes 被引量:1
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作者 Zhihua Ma Yuchun Wan +3 位作者 wenyue dong Zhenjun Si Qian Duan Shiyang Shao 《Chinese Chemical Letters》 SCIE CAS CSCD 2021年第2期703-707,共5页
Two n-butoxy-encapsulated dendritic thermally activated delayed fluorescent(TADF) emitters(namely O-D1 and O-D2) with the first-/second-generation carbazoledendrons are designed and synthesized via C—N coupling betwe... Two n-butoxy-encapsulated dendritic thermally activated delayed fluorescent(TADF) emitters(namely O-D1 and O-D2) with the first-/second-generation carbazoledendrons are designed and synthesized via C—N coupling between carbazoledendrons and 2,4,6-tris(4-bromophenyl)-1,3,5-triazine core.It is found that,compa red with the commo nly-used tert-butyl groups,the use of n-butoxy encapsulation groups can lead to smallersinglet-triplet energy gap for the dendrimers,producing stronger TADF effect together with faster reverse intersystem crossing process.Solution-processed TADF organic light-emitting diodes(OLEDs) utilizingalkoxy-encapsulated dendrimers O-D1 and O-D2 as emitters exhibitstate-of-the-art device efficiency withthe maximum external quantum efficiency up to 16.8% and 20.6%,respectively,which are ~1.6 and~2.0 times that of the tert-butyl-encapsulated counterparts.These results suggest that alkoxy encapsulation of the carbazole-based TADF dendrimers can be a promising approach for developing highly efficient emitters for solution-processed OLEDs. 展开更多
关键词 Alkoxy encapsulation Thermally activated delayed fluorescence Dendrimer Organic light-emitting diodes
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