PURPOSE: To characterize the clinical features and therapeutic outcome of stromal keratitis associated with syphilis in adults. DESIGN: Observational case series. METHODS: We examined the clinical and laboratory recor...PURPOSE: To characterize the clinical features and therapeutic outcome of stromal keratitis associated with syphilis in adults. DESIGN: Observational case series. METHODS: We examined the clinical and laboratory records at a single center of individuals with active stromal keratitis who had serological evidence of syphilis by a treponemal specific test. RESULTS: Five patients, 36 to 81 years of age, developed stromal keratitis during late syphilis. One patient with developmental signs of congenital syphilis had bilateral stromal keratitis. The others were otherwise healthy when they presented with unilateral, nonulcerative, infiltrative keratitis with stromal edema of the peripheral or paracentral cornea and mild to moderate corneal vascularization. All had an appropriate response to topical corticosteroid therapy, and two recovered good vision. Stromal keratitis recurred in two patients months to years later. CONCLUSIONS: Nonulcerative stromal keratitis presents in adults with syphilis as marginal, central, or multifocal stromal inflammation with neovascularization that responds to corticosteroid therapy but occasionally recurs.展开更多
Aims: To estimate the propensity of keratomycosis for parallel or secondary bacterial infection and to explore affinities among fungal and bacterial co-isolates. Methods: A retrospective review of laboratory records o...Aims: To estimate the propensity of keratomycosis for parallel or secondary bacterial infection and to explore affinities among fungal and bacterial co-isolates. Methods: A retrospective review of laboratory records over 24 years yielded 152 episodes of culture positive fungal keratitis. After collating 65 corneal specimens having bacterial co-isolates, polymicrobial co-infection was defined as detection of concordant bacteria on smear and culture or on two or more different media. Results: 30 (20% ) keratomycoses met laboratory criteria for polymicrobial infection. The risk of bacterial co-infection was 3.2 (95% confi-dence interval, 1.7 to 5.8) times greater with yeast keratitis than with filamentous fungal keratitis. Conclusions: Bacterial coinfection occasionally complicates fungal keratitis, particularly candidiasis.展开更多
文摘PURPOSE: To characterize the clinical features and therapeutic outcome of stromal keratitis associated with syphilis in adults. DESIGN: Observational case series. METHODS: We examined the clinical and laboratory records at a single center of individuals with active stromal keratitis who had serological evidence of syphilis by a treponemal specific test. RESULTS: Five patients, 36 to 81 years of age, developed stromal keratitis during late syphilis. One patient with developmental signs of congenital syphilis had bilateral stromal keratitis. The others were otherwise healthy when they presented with unilateral, nonulcerative, infiltrative keratitis with stromal edema of the peripheral or paracentral cornea and mild to moderate corneal vascularization. All had an appropriate response to topical corticosteroid therapy, and two recovered good vision. Stromal keratitis recurred in two patients months to years later. CONCLUSIONS: Nonulcerative stromal keratitis presents in adults with syphilis as marginal, central, or multifocal stromal inflammation with neovascularization that responds to corticosteroid therapy but occasionally recurs.
文摘Aims: To estimate the propensity of keratomycosis for parallel or secondary bacterial infection and to explore affinities among fungal and bacterial co-isolates. Methods: A retrospective review of laboratory records over 24 years yielded 152 episodes of culture positive fungal keratitis. After collating 65 corneal specimens having bacterial co-isolates, polymicrobial co-infection was defined as detection of concordant bacteria on smear and culture or on two or more different media. Results: 30 (20% ) keratomycoses met laboratory criteria for polymicrobial infection. The risk of bacterial co-infection was 3.2 (95% confi-dence interval, 1.7 to 5.8) times greater with yeast keratitis than with filamentous fungal keratitis. Conclusions: Bacterial coinfection occasionally complicates fungal keratitis, particularly candidiasis.
