Objective:To study the epidemiological features of pancreatic cystadenoma and cystadenocarcinoma in China during the last 10 years and to analyze the diagnosis and treatment.Methods:Reports on pancreatic cystadenoma a...Objective:To study the epidemiological features of pancreatic cystadenoma and cystadenocarcinoma in China during the last 10 years and to analyze the diagnosis and treatment.Methods:Reports on pancreatic cystadenoma and cystadenocarcinoma published from 2000 to 2009 were retrieved from various databases,such as WANFANG data,VIP web and China National Knowledge Infrastructure(CNKI).The epidemiological features of pancreatic cystadenoma and cystadenocarcinoma and its diagnosis and treatment were analyzed.Results:Totally 1 865 patients with pancreatic cystadenoma and cystadenocarcinoma were reported in China during the last 10 years.The male to female ratio was approximately 1:2.1.The accurate ages were reported in 1 536 cases,the average age of them was 50.8 years,whose average age from 40 to 60 years old accounted 75.9% of the patients.65.3% of the cases were located in East China and Central China.Abdominal pain was the main clinical manifestation and was found in 54.9% of the patients.Pancreatoduodenectomy and resection of body and tail of the pancreas were the main procedure for the treatment of pancreatic cystadenoma and cystadenocarcinoma.Conclusion:Pancreatic cystadenoma and cystadenocarcinoma were mainly found in older women in East and Central China.Preoperative diagnosis is difficult.Pancreatoduodenectomy and resection of pancreatic body and tail were the main procedure for the treatment of pancreatic cystadenoma and cystadenocarcinoma.展开更多
目的探讨原发性阑尾肿瘤患者手术后影响生存的独立危险因素,构建并验证列线图,帮助识别高危患者,制定个体化治疗方案。方法回顾性收集美国Surveillance,Epidemiology,and End Results(SEER)数据库2010~2015年诊断为阑尾肿瘤的患者临床资...目的探讨原发性阑尾肿瘤患者手术后影响生存的独立危险因素,构建并验证列线图,帮助识别高危患者,制定个体化治疗方案。方法回顾性收集美国Surveillance,Epidemiology,and End Results(SEER)数据库2010~2015年诊断为阑尾肿瘤的患者临床资料,随机分为训练队列和验证队列。采用多因素Cox回归分析影响原发性阑尾肿瘤术后患者总生存期(OS)的独立危险因素,开发了一种新的列线图模型,并通过内部验证进行评估。结果年龄、病理分型、肿瘤分化、N分期、M分期、淋巴结清扫数量、CEA状态是影响术后阑尾肿瘤患者预后的独立危险因素(P<0.05)。该列线图训练队列的C指数为0.811(95%CI:0.797~0.825),验证队列的C指数为0.844(95%CI:0.819~0.869)。1、3、5年总生存率ROC曲线下面积(AUC)在训练队列和验证队列中分别为0.807、0.849、0.824和0.857、0.862、0.825。采用X年10次200折交叉验证,进一步验证预测模型区分不同结局事件患者的能力。校准曲线和临床决策曲线(DCA)显示具有良好的一致性和临床获益。风险分级系统将所有患者分为三组,Kaplan-Meier曲线显示不同组间OS具有良好的分层和区分能力。结论我们开发了一种新的列线图模型来预测原发性阑尾肿瘤术后OS。此外,风险分级系统有助于准确评估预后和指导治疗。展开更多
文摘Objective:To study the epidemiological features of pancreatic cystadenoma and cystadenocarcinoma in China during the last 10 years and to analyze the diagnosis and treatment.Methods:Reports on pancreatic cystadenoma and cystadenocarcinoma published from 2000 to 2009 were retrieved from various databases,such as WANFANG data,VIP web and China National Knowledge Infrastructure(CNKI).The epidemiological features of pancreatic cystadenoma and cystadenocarcinoma and its diagnosis and treatment were analyzed.Results:Totally 1 865 patients with pancreatic cystadenoma and cystadenocarcinoma were reported in China during the last 10 years.The male to female ratio was approximately 1:2.1.The accurate ages were reported in 1 536 cases,the average age of them was 50.8 years,whose average age from 40 to 60 years old accounted 75.9% of the patients.65.3% of the cases were located in East China and Central China.Abdominal pain was the main clinical manifestation and was found in 54.9% of the patients.Pancreatoduodenectomy and resection of body and tail of the pancreas were the main procedure for the treatment of pancreatic cystadenoma and cystadenocarcinoma.Conclusion:Pancreatic cystadenoma and cystadenocarcinoma were mainly found in older women in East and Central China.Preoperative diagnosis is difficult.Pancreatoduodenectomy and resection of pancreatic body and tail were the main procedure for the treatment of pancreatic cystadenoma and cystadenocarcinoma.
文摘目的探讨原发性阑尾肿瘤患者手术后影响生存的独立危险因素,构建并验证列线图,帮助识别高危患者,制定个体化治疗方案。方法回顾性收集美国Surveillance,Epidemiology,and End Results(SEER)数据库2010~2015年诊断为阑尾肿瘤的患者临床资料,随机分为训练队列和验证队列。采用多因素Cox回归分析影响原发性阑尾肿瘤术后患者总生存期(OS)的独立危险因素,开发了一种新的列线图模型,并通过内部验证进行评估。结果年龄、病理分型、肿瘤分化、N分期、M分期、淋巴结清扫数量、CEA状态是影响术后阑尾肿瘤患者预后的独立危险因素(P<0.05)。该列线图训练队列的C指数为0.811(95%CI:0.797~0.825),验证队列的C指数为0.844(95%CI:0.819~0.869)。1、3、5年总生存率ROC曲线下面积(AUC)在训练队列和验证队列中分别为0.807、0.849、0.824和0.857、0.862、0.825。采用X年10次200折交叉验证,进一步验证预测模型区分不同结局事件患者的能力。校准曲线和临床决策曲线(DCA)显示具有良好的一致性和临床获益。风险分级系统将所有患者分为三组,Kaplan-Meier曲线显示不同组间OS具有良好的分层和区分能力。结论我们开发了一种新的列线图模型来预测原发性阑尾肿瘤术后OS。此外,风险分级系统有助于准确评估预后和指导治疗。
