Research on deep-tissue photothermal therapy(PTT)in the near-infrared II(NIR-II,1000–1350 nm)region has bloomed in recent years,owing to higher maximum permissible exposure and deeper tissue penetration over that in ...Research on deep-tissue photothermal therapy(PTT)in the near-infrared II(NIR-II,1000–1350 nm)region has bloomed in recent years,owing to higher maximum permissible exposure and deeper tissue penetration over that in the near-infrared I(NIR-I,650–950 nm)region.However,more details need to be uncovered to facilitate a fundamental understanding of NIR-ⅡPTT.Herein,a tumor-targeted therapeutic nanosystem based on NIR-responsive molybdenum oxide(MoO2)nanoaggregates was fabricated.The photothermal conversion capabilities of MoO2 in the NIR-I andⅡregions were investigated step by step,from a simple tissue phantom to a three-dimensional cellular system,and further to a tumor-bearing animal model.NIR-Ⅱlaser exhibited a lower photothermal attenuation coefficient(0.541 at1064 nm)in a tissue phantom compared with its counterpart(0.959 at 808 nm),which allows it to be more capable of deeptissue PTT in vitro and in vivo.Depth profile analysis elucidated a negative correlation between the microstructural collapse of tumor tissue and the penetration depth.Moreover,the depth-related tumor ablation was also studied by Raman fingerprint analysis,which demonstrated the major biochemical compositional disturbances in photothermal ablated tumor tissues,providing fundamental knowledge to NIR-Ⅱdeeptissue photothermal therapy.展开更多
基金This work was supported by the National Natural Science Foundation of China(11874021,61675072,81601534 and 51402207)the Science and Technology Project of Guangdong Province of China(2017A020215059)the Science and Technology Project of Guangzhou City(201904010323).
文摘Research on deep-tissue photothermal therapy(PTT)in the near-infrared II(NIR-II,1000–1350 nm)region has bloomed in recent years,owing to higher maximum permissible exposure and deeper tissue penetration over that in the near-infrared I(NIR-I,650–950 nm)region.However,more details need to be uncovered to facilitate a fundamental understanding of NIR-ⅡPTT.Herein,a tumor-targeted therapeutic nanosystem based on NIR-responsive molybdenum oxide(MoO2)nanoaggregates was fabricated.The photothermal conversion capabilities of MoO2 in the NIR-I andⅡregions were investigated step by step,from a simple tissue phantom to a three-dimensional cellular system,and further to a tumor-bearing animal model.NIR-Ⅱlaser exhibited a lower photothermal attenuation coefficient(0.541 at1064 nm)in a tissue phantom compared with its counterpart(0.959 at 808 nm),which allows it to be more capable of deeptissue PTT in vitro and in vivo.Depth profile analysis elucidated a negative correlation between the microstructural collapse of tumor tissue and the penetration depth.Moreover,the depth-related tumor ablation was also studied by Raman fingerprint analysis,which demonstrated the major biochemical compositional disturbances in photothermal ablated tumor tissues,providing fundamental knowledge to NIR-Ⅱdeeptissue photothermal therapy.
