During the development of human fetus,all organs consisting of various types of cells are in rapid growth.The significance of these cells and the chemical components involved,especially those of special functions in m...During the development of human fetus,all organs consisting of various types of cells are in rapid growth.The significance of these cells and the chemical components involved,especially those of special functions in medical treatment of certain refractory diseases,have been noticed gradually.The questions as a step further are therefore raised,e.g.what is the mechanism underlying the clinical effectiveness and how to produce the active substances in large amount by biological engineering technique or chemical synthetic method,instead of using the crude preparation directly derived from fetus.展开更多
By means of comet assay, a study of kinetics curve of DNA damage repair in irradiated SX-9 cells that came from mouse breast cancer proceeded. It was found that while the initial DNA damages had nearly been repaired, ...By means of comet assay, a study of kinetics curve of DNA damage repair in irradiated SX-9 cells that came from mouse breast cancer proceeded. It was found that while the initial DNA damages had nearly been repaired, DNA damages arose for the second time, then they were repaired again. As a result, a phenomenon of "secondary damage" was found during the repair of DNA damages in irradiated SX-9 cells. Further research illuminated that 3-aminobenzamide (3AB), which is an inhibitor of poly (ADP-ribose) polymerase, could change the proceeding of "secondary damage". For this reason it is possible that there exists some inner relationship between the phenomenon of "secondary damage" and the function of poly(ADP-ribose) polymerase.展开更多
文摘During the development of human fetus,all organs consisting of various types of cells are in rapid growth.The significance of these cells and the chemical components involved,especially those of special functions in medical treatment of certain refractory diseases,have been noticed gradually.The questions as a step further are therefore raised,e.g.what is the mechanism underlying the clinical effectiveness and how to produce the active substances in large amount by biological engineering technique or chemical synthetic method,instead of using the crude preparation directly derived from fetus.
文摘By means of comet assay, a study of kinetics curve of DNA damage repair in irradiated SX-9 cells that came from mouse breast cancer proceeded. It was found that while the initial DNA damages had nearly been repaired, DNA damages arose for the second time, then they were repaired again. As a result, a phenomenon of "secondary damage" was found during the repair of DNA damages in irradiated SX-9 cells. Further research illuminated that 3-aminobenzamide (3AB), which is an inhibitor of poly (ADP-ribose) polymerase, could change the proceeding of "secondary damage". For this reason it is possible that there exists some inner relationship between the phenomenon of "secondary damage" and the function of poly(ADP-ribose) polymerase.
