目的分析基于前馈控制(FFC)理论的护理干预在胸腔镜肺叶切除术(TL)患者静脉自控镇痛(PCIA)中的应用效果。方法将100例TL患者以随机数字表法分为观察组和对照组,各50例。对照组患者给予PCIA及常规护理干预,观察组患者在对照组基础上给予...目的分析基于前馈控制(FFC)理论的护理干预在胸腔镜肺叶切除术(TL)患者静脉自控镇痛(PCIA)中的应用效果。方法将100例TL患者以随机数字表法分为观察组和对照组,各50例。对照组患者给予PCIA及常规护理干预,观察组患者在对照组基础上给予基于FFC理论的护理干预,比较两组患者术后不同时间段视觉模拟评分量表(VAS)评分、Bruggermann舒适(BCS)评分、术后机体转归指标、术后24 h PCIA按压次数、患者满意度。结果术后24 h观察组患者VAS评分低于对照组,BCS评分高于对照组(P<0.01)。干预后,观察组患者拔除尿管时间、首次排气时间、首次下床时间均早于对照组,术后24 h PCIA按压次数少于对照组,满意度高于对照组(P<0.01)。结论基于FFC理论的护理干预可有效减轻TL患者术后疼痛感,缩短胃肠功能恢复时间,提高患者舒适度及满意度。展开更多
Objective:To study the protective mechanism of Yizhiren on the diabetic nephropathy(DN)mouse model based on network pharmacology and metabolomics.Methods:Urea nitrogen,urinary creatinine,urinary albumin were detected ...Objective:To study the protective mechanism of Yizhiren on the diabetic nephropathy(DN)mouse model based on network pharmacology and metabolomics.Methods:Urea nitrogen,urinary creatinine,urinary albumin were detected in each group of mice,and pathological sections of mice kidney were observed.TCMSP database was used to search for the components and targets of Yizhiren,GeneCards database was used to search for DN-related genes,and drug-component-target-disease network and KEGG signaling pathway were constructed.The fecal samples of mice in the Yizhiren group and the Saline group were collected,metabolomics techniques were used to screen different metabolites,and potential metabolic pathways were analyzed using KEGG database.Results:Compared with the model group,Yizhiren significantly reduced the levels of urea nitrogen,urinary creatinine and urinary albumin in DN mice(P<0.05 or P<0.01),and improved the renal pathology of mice.It was predicted that Yizhiren had 4 effective components and 28 potential targets for treating DN.The KEGG enriched 43 signal pathways,and the main metabolic pathway was lipid metabolism.A total of 584 different metabolites were screened from feces of the two groups(P<0.05).The main metabolic pathways were lipid metabolism,namely sphingolipid metabolism and glycerol phospholipid metabolism,among which the metabolites contained mainly sphingolipin,phosphatidylcholine,lysophosphatidylcholine and phosphatidylethanolamine.Compared with the normal saline group,these four metabolites in Yizhiren decreased significantly(P<0.01 or P<0.001).Conclusion:The protective mechanism of Yizhiren in DN mice may be related to the regulation of sphingolipid metabolism,glycerol phospholipid metabolism and the disorder of its metabolites.展开更多
文摘目的分析基于前馈控制(FFC)理论的护理干预在胸腔镜肺叶切除术(TL)患者静脉自控镇痛(PCIA)中的应用效果。方法将100例TL患者以随机数字表法分为观察组和对照组,各50例。对照组患者给予PCIA及常规护理干预,观察组患者在对照组基础上给予基于FFC理论的护理干预,比较两组患者术后不同时间段视觉模拟评分量表(VAS)评分、Bruggermann舒适(BCS)评分、术后机体转归指标、术后24 h PCIA按压次数、患者满意度。结果术后24 h观察组患者VAS评分低于对照组,BCS评分高于对照组(P<0.01)。干预后,观察组患者拔除尿管时间、首次排气时间、首次下床时间均早于对照组,术后24 h PCIA按压次数少于对照组,满意度高于对照组(P<0.01)。结论基于FFC理论的护理干预可有效减轻TL患者术后疼痛感,缩短胃肠功能恢复时间,提高患者舒适度及满意度。
基金This study was supported by National Natural Science Foundation of China(No.82174334)Natural Science Foundation of Hainan Province(No.821QN417)。
文摘Objective:To study the protective mechanism of Yizhiren on the diabetic nephropathy(DN)mouse model based on network pharmacology and metabolomics.Methods:Urea nitrogen,urinary creatinine,urinary albumin were detected in each group of mice,and pathological sections of mice kidney were observed.TCMSP database was used to search for the components and targets of Yizhiren,GeneCards database was used to search for DN-related genes,and drug-component-target-disease network and KEGG signaling pathway were constructed.The fecal samples of mice in the Yizhiren group and the Saline group were collected,metabolomics techniques were used to screen different metabolites,and potential metabolic pathways were analyzed using KEGG database.Results:Compared with the model group,Yizhiren significantly reduced the levels of urea nitrogen,urinary creatinine and urinary albumin in DN mice(P<0.05 or P<0.01),and improved the renal pathology of mice.It was predicted that Yizhiren had 4 effective components and 28 potential targets for treating DN.The KEGG enriched 43 signal pathways,and the main metabolic pathway was lipid metabolism.A total of 584 different metabolites were screened from feces of the two groups(P<0.05).The main metabolic pathways were lipid metabolism,namely sphingolipid metabolism and glycerol phospholipid metabolism,among which the metabolites contained mainly sphingolipin,phosphatidylcholine,lysophosphatidylcholine and phosphatidylethanolamine.Compared with the normal saline group,these four metabolites in Yizhiren decreased significantly(P<0.01 or P<0.001).Conclusion:The protective mechanism of Yizhiren in DN mice may be related to the regulation of sphingolipid metabolism,glycerol phospholipid metabolism and the disorder of its metabolites.
