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Role of Positive Selection Pressure on the Evolution of H5N1 Hemagglutinin 被引量:6
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作者 Venkata r.S.K. Duvvuri Bhargavi Duvvuri +2 位作者 wilfred r. cuff Gillian E. Wu Jianhong Wu 《Genomics, Proteomics & Bioinformatics》 SCIE CAS CSCD 2009年第1期47-56,共10页
The surface glycoprotein hemagglutinin (HA) helps the influenza A virus to evade the host immune system by antigenic variation and is a major driving force for viral evolution. In this study, the selection pressure ... The surface glycoprotein hemagglutinin (HA) helps the influenza A virus to evade the host immune system by antigenic variation and is a major driving force for viral evolution. In this study, the selection pressure on HA of H5N1 influenza A virus was analyzed using bioinformatics algorithms. Most of the identified positive selection (PS) sites were found to be within or adjacent to epitope sites. Some of the identified PS sites are consistent with previous experimental studies, providing further support to the biological significance of our findings. The highest frequency of PS sites was observed in recent strains isolated during 2005-2007. Phylogenetic analysis was also conducted on HA sequences from various hosts. Viral drift is almost similar in both avian and human species with a progressive trend over the years. Our study reports new mutations in functional regions of HA that might provide markers for vaccine design or can be used to predict isolates of pandemic potential. 展开更多
关键词 positive selection H5N1 HEMAGGLUTININ EPITOPE BIOINFORMATICS
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A Novel Interpretation of Structural Dot Plots of Genomes Derived from the Analysis of Two Strains of Neisseria meningitidis
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作者 wilfred r. cuff Venkata r.S.K. Duvvuri +4 位作者 Binhua Liang Bhargavi Duvvuri Gillian E. Wu Jianhong Wu raymond S.W. Tsang 《Genomics, Proteomics & Bioinformatics》 SCIE CAS CSCD 2010年第3期159-169,共11页
Neisseria meningitidis is the agent of invasive meningococcal disease, including cerebral meningitis and septicemia. Because the diseases caused by different clonal groups (sequence types) have their own epidemiolog... Neisseria meningitidis is the agent of invasive meningococcal disease, including cerebral meningitis and septicemia. Because the diseases caused by different clonal groups (sequence types) have their own epidemiological characteristics, it is important to understand the differences among the genomes of the N. meningitidis clonal groups. To this end, a novel interpretation of a structural dot plot of genomes was devised and applied; exact nu- cleotide matches between the genomes ofN. meningitidis serogroup A strain Z2491 and serogroup B strain MC58 were identified, leading to the specification of various structural regions. Known and putative virulence genes for each N. meningitidis strain were then classified into these regions. We found that virulence genes of MC58 tend more to the translocated regions (chromosomal segments in new sequence contexts) than do those of Z2491, notably tending towards the interface between one of the translocated regions and the collinear region. Within the col- linear region, virulence genes tend to occur within 16 kb of gaps in the exact matches. Verification of these tendencies using genes clustered in the cps locus was sufficiently supportive to suggest that these tendencies can be used to focus the search for and understanding of virulence genes and mechanisms of pathogenicity in these two organisms. 展开更多
关键词 structural dot plots virulence genes TRANSLOCATION match regions MUMmer Neisseria meningitidis
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