Obese individuals have slowed conduction in the median nerve across the wrist, but the mechanism for this is not established. This case control study of 27 o bese subjects and 16 thin subjects was designed to test the...Obese individuals have slowed conduction in the median nerve across the wrist, but the mechanism for this is not established. This case control study of 27 o bese subjects and 16 thin subjects was designed to test the hypothesis that obes e individuals have higher carpal canal pressures and more median nerve swelling than thin individuals. Allsubjects were asymptomatic for hand symptoms, and had measurements of median and ulnar sensory nerve conduction in the nondominant han d, ultrasound measurement of the median nerve cross sectional area proximal to the carpalcanal, and carpal canal pressure measurement. There was no difference in age or gender ratio between the obese and thin groups. The median nerve cross sectional area was equal in the obese and thin groups (9.3 mm2 vs. 9.4 mm2), a s was the carpal canal pressure (16.2 mmHg vs. 15.5 mmHg, respectively). There w as a strong correlation between median nerve conduction slowing across the wrist and median nerve cross sectional area at the wrist (r = 0.55, P = 0.002). Obes ity does not influence carpal canal pressure or the size of the median nerve at the wrist. However, t here is a strong association between slowed median nerve conduction and increase d nerve size which suggests endoneurial edema as a metabolic mechanism; the cond uction slowing does not appear to be related to mechanical stress.展开更多
文摘Obese individuals have slowed conduction in the median nerve across the wrist, but the mechanism for this is not established. This case control study of 27 o bese subjects and 16 thin subjects was designed to test the hypothesis that obes e individuals have higher carpal canal pressures and more median nerve swelling than thin individuals. Allsubjects were asymptomatic for hand symptoms, and had measurements of median and ulnar sensory nerve conduction in the nondominant han d, ultrasound measurement of the median nerve cross sectional area proximal to the carpalcanal, and carpal canal pressure measurement. There was no difference in age or gender ratio between the obese and thin groups. The median nerve cross sectional area was equal in the obese and thin groups (9.3 mm2 vs. 9.4 mm2), a s was the carpal canal pressure (16.2 mmHg vs. 15.5 mmHg, respectively). There w as a strong correlation between median nerve conduction slowing across the wrist and median nerve cross sectional area at the wrist (r = 0.55, P = 0.002). Obes ity does not influence carpal canal pressure or the size of the median nerve at the wrist. However, t here is a strong association between slowed median nerve conduction and increase d nerve size which suggests endoneurial edema as a metabolic mechanism; the cond uction slowing does not appear to be related to mechanical stress.
