A successful tissue regeneration is a very complex process that requires a precise coordination of many molecular,cellular and physiological events.One of the critical steps is to convert the injury signals into regen...A successful tissue regeneration is a very complex process that requires a precise coordination of many molecular,cellular and physiological events.One of the critical steps is to convert the injury signals into regeneration signals to initiate tissue regeneration.Although many efforts have been made to investigate the mechanisms triggering tissue regeneration,the fundamental questions remain unresolved.One of the major obstacles is that the injury and the initiation of regeneration are two highly coupled processes and hard to separate from one another.In this article,we review the major events occurring at the early injury/regeneration stage in a range of species,and discuss the possible common mechanisms during initiation of tissue regeneration.展开更多
基金Ji-Feng Fei was supported by the National Key R&D Program of China 2019YFE0106700the Natural Science Foundation of China 31970782,Project of Department of Education of Guangdong Province 2018KZDXM027+1 种基金Key-Area Research and Development Program of Guangdong Province 2018B030332001,2019B030335001Yanmei Liu was supported by the Natural Science Foundation of China 32070819,91854112,91750203.
文摘A successful tissue regeneration is a very complex process that requires a precise coordination of many molecular,cellular and physiological events.One of the critical steps is to convert the injury signals into regeneration signals to initiate tissue regeneration.Although many efforts have been made to investigate the mechanisms triggering tissue regeneration,the fundamental questions remain unresolved.One of the major obstacles is that the injury and the initiation of regeneration are two highly coupled processes and hard to separate from one another.In this article,we review the major events occurring at the early injury/regeneration stage in a range of species,and discuss the possible common mechanisms during initiation of tissue regeneration.
