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Gastric intestinal metaplasia is associated with gastric dysplasia but is inversely correlated with esophageal dysplasia 被引量:3
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作者 Justin M Gomez James T Patrie +6 位作者 wissam bleibel Jeanetta W Frye Bryan G Sauer Vanessa M Shami Edward B Stelow Christopher A Moskaluk Andrew Y Wang 《World Journal of Gastrointestinal Endoscopy》 CAS 2017年第2期61-69,共9页
AIMTo determine which clinical factors might be associated with gastric intestinal metaplasia (IM) in a North American population. METHODSPathology and endoscopy databases at an academic medical center were reviewed t... AIMTo determine which clinical factors might be associated with gastric intestinal metaplasia (IM) in a North American population. METHODSPathology and endoscopy databases at an academic medical center were reviewed to identify patients with and without gastric IM on biopsies for a retrospective cohort study. Patient demographics, insurance status, and other clinical factors were reviewed. RESULTSFour hundred and sixty-eight patients with gastric IM (mean age: 61.0 years ± 14.4 years, 55.5% female) and 171 without gastric IM (mean age: 48.8 years ± 20.8 years, 55.0% female) were compared. The endoscopic appearance of atrophic gastritis correlated with finding gastric IM on histopathology (OR = 2.05, P = 0.051). Gastric IM was associated with histologic findings of chronic gastritis (OR = 2.56, P P = 0.015), gastric dysplasia (OR = 6.11, P = 0.038), and gastric cancer (OR = 6.53, P = 0.027). Histologic findings of Barrett’s esophagus (OR = 0.28, P = 0.003) and esophageal dysplasia (OR = 0.11, P = 0.014) were inversely associated with gastric IM. Tobacco use (OR = 1.73, P = 0.005) was associated with gastric IM. CONCLUSIONPatients who smoke or have the endoscopic finding of atrophic gastritis are more likely to have gastric IM and should have screening gastric biopsies during esophagogastroduodenoscopy (EGD). Patients with gastric IM are at increased risk for having gastric dysplasia and cancer, and surveillance EGD with gastric biopsies in these patients might be reasonable. 展开更多
关键词 GASTRIC Intestinal metaplasia Atrophic gastritis BIOPSIES ESOPHAGOGASTRODUODENOSCOPY
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