Background and goal: Several known coronavirus species cause a variety of dise ases, including respiratory or enteric diseases. The purpose of this study was to investigate the interesting enteric symptoms of the medi...Background and goal: Several known coronavirus species cause a variety of dise ases, including respiratory or enteric diseases. The purpose of this study was to investigate the interesting enteric symptoms of the medical care workers who were evidently infected with SARS by means of respiratory transmission. Study: Between May 1 and June 16, 2003, we enrolled 16 medical care workers who fulfilled the definition of probable SARS. Samples used for the detection of coronavirus RNA by RT-PCR were collected from throat and rectal swabs during acute phase. S erum anti SARS IgG was checked by enzyme linked immunosorbent assays at the co nvalescent phase. Results: The incidence of watery diarrhea was 18.8%(3 of 16). The RT PCR of coronavirus was positive in three (18.8%) of 16 throat swabs an d in none (0%) of seven rectal swabs. Serum anti coronavirus IgG was positive in 13 of the 15 patients (86.7%). The mortality rate was 6.25%(1 of 16). The d iarrhea rate in our hospital was significantly lower in comparison with the 73% (55 of 75) of the Amoy Gardens outbreak in Hong Kong (P = 0.000073), and similar to the 19.6%(27 of 138) of the hospital acquired outbreak in the Prince of Wa les Hospital in Hong Kong (P= 0.798). In contrast to the high positive rate of f eces RT-PCR (97%)in Amoy Gardens, our positive rate in rectal swab RT PCT (0 %) was significantly lower (P = 0.00000002). Conclusions: Hospital acquired SA RS cases infected mainly by respiratory route less commonly presented with diarr hea. Lower intestinal viral load, when the virus spread by respiratory route, may be contributive to lower diarrhea rate and lower positive rate in rectal swab RT-PCR.展开更多
文摘Background and goal: Several known coronavirus species cause a variety of dise ases, including respiratory or enteric diseases. The purpose of this study was to investigate the interesting enteric symptoms of the medical care workers who were evidently infected with SARS by means of respiratory transmission. Study: Between May 1 and June 16, 2003, we enrolled 16 medical care workers who fulfilled the definition of probable SARS. Samples used for the detection of coronavirus RNA by RT-PCR were collected from throat and rectal swabs during acute phase. S erum anti SARS IgG was checked by enzyme linked immunosorbent assays at the co nvalescent phase. Results: The incidence of watery diarrhea was 18.8%(3 of 16). The RT PCR of coronavirus was positive in three (18.8%) of 16 throat swabs an d in none (0%) of seven rectal swabs. Serum anti coronavirus IgG was positive in 13 of the 15 patients (86.7%). The mortality rate was 6.25%(1 of 16). The d iarrhea rate in our hospital was significantly lower in comparison with the 73% (55 of 75) of the Amoy Gardens outbreak in Hong Kong (P = 0.000073), and similar to the 19.6%(27 of 138) of the hospital acquired outbreak in the Prince of Wa les Hospital in Hong Kong (P= 0.798). In contrast to the high positive rate of f eces RT-PCR (97%)in Amoy Gardens, our positive rate in rectal swab RT PCT (0 %) was significantly lower (P = 0.00000002). Conclusions: Hospital acquired SA RS cases infected mainly by respiratory route less commonly presented with diarr hea. Lower intestinal viral load, when the virus spread by respiratory route, may be contributive to lower diarrhea rate and lower positive rate in rectal swab RT-PCR.
