Although often used as a reference standard in the breath hydrogen test(BHT), lactulose fermentation produces more hydrogen, compared to starch, and may there fore not be ideal. This study compares inulin with lactulo...Although often used as a reference standard in the breath hydrogen test(BHT), lactulose fermentation produces more hydrogen, compared to starch, and may there fore not be ideal. This study compares inulin with lactulose as reference standa rd in the study of carbohydrate malabsorption. Seventeen patients with malabsorp tion due to chronic pancreatitis and 15 normal controls were studied. Following overnight fasts, BHTs were performed after ingesting 10 g lactulose, 10 g inulin , and 200 g(16 g highly resistant starch) maize meal. Lactulose fermentation pro duced significantly more hydrogen than inulin in patients with malabsorption (97 ±20 vs 45±22 ppm·hr; P < 0.05) and controls (43 ±18 vs 21 ±10 ppm·hr; P < 0.05). Patients produced more hydrogen than controls with both standards (lactul ose, 97 ±20 vs 43 ±18 ppm·hr, P < 0.05; inulin 45 ±22 vs 21 ±10 ppm·hrs; P < 0.05), suggesting adaptation of the colonic flora. Calculated CHO malabsorpti on was 2.5 ±0.8 vs 5.2 ±3.8 g with lactulose and 5.2 ±3.1 vs 11.2 ±9.6 g wit h inulin as standards in controls and patients, respectively (P < 0.05). Lactulo se produces more breath hydrogen than inulin. Calculation of CHO malabsorption u sing these standards is therefore not comparable.展开更多
Our purpose was to study the effect of Helicobacter pylori (HP)on mucosal protein fractional synthesis (MPFS) and growth factor expression. 14C-leucine incorporation, and TGF-α , β-FGF, and EGF-receptor levels were ...Our purpose was to study the effect of Helicobacter pylori (HP)on mucosal protein fractional synthesis (MPFS) and growth factor expression. 14C-leucine incorporation, and TGF-α , β-FGF, and EGF-receptor levels were assessed in gastric and duodenal mucosa in 20 patients with HP-associated gastritis and repeated after treatment of the gastritis, with or without eradication of the organism. At entry, MPFS in the fundus,antrum, and duodenum was 43.1, 38.2, and 28.3%/day, respectively.Following HP eradication, fundal and antral rates fell to 28.1 and 21.4%/day (P<0.05), whereas the duodenum was unchanged. MPFS in the patient subset not eradicated remained similar to entry values (35.9, 31.6, and 25.4%/day). Expression of TGF-α , β-FGF, and EGF receptors was unchanged. Eradication of HP results in reduction of gastric, but not duodenal,MPFS and has no effect on the growth factors measured. Increased MPFS associated with HP gastritis may relate to the potential for neoplastic transformation.展开更多
文摘Although often used as a reference standard in the breath hydrogen test(BHT), lactulose fermentation produces more hydrogen, compared to starch, and may there fore not be ideal. This study compares inulin with lactulose as reference standa rd in the study of carbohydrate malabsorption. Seventeen patients with malabsorp tion due to chronic pancreatitis and 15 normal controls were studied. Following overnight fasts, BHTs were performed after ingesting 10 g lactulose, 10 g inulin , and 200 g(16 g highly resistant starch) maize meal. Lactulose fermentation pro duced significantly more hydrogen than inulin in patients with malabsorption (97 ±20 vs 45±22 ppm·hr; P < 0.05) and controls (43 ±18 vs 21 ±10 ppm·hr; P < 0.05). Patients produced more hydrogen than controls with both standards (lactul ose, 97 ±20 vs 43 ±18 ppm·hr, P < 0.05; inulin 45 ±22 vs 21 ±10 ppm·hrs; P < 0.05), suggesting adaptation of the colonic flora. Calculated CHO malabsorpti on was 2.5 ±0.8 vs 5.2 ±3.8 g with lactulose and 5.2 ±3.1 vs 11.2 ±9.6 g wit h inulin as standards in controls and patients, respectively (P < 0.05). Lactulo se produces more breath hydrogen than inulin. Calculation of CHO malabsorption u sing these standards is therefore not comparable.
文摘Our purpose was to study the effect of Helicobacter pylori (HP)on mucosal protein fractional synthesis (MPFS) and growth factor expression. 14C-leucine incorporation, and TGF-α , β-FGF, and EGF-receptor levels were assessed in gastric and duodenal mucosa in 20 patients with HP-associated gastritis and repeated after treatment of the gastritis, with or without eradication of the organism. At entry, MPFS in the fundus,antrum, and duodenum was 43.1, 38.2, and 28.3%/day, respectively.Following HP eradication, fundal and antral rates fell to 28.1 and 21.4%/day (P<0.05), whereas the duodenum was unchanged. MPFS in the patient subset not eradicated remained similar to entry values (35.9, 31.6, and 25.4%/day). Expression of TGF-α , β-FGF, and EGF receptors was unchanged. Eradication of HP results in reduction of gastric, but not duodenal,MPFS and has no effect on the growth factors measured. Increased MPFS associated with HP gastritis may relate to the potential for neoplastic transformation.
