Increasing evidence indicates that microRNAs(miRNAs),endogenous short non-coding RNAs 19–24 nucleotides in length,play key regulatory roles in various biological events at the post-transcriptional level.Embryonic ste...Increasing evidence indicates that microRNAs(miRNAs),endogenous short non-coding RNAs 19–24 nucleotides in length,play key regulatory roles in various biological events at the post-transcriptional level.Embryonic stem cells(ESCs)represent a valuable tool for disease modeling,drug discovery,developmental studies,and potential cell-based therapies in regenerative medicine due to their unlimited self-renewal and pluripotency.Therefore,remarkable progress has been made in recent decades toward understanding the expression and functions of specific miRNAs in the establishment and maintenance of pluripotency.Here,we summarize the recent knowledge regarding the regulatory roles of miRNAs in self-renewal of pluripotent ESCs and during cellular reprogramming,as well as the potential role of miRNAs in two distinct pluripotent states(naïve and primed).展开更多
基金This work was supported by a grant from the Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education,Science,and Technology。
文摘Increasing evidence indicates that microRNAs(miRNAs),endogenous short non-coding RNAs 19–24 nucleotides in length,play key regulatory roles in various biological events at the post-transcriptional level.Embryonic stem cells(ESCs)represent a valuable tool for disease modeling,drug discovery,developmental studies,and potential cell-based therapies in regenerative medicine due to their unlimited self-renewal and pluripotency.Therefore,remarkable progress has been made in recent decades toward understanding the expression and functions of specific miRNAs in the establishment and maintenance of pluripotency.Here,we summarize the recent knowledge regarding the regulatory roles of miRNAs in self-renewal of pluripotent ESCs and during cellular reprogramming,as well as the potential role of miRNAs in two distinct pluripotent states(naïve and primed).
