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0.2%酒石酸溴莫尼定治疗急性非动脉炎性前部缺血性视神经病变(NAION)的功效及耐受性研究:1项历时3月、安慰剂对照、随机双盲试验
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作者 wilhelm B. Lüdtke h. +1 位作者 wilhelm h. 刘瑛 《世界核心医学期刊文摘(眼科学分册)》 2006年第10期36-37,共2页
Introduction:Neuroprotection may be an option in ischemic optic nerve disease.There have been promising reports about the neuroprotective ability of topical brimonidine in animal studies.Therefore,we tested whether 0.... Introduction:Neuroprotection may be an option in ischemic optic nerve disease.There have been promising reports about the neuroprotective ability of topical brimonidine in animal studies.Therefore,we tested whether 0.2% brimonidine tartrate could improve the outcome of patients with non-arteritic anterior ischemic optic neuropathy(NAION).The study was stopped after an interim analysis,having not proven its feasibility within practicable time frame.Methods:A 3-month,double-masked,placebo-controlled,randomised European multicenter trial conducted according to good clinical practice rules.Thirty-six patients(22 m,14 f),older than 40 years with first eye involvement and typical signs of NAION were included in the study within the 1st week after visual loss(VA 0.05-1.0)and were randomized to treatment with either brimonidine 0.2%(Alphagan)or placebo.Visual acuity(VA,primary endpoint),visual field(VF,Humphrey 30-2 and Goldmann,quantified by a modified Esterman grid)and automated swinging flashlight test(SWIFT)were performed at baseline,2 weeks,4 weeks and 12 weeks after first visit.Primary analysis aimed at intention-to-treat group(ITT,n=29),secondary analysis to the per protocol population(PP,n=25).Tolerability and safety were tested in the safety group(n=36).A two-sample two-sided t-test was used for statistical analysis(alpha level at 0.05).Results:VA did not show statistically significant difference by treatment.There were non-significant trends for better visual field results in the brimonidine group.Adverse events consisting of local irritation were observed six times in the verum and three times in the placebo group.No serious adverse events occurred.Conclusion:In contradiction to an open-labeled,retrospective study published by Fazzone et al.,the results of this trial did not indicate any harmful effect of brimonidine in patients suffering from NAION.However,a statistically significant advantage for the patients receiving brimonidine tartrate could not be shown. 展开更多
关键词 NAION 酒石酸溴莫尼定 随机双盲 动脉炎 安慰剂对照 视神经疾病 视野检查 阿法根 药物不良事件
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致命性眶部病变
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作者 Von Eicken J. Preyer S. +1 位作者 wilhelm h. 秦雪娇 《世界核心医学期刊文摘(眼科学分册)》 2005年第5期42-42,共1页
Fulminant processes of the orbit can cause considerable diagnostic difficultie s with regards to the clinical, radiological and microbiological appearance. Rhi noorbitocerebral mucormycosis is a rare but, when untreat... Fulminant processes of the orbit can cause considerable diagnostic difficultie s with regards to the clinical, radiological and microbiological appearance. Rhi noorbitocerebral mucormycosis is a rare but, when untreated, fatal orbital disea se capable of destructive infiltration of soft tissue and bone. It occurs prefer ably in the ill adjusted diabetic or in the course of an immunodeficiency. The f ollowing case report describes a leukaemia patient developing a severe rhinoorbi tocerebral mucormycosis which was initially not recognised. Since untreated muco rmycosis is fatal, an aggressive surgical approach with excision of the wholenec rotic area is necessary even if the diagnosis cannot be confirmed with certainty . 展开更多
关键词 眶部 真菌病 免疫缺陷患者 暴发性
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